probenecid-2464 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the probenecid-2464 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADCK2 aarF domain containing kinase 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKR1C4 aldo-keto reductase family 1, member C4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP1 aquaporin 1 (Colton blood group)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASIC4 acid sensing (proton gated) ion channel family member 4
BMP1 bone morphogenetic protein 1
CA12 carbonic anhydrase XII
CCDC92 coiled-coil domain containing 92
CCSER2 coiled-coil serine-rich protein 2
CD1E CD1e molecule
CDKL3 cyclin-dependent kinase-like 3
CHI3L2 chitinase 3-like 2
COL10A1 collagen, type X, alpha 1
CREM cAMP responsive element modulator
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSZ cathepsin Z
DNAI2 dynein, axonemal, intermediate chain 2
EFR3B EFR3 homolog B (S. cerevisiae)
EML2 echinoderm microtubule associated protein like 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESM1 endothelial cell-specific molecule 1
FAM182B family with sequence similarity 182, member B
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GATA3 GATA binding protein 3
GJA8 gap junction protein, alpha 8, 50kDa
GPC1 glypican 1
GPR176 G protein-coupled receptor 176
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GSPT1 G1 to S phase transition 1
GYPB glycophorin B (MNS blood group)
HIST1H2AI histone cluster 1, H2ai
HIST1H2BG histone cluster 1, H2bg
HOXA10 homeobox A10
HPX hemopexin
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KIF1C kinesin family member 1C
KLF3 Kruppel-like factor 3 (basic)
KLHL36 kelch-like family member 36
KLK13 kallikrein-related peptidase 13
LAMP3 lysosomal-associated membrane protein 3
LEFTY1 left-right determination factor 1
LOC257152 uncharacterized LOC257152
LOC390998 ribosomal protein L10 pseudogene
LOC647070 uncharacterized LOC647070
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEB4 melanoma antigen family B4
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MED16 mediator complex subunit 16
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MPDZ multiple PDZ domain protein
MRPL44 mitochondrial ribosomal protein L44
MTCP1 mature T-cell proliferation 1
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OLAH oleoyl-ACP hydrolase
OMG oligodendrocyte myelin glycoprotein
OXCT2 3-oxoacid CoA transferase 2
PAX5 paired box 5
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLSCR3 phospholipid scramblase 3
PODNL1 podocan-like 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRB1 proline-rich protein BstNI subfamily 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RAB11B RAB11B, member RAS oncogene family
RANBP1 RAN binding protein 1
RELN reelin
RFPL2 ret finger protein-like 2
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SOCS2 suppressor of cytokine signaling 2
SPDEF SAM pointed domain containing ETS transcription factor
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TACC1 transforming, acidic coiled-coil containing protein 1
TAS2R1 taste receptor, type 2, member 1
TEF thyrotrophic embryonic factor
TLDC1 TBC/LysM-associated domain containing 1
TLN2 talin 2
TMPRSS15 transmembrane protease, serine 15
TNK1 tyrosine kinase, non-receptor, 1
TRAF4 TNF receptor-associated factor 4
TRBC1 T cell receptor beta constant 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
YLPM1 YLP motif containing 1
ZER1 zyg-11 related, cell cycle regulator
ZNF280A zinc finger protein 280A
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ADGRE1 adhesion G protein-coupled receptor E1
ALS2CL ALS2 C-terminal like
ARL15 ADP-ribosylation factor-like 15
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
ATXN2L ataxin 2-like
BANK1 B-cell scaffold protein with ankyrin repeats 1
C16ORF59 chromosome 16 open reading frame 59
C21ORF91 chromosome 21 open reading frame 91
CARF calcium responsive transcription factor
CD1D CD1d molecule
CENPJ centromere protein J
CLCN2 chloride channel, voltage-sensitive 2
CNTN1 contactin 1
CRY2 cryptochrome circadian clock 2
CXCR2 chemokine (C-X-C motif) receptor 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPTOR DEP domain containing MTOR-interacting protein
DGKG diacylglycerol kinase, gamma 90kDa
DSE dermatan sulfate epimerase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F13A1 coagulation factor XIII, A1 polypeptide
FBXO31 F-box protein 31
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXD1 forkhead box D1
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GTF2I general transcription factor IIi
HIST1H2AC histone cluster 1, H2ac
HMGB3P1 high mobility group box 3 pseudogene 1
HRH2 histamine receptor H2
INCENP inner centromere protein antigens 135/155kDa
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCTD20 potassium channel tetramerization domain containing 20
KLHL28 kelch-like family member 28
KLK5 kallikrein-related peptidase 5
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LNPEP leucyl/cystinyl aminopeptidase
LOC100287590 uncharacterized LOC100287590
LY6G6C lymphocyte antigen 6 complex, locus G6C
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MIR22HG MIR22 host gene
MLPH melanophilin
MTRF1 mitochondrial translational release factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCALD neurocalcin delta
NCS1 neuronal calcium sensor 1
NLK nemo-like kinase
NSUN6 NOP2/Sun domain family, member 6
NT5DC3 5'-nucleotidase domain containing 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
POM121L2 POM121 transmembrane nucleoporin-like 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP2 RAP1 GTPase activating protein 2
REC8 REC8 meiotic recombination protein
RFPL1S RFPL1 antisense RNA 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RPL10L ribosomal protein L10-like
SALL2 spalt-like transcription factor 2
SCAMP5 secretory carrier membrane protein 5
SCRN3 secernin 3
SCUBE3 signal peptide, CUB domain, EGF-like 3
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC15 sialic acid binding Ig-like lectin 15
SIL1 SIL1 nucleotide exchange factor
SLC22A14 solute carrier family 22, member 14
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLFN12 schlafen family member 12
SNIP1 Smad nuclear interacting protein 1
SNX29P2 sorting nexin 29 pseudogene 2
TBC1D19 TBC1 domain family, member 19
THEM6 thioesterase superfamily member 6
TMEM209 transmembrane protein 209
TMEM246 transmembrane protein 246
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM25 tripartite motif containing 25
UNC119 unc-119 homolog (C. elegans)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VEGFB vascular endothelial growth factor B
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
ZDHHC13 zinc finger, DHHC-type containing 13
ZFAND3 zinc finger, AN1-type domain 3
ZNF215 zinc finger protein 215
ZNF574 zinc finger protein 574
ZNF862 zinc finger protein 862