proadifen-7165 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the proadifen-7165 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP11A ATPase, class VI, type 11A
BAIAP2 BAI1-associated protein 2
C2ORF54 chromosome 2 open reading frame 54
C8A complement component 8, alpha polypeptide
CAMK1 calcium/calmodulin-dependent protein kinase I
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC25C cell division cycle 25C
CDHR2 cadherin-related family member 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CUL2 cullin 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DLC1 DLC1 Rho GTPase activating protein
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DOHH deoxyhypusine hydroxylase/monooxygenase
DOK4 docking protein 4
DST dystonin
DUSP1 dual specificity phosphatase 1
DXO decapping exoribonuclease
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
ELL2 elongation factor, RNA polymerase II, 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GHRHR growth hormone releasing hormone receptor
GMEB1 glucocorticoid modulatory element binding protein 1
GSTM4 glutathione S-transferase mu 4
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HLA-DMB major histocompatibility complex, class II, DM beta
HPN hepsin
HRH2 histamine receptor H2
HRK harakiri, BCL2 interacting protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RN interleukin 1 receptor antagonist
INHBE inhibin, beta E
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLF10 Kruppel-like factor 10
LYST lysosomal trafficking regulator
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED14 mediator complex subunit 14
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NRSN2 neurensin 2
OASL 2'-5'-oligoadenylate synthetase-like
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
QPCT glutaminyl-peptide cyclotransferase
RAB36 RAB36, member RAS oncogene family
RAD51 RAD51 recombinase
RAPSN receptor-associated protein of the synapse
RARG retinoic acid receptor, gamma
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIN2 Ras and Rab interactor 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCAI suppressor of cancer cell invasion
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SP100 SP100 nuclear antigen
SSPN sarcospan
STRN striatin, calmodulin binding protein
TBC1D2 TBC1 domain family, member 2
TEP1 telomerase-associated protein 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TTC12 tetratricopeptide repeat domain 12
VARS valyl-tRNA synthetase
VEGFA vascular endothelial growth factor A
VPRBP Vpr (HIV-1) binding protein
XYLB xylulokinase homolog (H. influenzae)
ZC3H7B zinc finger CCCH-type containing 7B
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF329 zinc finger protein 329
ZNF609 zinc finger protein 609
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARRB2 arrestin, beta 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
AXIN1 axin 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAHD1 bromo adjacent homology domain containing 1
C11ORF80 chromosome 11 open reading frame 80
C12ORF43 chromosome 12 open reading frame 43
C16ORF59 chromosome 16 open reading frame 59
C2CD2 C2 calcium-dependent domain containing 2
CAPN15 calpain 15
CBX4 chromobox homolog 4
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CHMP6 charged multivesicular body protein 6
CHPF chondroitin polymerizing factor
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSPN claspin
COCH cochlin
CTSK cathepsin K
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSPP dentin sialophosphoprotein
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM111A family with sequence similarity 111, member A
FBXW12 F-box and WD repeat domain containing 12
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FZD4 frizzled class receptor 4
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOOK1 hook microtubule-tethering protein 1
IL4R interleukin 4 receptor
IPO8 importin 8
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA0125 KIAA0125
KIAA0556 KIAA0556
KRT13 keratin 13, type I
LMNB1 lamin B1
LRRC49 leucine rich repeat containing 49
MAP9 microtubule-associated protein 9
MAPK12 mitogen-activated protein kinase 12
MUM1 melanoma associated antigen (mutated) 1
OPN3 opsin 3
PCDHB3 protocadherin beta 3
PGM1 phosphoglucomutase 1
PHACTR4 phosphatase and actin regulator 4
PLAC8 placenta-specific 8
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POR P450 (cytochrome) oxidoreductase
POTEKP POTE ankyrin domain family, member K, pseudogene
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR7 proline rich 7 (synaptic)
PSKH1 protein serine kinase H1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBM15B RNA binding motif protein 15B
RCOR3 REST corepressor 3
RNF31 ring finger protein 31
RPAP2 RNA polymerase II associated protein 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAMHD1 SAM domain and HD domain 1
SCD5 stearoyl-CoA desaturase 5
SETD6 SET domain containing 6
SETMAR SET domain and mariner transposase fusion gene
SH2B3 SH2B adaptor protein 3
SH3BGR SH3 domain binding glutamate-rich protein
SKA1 spindle and kinetochore associated complex subunit 1
SNHG3 small nucleolar RNA host gene 3
SOX12 SRY (sex determining region Y)-box 12
TBX19 T-box 19
TCTA T-cell leukemia translocation altered
TET3 tet methylcytosine dioxygenase 3
TLN1 talin 1
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNS2 tensin 2
TPST2 tyrosylprotein sulfotransferase 2
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC30A tetratricopeptide repeat domain 30A
VAV1 vav 1 guanine nucleotide exchange factor
WDR19 WD repeat domain 19
WDR4 WD repeat domain 4
WDR60 WD repeat domain 60
YBX2 Y box binding protein 2
ZBED8 zinc finger, BED-type containing 8
ZBTB48 zinc finger and BTB domain containing 48
ZNF180 zinc finger protein 180
ZNF254 zinc finger protein 254
ZNF768 zinc finger protein 768