primary open angle glaucoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_1070)
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Genes

319 genes co-occuring with the disease primary open angle glaucoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.17325
OPTN optineurin 2.44601
WDR36 WD repeat domain 36 2.23513
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.75233
LOXL1 lysyl oxidase-like 1 1.60413
SRBD1 S1 RNA binding domain 1 1.57156
TMCO1 transmembrane and coiled-coil domains 1 1.51457
TGFB2 transforming growth factor, beta 2 1.47638
ASB10 ankyrin repeat and SOCS box containing 10 1.38166
TMTC2 transmembrane and tetratricopeptide repeat containing 2 1.38036
CAV2 caveolin 2 1.35333
SIX6 SIX homeobox 6 1.31319
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.28566
SIX1 SIX homeobox 1 1.23212
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 1.22345
CAV1 caveolin 1, caveolae protein, 22kDa 1.12361
ATOH7 atonal homolog 7 (Drosophila) 1.10552
RFTN1 raftlin, lipid raft linker 1 1.10216
FN1 fibronectin 1 1.10175
PCOLCE2 procollagen C-endopeptidase enhancer 2 1.10132
CTGF connective tissue growth factor 1.09209
PTGDR prostaglandin D2 receptor (DP) 1.08747
GAS7 growth arrest-specific 7 1.07278
LTBP3 latent transforming growth factor beta binding protein 3 1.0383
NTF4 neurotrophin 4 1.03325
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 1.0244
ZP4 zona pellucida glycoprotein 4 1.01385
ELOVL5 ELOVL fatty acid elongase 5 0.999503
LTBP2 latent transforming growth factor beta binding protein 2 0.997392
PDIA5 protein disulfide isomerase family A, member 5 0.989379
PLXDC2 plexin domain containing 2 0.984321
C1ORF27 chromosome 1 open reading frame 27 0.975062
COCH cochlin 0.96918
OPTC opticin 0.964986
PEX19 peroxisomal biogenesis factor 19 0.960797
C12ORF56 chromosome 12 open reading frame 56 0.956196
HEYL hes-related family bHLH transcription factor with YRPW motif-like 0.947435
OLFM2 olfactomedin 2 0.946603
MVB12B multivesicular body subunit 12B 0.944938
TMEM182 transmembrane protein 182 0.944938
GSTM1 glutathione S-transferase mu 1 0.942858
ZNF343 zinc finger protein 343 0.939119
NBPF12 neuroblastoma breakpoint family, member 12 0.923387
AFAP1 actin filament associated protein 1 0.892538
ZNF469 zinc finger protein 469 0.888848
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.88516
DTWD2 DTW domain containing 2 0.882292
PSD4 pleckstrin and Sec7 domain containing 4 0.882292
OLFM1 olfactomedin 1 0.873281
GSTTP1 glutathione S-transferase theta pseudogene 1 0.865912
GSTT1 glutathione S-transferase theta 1 0.865502
SYBU syntabulin (syntaxin-interacting) 0.865093
CPNE1 copine I 0.865093
UFSP2 UFM1-specific peptidase 2 0.865093
EDN1 endothelin 1 0.863046
OPA1 optic atrophy 1 (autosomal dominant) 0.86059
TIMP2 TIMP metallopeptidase inhibitor 2 0.859362
NCK2 NCK adaptor protein 2 0.856497
MMP2 matrix metallopeptidase 2 0.855677
FNDC3B fibronectin type III domain containing 3B 0.850764
BIRC6 baculoviral IAP repeat containing 6 0.850354
VAMP5 vesicle-associated membrane protein 5 0.842982
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.833148
BMP7 bone morphogenetic protein 7 0.813462
RAB8A RAB8A, member RAS oncogene family 0.80977
DMXL1 Dmx-like 1 0.798692
TGFB1 transforming growth factor, beta 1 0.775341
FBN1 fibrillin 1 0.766351
THBS1 thrombospondin 1 0.754527
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 0.74761
SOX30 SRY (sex determining region Y)-box 30 0.745172
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.735433
CRYBB1 crystallin, beta B1 0.726524
CNTNAP4 contactin associated protein-like 4 0.707559
HRAS Harvey rat sarcoma viral oncogene homolog 0.705949
COL5A1 collagen, type V, alpha 1 0.700722
TBKBP1 TBK1 binding protein 1 0.697911
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.694301
LMX1B LIM homeobox transcription factor 1, beta 0.693499
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.690293
HYAL3 hyaluronoglucosaminidase 3 0.677105
PER2 period circadian clock 2 0.666755
RND2 Rho family GTPase 2 0.665166
ADAMTSL3 ADAMTS-like 3 0.664769
TIMP1 TIMP metallopeptidase inhibitor 1 0.664372
MMP1 matrix metallopeptidase 1 0.65763
GTF3A general transcription factor IIIA 0.637889
ADGRL2 adhesion G protein-coupled receptor L2 0.627672
CTNNBL1 catenin, beta like 1 0.626103
FOXC1 forkhead box C1 0.625711
BTBD3 BTB (POZ) domain containing 3 0.624143
STIP1 stress-induced phosphoprotein 1 0.617486
TANK TRAF family member-associated NFKB activator 0.616312
VAV2 vav 2 guanine nucleotide exchange factor 0.603811
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.6003
TBK1 TANK-binding kinase 1 0.590169
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.589001
XPOT exportin, tRNA 0.580828
APOE apolipoprotein E 0.58005
TULP3 tubby like protein 3 0.574994
C7 complement component 7 0.571107
ANGPTL7 angiopoietin-like 7 0.571107
IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) 0.567609
MXD3 MAX dimerization protein 3 0.561392
COL8A2 collagen, type VIII, alpha 2 0.558285
PADI2 peptidyl arginine deiminase, type II 0.556344
NOS3 nitric oxide synthase 3 (endothelial cell) 0.552851
PEX5 peroxisomal biogenesis factor 5 0.549747
OLFM3 olfactomedin 3 0.549747
PRR4 proline rich 4 (lacrimal) 0.548971
SEC14L2 SEC14-like 2 (S. cerevisiae) 0.548195
RPN2 ribophorin II 0.547032
CD44 CD44 molecule (Indian blood group) 0.545868
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.544705
VAV3 vav 3 guanine nucleotide exchange factor 0.543155
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.540055
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.535409
AGTR2 angiotensin II receptor, type 2 0.52343
COL15A1 collagen, type XV, alpha 1 0.51919
SOD2 superoxide dismutase 2, mitochondrial 0.513802
GDF11 growth differentiation factor 11 0.502292
CD80 CD80 molecule 0.500761
CHSY1 chondroitin sulfate synthase 1 0.493885
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.493885
BMP4 bone morphogenetic protein 4 0.493122
VCAN versican 0.491215
GLCCI1 glucocorticoid induced 1 0.487027
MMP3 matrix metallopeptidase 3 0.486646
PLCB4 phospholipase C, beta 4 0.483985
NCOA2 nuclear receptor coactivator 2 0.482084
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.481325
IL15RA interleukin 15 receptor, alpha 0.477151
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.474498
FBLN1 fibulin 1 0.452585
GSTA4 glutathione S-transferase alpha 4 0.451454
NARF nuclear prelamin A recognition factor 0.448817
SCN4B sodium channel, voltage gated, type IV beta subunit 0.448064
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.445429
CARD10 caspase recruitment domain family, member 10 0.445429
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.443923
FHOD1 formin homology 2 domain containing 1 0.443547
MMP9 matrix metallopeptidase 9 0.441666
CDK14 cyclin-dependent kinase 14 0.438658
PITX2 paired-like homeodomain 2 0.43753
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.435275
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.434524
LUM lumican 0.434148
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.432646
ADGRL3 adhesion G protein-coupled receptor L3 0.430393
SRSF9 serine/arginine-rich splicing factor 9 0.424389
ADGRL1 adhesion G protein-coupled receptor L1 0.418019
LOXL2 lysyl oxidase-like 2 0.417644
VRK2 vaccinia related kinase 2 0.414276
ATP10A ATPase, class V, type 10A 0.410909
PARL presenilin associated, rhomboid-like 0.410535
ARF4 ADP-ribosylation factor 4 0.410161
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.407172
SH3PXD2B SH3 and PX domains 2B 0.406425
JCHAIN joining chain of multimeric IgA and IgM 0.404931
PER1 period circadian clock 1 0.403438
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.403064
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.403064
MATN2 matrilin 2 0.402692
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.400826
EFNA5 ephrin-A5 0.396725
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.395235
CRYAB crystallin, alpha B 0.395235
GSTA3 glutathione S-transferase alpha 3 0.395235
GSTA2 glutathione S-transferase alpha 2 0.394118
TNC tenascin C 0.387794
PRLH prolactin releasing hormone 0.387794
GSTA1 glutathione S-transferase alpha 1 0.387051
OLFML3 olfactomedin-like 3 0.383337
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.377773
ELN elastin 0.37555
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.373698
MYL9 myosin, light chain 9, regulatory 0.373328
GMDS GDP-mannose 4,6-dehydratase 0.372958
AXL AXL receptor tyrosine kinase 0.372958
SPON2 spondin 2, extracellular matrix protein 0.372587
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.368518
FMOD fibromodulin 0.36741
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.364454
AKAP13 A kinase (PRKA) anchor protein 13 0.360764
PRKCQ protein kinase C, theta 0.360026
CAT catalase 0.359657
FBXO11 F-box protein 11 0.358551
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.358551
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.355604
PHGDH phosphoglycerate dehydrogenase 0.354868
COL8A1 collagen, type VIII, alpha 1 0.35082
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.35082
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.34384
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.341639
NCK1 NCK adaptor protein 1 0.340539
DEFB4A defensin, beta 4A 0.337608
SFRP1 secreted frizzled-related protein 1 0.335778
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.334315
GSTM3 glutathione S-transferase mu 3 (brain) 0.33066
EDNRA endothelin receptor type A 0.328105
GPX4 glutathione peroxidase 4 0.328105
IL20RB interleukin 20 receptor beta 0.327375
GLB1 galactosidase, beta 1 0.326646
CALCR calcitonin receptor 0.326646
SRSF5 serine/arginine-rich splicing factor 5 0.321181
WASL Wiskott-Aldrich syndrome-like 0.319363
NRG2 neuregulin 2 0.316456
ANG angiogenin, ribonuclease, RNase A family, 5 0.312102
TP53 tumor protein p53 0.311739
MFAP2 microfibrillar-associated protein 2 0.305948
SMAD7 SMAD family member 7 0.305948
LPAR1 lysophosphatidic acid receptor 1 0.304503
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.301976
EP400 E1A binding protein p400 0.301976
GIN1 gypsy retrotransposon integrase 1 0.295132
LAMP1 lysosomal-associated membrane protein 1 0.294053
CNTN4 contactin 4 0.293694
VAV1 vav 1 guanine nucleotide exchange factor 0.279724
TNF tumor necrosis factor 0.279011
PON2 paraoxonase 2 0.275801
SRSF3 serine/arginine-rich splicing factor 3 0.273308
IL1A interleukin 1, alpha 0.269043
ANK1 ankyrin 1, erythrocytic 0.267977
GPX5 glutathione peroxidase 5 0.262306
FRZB frizzled-related protein 0.261599
VAMP8 vesicle-associated membrane protein 8 0.261599
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.261245
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.260891
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.260538
EDNRB endothelin receptor type B 0.260184
HAPLN1 hyaluronan and proteoglycan link protein 1 0.257711
TSPAN12 tetraspanin 12 0.252774
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.251718
BRWD1 bromodomain and WD repeat domain containing 1 0.250663
BAG6 BCL2-associated athanogene 6 0.249608
CDC7 cell division cycle 7 0.249608
DCN decorin 0.248554
ZNF501 zinc finger protein 501 0.245747
ZNF629 zinc finger protein 629 0.245747
ZNF569 zinc finger protein 569 0.245747
ZNF763 zinc finger protein 763 0.245747
GPX1 glutathione peroxidase 1 0.245046
NID2 nidogen 2 (osteonidogen) 0.243295
BMP3 bone morphogenetic protein 3 0.239799
IGHA1 immunoglobulin heavy constant alpha 1 0.238403
LCN1 lipocalin 1 0.237357
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.23492
ZNF44 zinc finger protein 44 0.23353
BMP5 bone morphogenetic protein 5 0.232489
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.232489
CYCS cytochrome c, somatic 0.230063
ADRB2 adrenoceptor beta 2, surface 0.226952
CISH cytokine inducible SH2-containing protein 0.226952
MGST1 microsomal glutathione S-transferase 1 0.225229
IL20RA interleukin 20 receptor, alpha 0.223509
TMC8 transmembrane channel-like 8 0.222479
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) 0.221108
SENP1 SUMO1/sentrin specific peptidase 1 0.220766
BCL6B B-cell CLL/lymphoma 6, member B 0.219057
MT-ATP8 ATP synthase F0 subunit 8 0.218374
FZD2 frizzled class receptor 2 0.218374
LTBP1 latent transforming growth factor beta binding protein 1 0.215992
TARDBP TAR DNA binding protein 0.215314
COL1A1 collagen, type I, alpha 1 0.213621
DNM2 dynamin 2 0.212945
GPR17 G protein-coupled receptor 17 0.209918
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.209918
ICA1 islet cell autoantigen 1, 69kDa 0.208579
WWTR1 WW domain containing transcription regulator 1 0.206913
FRMD6 FERM domain containing 6 0.204263
NTM neurotrimin 0.200331
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.199033
RPGR retinitis pigmentosa GTPase regulator 0.198064
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.198064
COL18A1 collagen, type XVIII, alpha 1 0.197742
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.197099
SNAP25 synaptosomal-associated protein, 25kDa 0.196459
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.195501
C1QBP complement component 1, q subcomponent binding protein 0.194232
LOX lysyl oxidase 0.193285
GAS1 growth arrest-specific 1 0.192344
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.192344
HAND2 heart and neural crest derivatives expressed 2 0.188632
HECA headcase homolog (Drosophila) 0.188632
FIG4 FIG4 phosphoinositide 5-phosphatase 0.187719
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 0.187719
RERE arginine-glutamic acid dipeptide (RE) repeats 0.18621
CA10 carbonic anhydrase X 0.185016
AQP7 aquaporin 7 0.184424
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.184128
FGF5 fibroblast growth factor 5 0.183541
GSTP1 glutathione S-transferase pi 1 0.182957
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.182666
MBP myelin basic protein 0.179802
DCLK1 doublecortin-like kinase 1 0.179239
NBPF8 neuroblastoma breakpoint family, member 8 0.177576
FUS FUS RNA binding protein 0.177029
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.175947
SOAT1 sterol O-acyltransferase 1 0.175679
CELA1 chymotrypsin-like elastase family, member 1 0.174617
ANK2 ankyrin 2, neuronal 0.173832
TGFBR3 transforming growth factor, beta receptor III 0.172291
MYO6 myosin VI 0.172038
BDNF brain-derived neurotrophic factor 0.170544
CELA3B chymotrypsin-like elastase family, member 3B 0.168148
TDP1 tyrosyl-DNA phosphodiesterase 1 0.164149
PTGFR prostaglandin F receptor (FP) 0.163938
ESM1 endothelial cell-specific molecule 1 0.162109
OGG1 8-oxoguanine DNA glycosylase 0.161716
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.161523
BCAN brevican 0.160203
LGALS8 lectin, galactoside-binding, soluble, 8 0.160021
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.15948
RAB1A RAB1A, member RAS oncogene family 0.159302
FZD7 frizzled class receptor 7 0.158951
ADRB1 adrenoceptor beta 1 0.158778
TLR4 toll-like receptor 4 0.158605
ZNF436 zinc finger protein 436 0.158434
HTT huntingtin 0.158266