primary biliary cirrhosis Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. (Human Disease Ontology, DOID_12236)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:12236
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Genes

45 genes associated with the disease primary biliary cirrhosis in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 2.27087
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 1.98052
IL12RB2 interleukin 12 receptor, beta 2 1.95956
TNPO3 transportin 3 1.88168
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.76581
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 1.7256
RPL3 ribosomal protein L3 1.69288
CLEC16A C-type lectin domain family 16, member A 1.67004
EXOC3L4 exocyst complex component 3-like 4 1.66403
RAD51B RAD51 paralog B 1.62029
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 1.60998
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 1.60875
C6ORF10 chromosome 6 open reading frame 10 1.57556
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 1.55738
ARHGAP31 Rho GTPase activating protein 31 1.55623
TMEM39A transmembrane protein 39A 1.55233
IL7R interleukin 7 receptor 1.54383
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.48714
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.48714
DENND1B DENN/MADD domain containing 1B 1.48592
PRDM16 PR domain containing 16 1.41943
PLCL2 phospholipase C-like 2 1.39396
MED1 mediator complex subunit 1 1.3869
PRICKLE1 prickle homolog 1 (Drosophila) 1.36236
COL17A1 collagen, type XVII, alpha 1 1.35872
ELMO1 engulfment and cell motility 1 1.35834
TP63 tumor protein p63 1.35309
CDK12 cyclin-dependent kinase 12 1.31262
SDK1 sidekick cell adhesion molecule 1 1.31195
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.28462
FBXL20 F-box and leucine-rich repeat protein 20 1.28041
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 1.27567
PAX3 paired box 3 1.26016
GRIK1 glutamate receptor, ionotropic, kainate 1 1.25596
CNTN5 contactin 5 1.25516
GLI3 GLI family zinc finger 3 1.24805
MANBA mannosidase, beta A, lysosomal 1.24301
STAT4 signal transducer and activator of transcription 4 1.19386
CCDC88B coiled-coil domain containing 88B 1.18637
LBH limb bud and heart development 1.15242
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.1012
HNRNPK heterogeneous nuclear ribonucleoprotein K 1.09927
C5ORF30 chromosome 5 open reading frame 30 1.02778
MAPT microtubule-associated protein tau 1.02568
COLEC12 collectin sub-family member 12 1.00332