primary biliary cirrhosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. (Human Disease Ontology, DOID_12236)
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Genes

261 genes co-occuring with the disease primary biliary cirrhosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ALPP alkaline phosphatase, placental 2.13971
ALPPL2 alkaline phosphatase, placental-like 2 2.1387
ALPL alkaline phosphatase, liver/bone/kidney 2.13718
SP100 SP100 nuclear antigen 2.05945
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1.82278
DLAT dihydrolipoamide S-acetyltransferase 1.70861
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 1.59206
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.54186
GGT1 gamma-glutamyltransferase 1 1.52204
PDHX pyruvate dehydrogenase complex, component X 1.51457
ALB albumin 1.51369
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.51369
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.49613
CD79A CD79a molecule, immunoglobulin-associated alpha 1.37556
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.32934
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.24341
F2 coagulation factor II (thrombin) 1.2382
GGT2 gamma-glutamyltransferase 2 1.22258
LBR lamin B receptor 1.20093
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 1.18324
CD4 CD4 molecule 1.16307
HLA-C major histocompatibility complex, class I, C 1.11898
IL12RB2 interleukin 12 receptor, beta 2 1.06522
CENPB centromere protein B, 80kDa 1.04209
TNPO3 transportin 3 1.01132
SP140 SP140 nuclear body protein 0.980531
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.974221
DCP1A decapping mRNA 1A 0.949519
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.918848
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.906498
TNF tumor necrosis factor 0.856905
HSPG2 heparan sulfate proteoglycan 2 0.820026
DLD dihydrolipoamide dehydrogenase 0.800744
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 0.795002
GPBAR1 G protein-coupled bile acid receptor 1 0.789262
CP ceruloplasmin (ferroxidase) 0.785574
BGLAP bone gamma-carboxyglutamate (gla) protein 0.768801
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.752085
DENND1B DENN/MADD domain containing 1B 0.746391
KRT7 keratin 7, type II 0.73746
PML promyelocytic leukemia 0.728547
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.712796
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 0.711989
CLTC clathrin, heavy chain (Hc) 0.69751
HLA-A major histocompatibility complex, class I, A 0.696306
MIRLET7A3 microRNA let-7a-3 0.685091
CD101 CD101 molecule 0.680697
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.676706
IRF5 interferon regulatory factor 5 0.674315
AFP alpha-fetoprotein 0.672722
CENPC centromere protein C 0.671925
ICAM1 intercellular adhesion molecule 1 0.671527
KRT19 keratin 19, type I 0.665563
CALCOCO2 calcium binding and coiled-coil domain 2 0.662387
HLA-B major histocompatibility complex, class I, B 0.660008
FKBP2 FK506 binding protein 2, 13kDa 0.658026
CA2 carbonic anhydrase II 0.65565
FOXP3 forkhead box P3 0.652484
TRIM21 tripartite motif containing 21 0.644981
ENAM enamelin 0.641433
C4B complement component 4B (Chido blood group) 0.639463
NCAM1 neural cell adhesion molecule 1 0.624927
DNAH8 dynein, axonemal, heavy chain 8 0.619834
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.60342
IFNA1 interferon, alpha 1 0.59991
IL23A interleukin 23, alpha subunit p19 0.593674
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.579661
ECHDC2 enoyl CoA hydratase domain containing 2 0.577327
CENPQ centromere protein Q 0.573439
ASPRV1 aspartic peptidase, retroviral-like 1 0.57305
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.571884
PIGR polymeric immunoglobulin receptor 0.561781
STAT4 signal transducer and activator of transcription 4 0.559839
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.550522
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.547419
PTH parathyroid hormone 0.547419
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.538893
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.536183
CENPT centromere protein T 0.533475
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.529222
SLCO1B1 solute carrier organic anion transporter family, member 1B1 0.51919
CXCR3 chemokine (C-X-C motif) receptor 3 0.51188
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.509192
TGFB1 transforming growth factor, beta 1 0.505356
CD68 CD68 molecule 0.504973
SUOX sulfite oxidase 0.497703
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.497321
LTF lactotransferrin 0.495411
ACTA1 actin, alpha 1, skeletal muscle 0.494648
DCP2 decapping mRNA 2 0.491215
B3GAT1 beta-1,3-glucuronyltransferase 1 0.487788
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.485505
TBXAS1 thromboxane A synthase 1 (platelet) 0.485125
ZBTB2 zinc finger and BTB domain containing 2 0.482844
IL2 interleukin 2 0.475255
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.472982
PCNA proliferating cell nuclear antigen 0.471846
TLR3 toll-like receptor 3 0.471468
IL2RA interleukin 2 receptor, alpha 0.467684
TLR4 toll-like receptor 4 0.465416
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.462016
ACSM1 acyl-CoA synthetase medium-chain family member 1 0.456355
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.455224
SOX13 SRY (sex determining region Y)-box 13 0.453716
MMEL1 membrane metallo-endopeptidase-like 1 0.450324
SLC51B solute carrier family 51, beta subunit 0.438658
ZPBP2 zona pellucida binding protein 2 0.436402
KLHL12 kelch-like family member 12 0.436026
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.433021
ASGR2 asialoglycoprotein receptor 2 0.43227
NAGS N-acetylglutamate synthase 0.431519
FASLG Fas ligand (TNF superfamily, member 6) 0.428516
NAGK N-acetylglucosamine kinase 0.424014
GSDMB gasdermin B 0.423265
MARS methionyl-tRNA synthetase 0.418394
BTBD7 BTB (POZ) domain containing 7 0.41727
ASGR1 asialoglycoprotein receptor 1 0.416521
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.412779
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.411283
TPR translocated promoter region, nuclear basket protein 0.401572
IL1B interleukin 1, beta 0.400826
NOS3 nitric oxide synthase 3 (endothelial cell) 0.398589
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.394491
TNRC6A trinucleotide repeat containing 6A 0.390025
CD1D CD1d molecule 0.388909
PRTN3 proteinase 3 0.381481
TF transferrin 0.374068
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.368888
SBDS Shwachman-Bodian-Diamond syndrome 0.365193
LAP3 leucine aminopeptidase 3 0.360764
CD40LG CD40 ligand 0.360764
MPO myeloperoxidase 0.357814
CABIN1 calcineurin binding protein 1 0.357077
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.356709
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.355972
LEMD3 LEM domain containing 3 0.354131
IL6 interleukin 6 0.349717
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.347879
CD40 CD40 molecule, TNF receptor superfamily member 5 0.343106
POU2AF1 POU class 2 associating factor 1 0.337975
TROVE2 TROVE domain family, member 2 0.33651
RPS20 ribosomal protein S20 0.335778
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 0.335412
CD86 CD86 molecule 0.335046
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.334681
MIR346 microRNA 346 0.334315
ECRP ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) pseudogene 0.334315
UMOD uromodulin 0.333218
WNT2B wingless-type MMTV integration site family, member 2B 0.33066
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.325552
ELANE elastase, neutrophil expressed 0.320454
VTCN1 V-set domain containing T cell activation inhibitor 1 0.317545
IPO13 importin 13 0.317182
AIRE autoimmune regulator 0.316456
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.314278
KLHL7 kelch-like family member 7 0.313915
CD80 CD80 molecule 0.311377
SHBG sex hormone-binding globulin 0.303059
CLEC16A C-type lectin domain family 16, member A 0.299092
PDCD1LG2 programmed cell death 1 ligand 2 0.296931
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.294772
BCHE butyrylcholinesterase 0.289386
HMGB2 high mobility group box 2 0.287952
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 0.287952
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.284728
PRF1 perforin 1 (pore forming protein) 0.284371
COL1A1 collagen, type I, alpha 1 0.282582
IL10 interleukin 10 0.282225
GSTA1 glutathione S-transferase alpha 1 0.28151
MSN moesin 0.280439
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.279367
TIMP1 TIMP metallopeptidase inhibitor 1 0.272953
TLR9 toll-like receptor 9 0.265494
PEX3 peroxisomal biogenesis factor 3 0.264077
C4A complement component 4A (Rodgers blood group) 0.264077
F8 coagulation factor VIII, procoagulant component 0.263722
NT5E 5'-nucleotidase, ecto (CD73) 0.263014
TSPO translocator protein (18kDa) 0.261245
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.261245
NELFCD negative elongation factor complex member C/D 0.260538
TFF3 trefoil factor 3 (intestinal) 0.260184
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.257358
APOE apolipoprotein E 0.255241
IL4 interleukin 4 0.253127
PYGB phosphorylase, glycogen; brain 0.252774
SOD2 superoxide dismutase 2, mitochondrial 0.250663
PYGL phosphorylase, glycogen, liver 0.249608
CIC capicua transcriptional repressor 0.247501
CLIC2 chloride intracellular channel 2 0.244345
B2M beta-2-microglobulin 0.242595
CCL19 chemokine (C-C motif) ligand 19 0.241546
CENPH centromere protein H 0.240847
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.237357
CARD10 caspase recruitment domain family, member 10 0.235964
CXCL10 chemokine (C-X-C motif) ligand 10 0.230409
GSTA3 glutathione S-transferase alpha 3 0.227988
DPP4 dipeptidyl-peptidase 4 0.227642
GSTA2 glutathione S-transferase alpha 2 0.226952
EPCAM epithelial cell adhesion molecule 0.226952
TTR transthyretin 0.226607
SP3 Sp3 transcription factor 0.226262
GSTA4 glutathione S-transferase alpha 4 0.225917
PYGM phosphorylase, glycogen, muscle 0.225573
TICAM1 toll-like receptor adaptor molecule 1 0.22454
OTC ornithine carbamoyltransferase 0.223509
CDKN2A cyclin-dependent kinase inhibitor 2A 0.223165
CCL14 chemokine (C-C motif) ligand 14 0.221108
INCENP inner centromere protein antigens 135/155kDa 0.220766
EDN1 endothelin 1 0.220766
CALR calreticulin 0.220424
RANGAP1 Ran GTPase activating protein 1 0.219398
CD19 CD19 molecule 0.218374
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.217693
LRRC32 leucine rich repeat containing 32 0.214297
OPTN optineurin 0.207245
CD44 CD44 molecule (Indian blood group) 0.206913
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 0.203604
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.201308
FN1 fibronectin 1 0.199681
LY96 lymphocyte antigen 96 0.198064
ALLC allantoicase 0.198064
IL12RB1 interleukin 12 receptor, beta 1 0.196459
NEU4 sialidase 4 0.196139
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.196139
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 0.195183
GNLY granulysin 0.194548
SQSTM1 sequestosome 1 0.194232
REXO1L1P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene 0.187719
LST1 leukocyte specific transcript 1 0.187415
C1S complement component 1, s subcomponent 0.187113
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.187113
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.183541
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.183248
SELE selectin E 0.182375
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.18151
SIAE sialic acid acetylesterase 0.181222
GIF gastric intrinsic factor (vitamin B synthesis) 0.179239
CD69 CD69 molecule 0.178682
DMBT1 deleted in malignant brain tumors 1 0.178682
CCL21 chemokine (C-C motif) ligand 21 0.177851
CD1C CD1c molecule 0.177576
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.177029
CCL2 chemokine (C-C motif) ligand 2 0.175947
SARDH sarcosine dehydrogenase 0.175679
PPARA peroxisome proliferator-activated receptor alpha 0.175146
CBX3 chromobox homolog 3 0.175146
PMF1 polyamine-modulated factor 1 0.174617
GLB1 galactosidase, beta 1 0.172038
CENPJ centromere protein J 0.171785
SNN stannin 0.171036
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.170789
TPM1 tropomyosin 1 (alpha) 0.168617
ELOVL2 ELOVL fatty acid elongase 2 0.166544
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.166095
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.165874
APOB apolipoprotein B 0.165217
LIG3 ligase III, DNA, ATP-dependent 0.164149
BORA bora, aurora kinase A activator 0.163729
ALPI alkaline phosphatase, intestinal 0.161139
CCR7 chemokine (C-C motif) receptor 7 0.160574
KRT8 keratin 8, type II 0.15948