presynaptic membrane Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. (Gene Ontology, GO_0042734)
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Genes

133 proteins co-occuring with the presynaptic membrane cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 1.4069
STX1A syntaxin 1A (brain) 1.38905
BSN bassoon presynaptic cytomatrix protein 1.33576
NSF N-ethylmaleimide-sensitive factor 1.22205
SYP synaptophysin 1.13574
UNC13A unc-13 homolog A (C. elegans) 1.09696
RAB3A RAB3A, member RAS oncogene family 1.07816
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 1.01883
ERC2 ELKS/RAB6-interacting/CAST family member 2 1.01337
SYN1 synapsin I 0.955439
RNASE13 ribonuclease, RNase A family, 13 (non-active) 0.918111
SYT1 synaptotagmin I 0.906926
STXBP1 syntaxin binding protein 1 0.904138
GAP43 growth associated protein 43 0.856176
SNAP23 synaptosomal-associated protein, 23kDa 0.854798
RIMS1 regulating synaptic membrane exocytosis 1 0.821288
NRXN1 neurexin 1 0.802938
TRIM9 tripartite motif containing 9 0.801104
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 0.793771
LIN7C lin-7 homolog C (C. elegans) 0.785071
ACHE acetylcholinesterase (Yt blood group) 0.757707
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.738263
UNC13B unc-13 homolog B (C. elegans) 0.723472
PLA2G1B phospholipase A2, group IB (pancreas) 0.699103
PRRT2 proline-rich transmembrane protein 2 0.689013
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.658188
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.656464
NRGN neurogranin (protein kinase C substrate, RC3) 0.654311
GPR162 G protein-coupled receptor 162 0.629465
SRCIN1 SRC kinase signaling inhibitor 1 0.627335
PCLO piccolo presynaptic cytomatrix protein 0.624355
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.615861
UNC13C unc-13 homolog C (C. elegans) 0.614165
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.603596
IGKV1-17 immunoglobulin kappa variable 1-17 0.595173
BCHE butyrylcholinesterase 0.585105
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.566338
SH3GL2 SH3-domain GRB2-like 2 0.545648
DNAH8 dynein, axonemal, heavy chain 8 0.524294
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.518981
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.506757
CNR1 cannabinoid receptor 1 (brain) 0.499853
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.49418
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.485289
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.477233
GPM6A glycoprotein M6A 0.475625
STX4 syntaxin 4 0.473215
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.471609
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.469203
GRM1 glutamate receptor, metabotropic 1 0.465198
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.453223
ADAM23 ADAM metallopeptidase domain 23 0.448848
CA4 carbonic anhydrase IV 0.443689
PRNP prion protein 0.428284
PICK1 protein interacting with PRKCA 1 0.418468
UNC119 unc-119 homolog (C. elegans) 0.41612
SYN3 synapsin III 0.408699
RIMS2 regulating synaptic membrane exocytosis 2 0.407919
ADAM28 ADAM metallopeptidase domain 28 0.407529
STX5 syntaxin 5 0.402081
KIF3A kinesin family member 3A 0.393936
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.393162
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 0.392388
SNPH syntaphilin 0.388523
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.37505
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.374283
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.353282
NXN nucleoredoxin 0.352522
ADAM22 ADAM metallopeptidase domain 22 0.352142
SCAMP2 secretory carrier membrane protein 2 0.351002
GRM5 glutamate receptor, metabotropic 5 0.351002
KIAA0101 KIAA0101 0.348346
GRM2 glutamate receptor, metabotropic 2 0.343421
SHPK sedoheptulokinase 0.337373
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 0.326453
ANO2 anoctamin 2, calcium activated chloride channel 0.316708
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.312224
MUSK muscle, skeletal, receptor tyrosine kinase 0.307749
CHAT choline O-acetyltransferase 0.307377
GUK1 guanylate kinase 1 0.298826
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.295119
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.294748
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.294748
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.294748
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.293267
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.286614
CABP1 calcium binding protein 1 0.284032
ASIC2 acid sensing (proton gated) ion channel 2 0.281453
NPS neuropeptide S 0.279612
LGI1 leucine-rich, glioma inactivated 1 0.279612
RAB3C RAB3C, member RAS oncogene family 0.267871
STON2 stonin 2 0.263485
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.26239
DNM1 dynamin 1 0.259109
MGAM maltase-glucoamylase 0.251476
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.243519
STX1B syntaxin 1B 0.243519
KIF5A kinesin family member 5A 0.240996
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.239557
CA1 carbonic anhydrase I 0.237401
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.237042
CALU calumenin 0.237042
SPTBN4 spectrin, beta, non-erythrocytic 4 0.231672
HEXA hexosaminidase A (alpha polypeptide) 0.226331
SPTA1 spectrin, alpha, erythrocytic 1 0.225622
NRTN neurturin 0.217861
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.21681
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.216111
APLP1 amyloid beta (A4) precursor-like protein 1 0.214714
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.213669
TH tyrosine hydroxylase 0.21228
SV2B synaptic vesicle glycoprotein 2B 0.209513
CPLX1 complexin 1 0.209513
HSF2 heat shock transcription factor 2 0.203699
TARP TCR gamma alternate reading frame protein 0.197662
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.196999
MLYCD malonyl-CoA decarboxylase 0.194698
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.192423
SEPT6 septin 6 0.192423
GRM7 glutamate receptor, metabotropic 7 0.190495
TAC1 tachykinin, precursor 1 0.183328
STXBP3 syntaxin binding protein 3 0.18093
NLGN1 neuroligin 1 0.167856
ASIC1 acid sensing (proton gated) ion channel 1 0.167856
PRIMA1 proline rich membrane anchor 1 0.167366
CNTN5 contactin 5 0.167125
SYN2 synapsin II 0.166167
TNR tenascin R 0.166167
SNAP25 synaptosomal-associated protein, 25kDa 0.163641
SNAPIN SNAP-associated protein 0.16298
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.161068
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.160456
GRM4 glutamate receptor, metabotropic 4 0.158502