presynaptic cytoskeletal matrix assembled at active zones Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites. (Gene Ontology, GO_0048788)
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165 proteins co-occuring with the presynaptic cytoskeletal matrix assembled at active zones cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BSN bassoon presynaptic cytomatrix protein 1.92716
GPX5 glutathione peroxidase 5 1.65513
GPX4 glutathione peroxidase 4 1.64613
GPX1 glutathione peroxidase 1 1.63717
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.53896
SOD2 superoxide dismutase 2, mitochondrial 1.49718
CTBP2 C-terminal binding protein 2 1.49436
CAT catalase 1.48871
PHF20 PHD finger protein 20 1.19365
HSF4 heat shock transcription factor 4 1.18903
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 1.09493
UNC13A unc-13 homolog A (C. elegans) 1.0873
LIF leukemia inhibitory factor 1.08679
ERC1 ELKS/RAB6-interacting/CAST family member 1 1.06195
GSR glutathione reductase 1.04381
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 1.0423
AANAT aralkylamine N-acetyltransferase 1.0238
RIMS1 regulating synaptic membrane exocytosis 1 1.01585
TOB1 transducer of ERBB2, 1 0.994652
CABP4 calcium binding protein 4 0.950189
PCLO piccolo presynaptic cytomatrix protein 0.939269
PDZD11 PDZ domain containing 11 0.846532
CTBP1 C-terminal binding protein 1 0.815781
G6PD glucose-6-phosphate dehydrogenase 0.813028
OTOF otoferlin 0.807982
ZNF224 zinc finger protein 224 0.803855
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.800645
KLK4 kallikrein-related peptidase 4 0.796979
RIMS2 regulating synaptic membrane exocytosis 2 0.775928
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.765438
CPLX3 complexin 3 0.726599
EFHC2 EF-hand domain (C-terminal) containing 2 0.715902
SYP synaptophysin 0.703949
ANTXR1 anthrax toxin receptor 1 0.696026
GNG13 guanine nucleotide binding protein (G protein), gamma 13 0.692955
KIF3A kinesin family member 3A 0.670725
RCVRN recoverin 0.668126
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.656895
CD248 CD248 molecule, endosialin 0.638861
IQSEC2 IQ motif and Sec7 domain 2 0.622654
IAPP islet amyloid polypeptide 0.617982
FUS FUS RNA binding protein 0.617133
MMP20 matrix metallopeptidase 20 0.616285
CNOT8 CCR4-NOT transcription complex, subunit 8 0.598538
GPR179 G protein-coupled receptor 179 0.596014
COPG1 coatomer protein complex, subunit gamma 1 0.589295
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.581758
AMBN ameloblastin (enamel matrix protein) 0.58134
HTRA3 HtrA serine peptidase 3 0.576329
ASMT acetylserotonin O-methyltransferase 0.575078
CPLX4 complexin 4 0.574244
WIBG within bgcn homolog (Drosophila) 0.569248
AMELX amelogenin, X-linked 0.568001
ENAM enamelin 0.544411
PROZ protein Z, vitamin K-dependent plasma glycoprotein 0.541117
EFHC1 EF-hand domain (C-terminal) containing 1 0.525113
TULP1 tubby like protein 1 0.520615
ALB albumin 0.51694
APOC2 apolipoprotein C-II 0.503912
MPO myeloperoxidase 0.501476
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.500258
PHF6 PHD finger protein 6 0.500258
PKDCC protein kinase domain containing, cytoplasmic 0.49418
GUCA1B guanylate cyclase activator 1B (retina) 0.49418
RGS11 regulator of G-protein signaling 11 0.491348
IQSEC3 IQ motif and Sec7 domain 3 0.48287
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.479647
FBLIM1 filamin binding LIM protein 1 0.476027
GCDH glutaryl-CoA dehydrogenase 0.475223
AMELY amelogenin, Y-linked 0.474018
MGAM maltase-glucoamylase 0.465598
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.465598
CHGA chromogranin A 0.459602
RD3 retinal degeneration 3 0.446862
REG1B regenerating islet-derived 1 beta 0.442104
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.441312
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.438937
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.434985
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.431041
IQSEC1 IQ motif and Sec7 domain 1 0.412992
VEZF1 vascular endothelial zinc finger 1 0.41143
ATM ATM serine/threonine kinase 0.382354
MAGEE1 melanoma antigen family E1 0.378891
RPS19BP1 ribosomal protein S19 binding protein 1 0.377354
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 0.375818
UNC13B unc-13 homolog B (C. elegans) 0.374283
GSTA3 glutathione S-transferase alpha 3 0.362804
GSTA2 glutathione S-transferase alpha 2 0.361277
GSTA4 glutathione S-transferase alpha 4 0.360896
GSTA1 glutathione S-transferase alpha 1 0.358609
CABP2 calcium binding protein 2 0.355563
HAND2 heart and neural crest derivatives expressed 2 0.355183
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.337751
AVPR2 arginine vasopressin receptor 2 0.336996
LRRC4 leucine rich repeat containing 4 0.334356
MAPT microtubule-associated protein tau 0.332095
SCN10A sodium channel, voltage gated, type X alpha subunit 0.327581
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.327205
FEZF1 FEZ family zinc finger 1 0.326078
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.318579
WDR92 WD repeat domain 92 0.307377
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.307004
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.304399
F2 coagulation factor II (thrombin) 0.296601
FEZF2 FEZ family zinc finger 2 0.29623
CALB1 calbindin 1, 28kDa 0.290678
VSX2 visual system homeobox 2 0.288829
GRM7 glutamate receptor, metabotropic 7 0.285507
POU4F1 POU class 4 homeobox 1 0.283663
ELANE elastase, neutrophil expressed 0.282189
NYX nyctalopin 0.282189
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.280716
NTNG2 netrin G2 0.277038
SYNJ1 synaptojanin 1 0.277038
SRR serine racemase 0.277038
GRM6 glutamate receptor, metabotropic 6 0.274101
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.265677
RHO rhodopsin 0.265311
OPLAH 5-oxoprolinase (ATP-hydrolysing) 0.264581
FAM134B family with sequence similarity 134, member B 0.262755
TUFT1 tuftelin 1 0.261296
GGT1 gamma-glutamyltransferase 1 0.260566
GIN1 gypsy retrotransposon integrase 1 0.258016
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.256925
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.251476
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.250751
DNAH8 dynein, axonemal, heavy chain 8 0.249302
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.248216
TH tyrosine hydroxylase 0.246046
ENO2 enolase 2 (gamma, neuronal) 0.241356
FBL fibrillarin 0.240996
HBE1 hemoglobin, epsilon 1 0.239197
CHURC1 churchill domain containing 1 0.239197
XYLT1 xylosyltransferase I 0.238837
CS citrate synthase 0.235249
CADM1 cell adhesion molecule 1 0.231672
BDNF brain-derived neurotrophic factor 0.229176
PFN2 profilin 2 0.227752
LIAS lipoic acid synthetase 0.222436
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.222436
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.222436
KIRREL2 kin of IRRE like 2 (Drosophila) 0.217861
LIN7C lin-7 homolog C (C. elegans) 0.21681
NGEF neuronal guanine nucleotide exchange factor 0.215412
RGN regucalcin 0.210549
SPAG9 sperm associated antigen 9 0.208825
KRT36 keratin 36, type I 0.208481
PAH phenylalanine hydroxylase 0.205059
SAG S-antigen; retina and pineal gland (arrestin) 0.200328
EPHB3 EPH receptor B3 0.190814
S1PR4 sphingosine-1-phosphate receptor 4 0.190495
CLDN14 claudin 14 0.189222
CRP C-reactive protein, pentraxin-related 0.184241
GAST gastrin 0.181823
SFTPA2 surfactant protein A2 0.176587
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.176587
GSTM2 glutathione S-transferase mu 2 (muscle) 0.171149
CD14 CD14 molecule 0.170371
EFNA5 ephrin-A5 0.170114
EPHA4 EPH receptor A4 0.168349
C6ORF25 chromosome 6 open reading frame 25 0.165697
FBLL1 fibrillarin-like 1 0.163641
SNN stannin 0.1632
DBNL drebrin-like 0.16233
ARR3 arrestin 3, retinal (X-arrestin) 0.158882