premature ovarian failure Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. (Human Disease Ontology, DOID_5426)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:5426
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Genes

101 genes associated with the disease premature ovarian failure in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 1.23056
MCC mutated in colorectal cancers 0.778355
PLXDC2 plexin domain containing 2 0.729592
DCP2 decapping mRNA 2 0.714752
SCARA5 scavenger receptor class A, member 5 0.713355
NEK11 NIMA-related kinase 11 0.680678
PUM2 pumilio RNA-binding family member 2 0.669341
PERP PERP, TP53 apoptosis effector 0.660239
KIAA1217 KIAA1217 0.636511
ZNF831 zinc finger protein 831 0.626876
CSMD1 CUB and Sushi multiple domains 1 0.62609
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.624931
FNDC3B fibronectin type III domain containing 3B 0.61742
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.616096
EPHA4 EPH receptor A4 0.614766
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.614416
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.607188
VCL vinculin 0.605962
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.596808
NPAP1 nuclear pore associated protein 1 0.590323
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.590323
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.589304
CADM2 cell adhesion molecule 2 0.588302
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.588302
SACS sacsin molecular chaperone 0.583062
HEG1 heart development protein with EGF-like domains 1 0.580283
NUP98 nucleoporin 98kDa 0.57934
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.579107
MAPK14 mitogen-activated protein kinase 14 0.56878
WDR26 WD repeat domain 26 0.568383
DOCK1 dedicator of cytokinesis 1 0.566821
LRP1B low density lipoprotein receptor-related protein 1B 0.564734
NIN ninein (GSK3B interacting protein) 0.563041
AQP9 aquaporin 9 0.562261
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.561875
BAHCC1 BAH domain and coiled-coil containing 1 0.561682
HUNK hormonally up-regulated Neu-associated kinase 0.560539
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.55338
PRKG1 protein kinase, cGMP-dependent, type I 0.551538
SPAG17 sperm associated antigen 17 0.550231
PVT1 Pvt1 oncogene (non-protein coding) 0.549587
PTCRA pre T-cell antigen receptor alpha 0.549107
PDGFD platelet derived growth factor D 0.548003
CACHD1 cache domain containing 1 0.54431
CSMD2 CUB and Sushi multiple domains 2 0.54431
GRID2 glutamate receptor, ionotropic, delta 2 0.541974
PARD3B par-3 family cell polarity regulator beta 0.541668
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.541364
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.540459
MR1 major histocompatibility complex, class I-related 0.54016
SASH1 SAM and SH3 domain containing 1 0.537098
IGF2R insulin-like growth factor 2 receptor 0.536388
NCKAP5 NCK-associated protein 5 0.535269
FRYL FRY-like 0.534167
NELL2 NEL-like 2 (chicken) 0.533623
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.532681
SLC44A3 solute carrier family 44, member 3 0.532016
PAX8 paired box 8 0.53162
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.530835
HELQ helicase, POLQ-like 0.529293
BTBD9 BTB (POZ) domain containing 9 0.528409
KIAA0226L KIAA0226-like 0.528284
ATP8B4 ATPase, class I, type 8B, member 4 0.527909
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.526921
LOXHD1 lipoxygenase homology domains 1 0.526554
TUBA8 tubulin, alpha 8 0.524388
DOCK2 dedicator of cytokinesis 2 0.523564
NLGN1 neuroligin 1 0.523213
MAP3K6 mitogen-activated protein kinase kinase kinase 6 0.522749
ZDHHC14 zinc finger, DHHC-type containing 14 0.521603
CYYR1 cysteine/tyrosine-rich 1 0.520253
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.520253
DROSHA drosha, ribonuclease type III 0.516466
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.51532
TPRG1 tumor protein p63 regulated 1 0.514193
ESPNL espin-like 0.513889
INTS9 integrator complex subunit 9 0.511898
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.510636
WWOX WW domain containing oxidoreductase 0.508927
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.508461
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.508368
MYOM2 myomesin 2 0.506176
BDNF-AS BDNF antisense RNA 0.505403
DNHD1 dynein heavy chain domain 1 0.505055
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 0.502816
PTPRT protein tyrosine phosphatase, receptor type, T 0.502816
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.502091
MGC27382 uncharacterized MGC27382 0.501829
MST1 macrophage stimulating 1 0.500669
THSD4 thrombospondin, type I, domain containing 4 0.500478
PKD1L1 polycystic kidney disease 1 like 1 0.500035
FRMD4A FERM domain containing 4A 0.49991
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.49991
GPR158 G protein-coupled receptor 158 0.498607
DISC1 disrupted in schizophrenia 1 0.498607
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.498424
MYO5C myosin VC 0.49818
C5ORF22 chromosome 5 open reading frame 22 0.49818
SCFD2 sec1 family domain containing 2 0.497877
TBX15 T-box 15 0.497817
TMEM164 transmembrane protein 164 0.497456