premature ovarian failure Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. (Human Disease Ontology, DOID_5426)
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Genes

202 genes co-occuring with the disease premature ovarian failure in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FOXL2 forkhead box L2 2.52276
GDF9 growth differentiation factor 9 2.23513
BMP15 bone morphogenetic protein 15 2.17337
FMR1 fragile X mental retardation 1 2.15561
FSHR follicle stimulating hormone receptor 2.13416
NOBOX NOBOX oogenesis homeobox 2.0943
FOXP2 forkhead box P2 1.793
AMH anti-Mullerian hormone 1.77857
FIGLA folliculogenesis specific basic helix-loop-helix 1.75958
POF1B premature ovarian failure, 1B 1.65475
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.62291
GPR3 G protein-coupled receptor 3 1.5934
INHA inhibin, alpha 1.55026
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 1.44606
LHX8 LIM homeobox 8 1.33938
DIAPH2 diaphanous-related formin 2 1.33589
DACH2 dachshund family transcription factor 2 1.32672
TRIM61 tripartite motif containing 61 1.30882
GALT galactose-1-phosphate uridylyltransferase 1.19618
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 1.16692
RFPL4A ret finger protein-like 4A 1.16307
H1FOO H1 histone family, member O, oocyte-specific 1.16307
FER1L6 fer-1-like family member 6 1.16307
NANOS3 nanos homolog 3 (Drosophila) 1.09587
STAG3 stromal antigen 3 1.07782
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 1.0774
BRSK1 BR serine/threonine kinase 1 1.03662
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 1.00161
NXF5 nuclear RNA export factor 5 0.979268
TGFBR3 transforming growth factor, beta receptor III 0.959542
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.958705
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 0.956614
TRIM40 tripartite motif containing 40 0.956614
FOXO3 forkhead box O3 0.954943
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.949519
MEIG1 meiosis/spermiogenesis associated 1 0.927105
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.920085
SYCE1 synaptonemal complex central element protein 1 0.905675
NLRP5 NLR family, pyrin domain containing 5 0.897461
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.88393
PABPC5 poly(A) binding protein, cytoplasmic 5 0.877786
ZBTB7C zinc finger and BTB domain containing 7C 0.8741
SPO11 SPO11 meiotic protein covalently bound to DSB 0.869596
CLSTN2 calsyntenin 2 0.859771
SHBG sex hormone-binding globulin 0.857315
KITLG KIT ligand 0.856497
RNF10 ring finger protein 10 0.852811
INHBB inhibin, beta B 0.847488
MSH4 mutS homolog 4 0.839296
DAZL deleted in azoospermia-like 0.829869
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.825768
ZFX zinc finger protein, X-linked 0.812642
TOX2 TOX high mobility group box family member 2 0.795411
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.792131
GTSF1 gametocyte specific factor 1 0.790902
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.787623
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.770027
SPIN1 spindlin 1 0.768801
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.768801
NANOS1 nanos homolog 1 (Drosophila) 0.763086
NXF3 nuclear RNA export factor 3 0.758601
GTDC1 glycosyltransferase-like domain containing 1 0.75412
AR androgen receptor 0.749644
PARD6B par-6 family cell polarity regulator beta 0.719654
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.715215
AIRE autoimmune regulator 0.714408
OSR2 odd-skipped related transciption factor 2 0.707559
ACSL6 acyl-CoA synthetase long-chain family member 6 0.691094
PGRMC1 progesterone receptor membrane component 1 0.690293
ARHGAP15 Rho GTPase activating protein 15 0.685491
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.682294
MRPS22 mitochondrial ribosomal protein S22 0.677504
UMODL1 uromodulin-like 1 0.674713
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.666358
NANOS2 nanos homolog 2 (Drosophila) 0.660008
AFF2 AF4/FMR2 family, member 2 0.645375
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 0.638676
SHOX short stature homeobox 0.637889
FNDC1 fibronectin type III domain containing 1 0.620226
ESR1 estrogen receptor 1 0.61866
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.616312
PSMC3IP PSMC3 interacting protein 0.614747
SGMS2 sphingomyelin synthase 2 0.608104
DMRT1 doublesex and mab-3 related transcription factor 1 0.605372
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.60186
PRL prolactin 0.598351
SERBP1 SERPINE1 mRNA binding protein 1 0.597961
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.595233
USP9X ubiquitin specific peptidase 9, X-linked 0.591337
AMER1 APC membrane recruitment protein 1 0.591337
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.590948
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 0.576939
FST follistatin 0.576939
PTEN phosphatase and tensin homolog 0.574217
POLG polymerase (DNA directed), gamma 0.541992
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.536957
ESR2 estrogen receptor 2 (ER beta) 0.534248
FNDC3B fibronectin type III domain containing 3B 0.528063
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 0.508808
FOXE1 forkhead box E1 0.508041
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.50689
RSPO1 R-spondin 1 0.501909
HDX highly divergent homeobox 0.487027
NPAS4 neuronal PAS domain protein 4 0.485125
SAMD9 sterile alpha motif domain containing 9 0.483985
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.477151
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 0.472982
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.469576
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.46466
NXF2 nuclear RNA export factor 2 0.459373
NXF2B nuclear RNA export factor 2B 0.459373
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.457487
IRX6 iroquois homeobox 6 0.455601
PAEP progestagen-associated endometrial protein 0.449194
SOX9 SRY (sex determining region Y)-box 9 0.445805
STRA8 stimulated by retinoic acid 8 0.42664
BBS9 Bardet-Biedl syndrome 9 0.424389
PMM2 phosphomannomutase 2 0.424389
PCM1 pericentriolar material 1 0.42289
DLX6 distal-less homeobox 6 0.410161
RBBP8 retinoblastoma binding protein 8 0.407545
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.404931
GALK1 galactokinase 1 0.404931
NOG noggin 0.396353
KISS1R KISS1 receptor 0.389281
GDF3 growth differentiation factor 3 0.386679
LHCGR luteinizing hormone/choriogonadotropin receptor 0.382223
IRX3 iroquois homeobox 3 0.381852
IGF1 insulin-like growth factor 1 (somatomedin C) 0.379997
VMP1 vacuole membrane protein 1 0.378514
PHGDH phosphoglycerate dehydrogenase 0.376661
TSHB thyroid stimulating hormone, beta 0.369258
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.364824
IGFBP3 insulin-like growth factor binding protein 3 0.357077
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.350084
AGO2 argonaute RISC catalytic component 2 0.345675
RB1CC1 RB1-inducible coiled-coil 1 0.340539
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.339073
LIN7A lin-7 homolog A (C. elegans) 0.337242
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.335778
CLDN6 claudin 6 0.334681
STAR steroidogenic acute regulatory protein 0.331391
MSH5 mutS homolog 5 0.317182
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.312102
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.311739
SRY sex determining region Y 0.309204
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.307757
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.305948
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.303059
POMC proopiomelanocortin 0.296211
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.294772
TG thyroglobulin 0.28831
IGF2R insulin-like growth factor 2 receptor 0.28294
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.281153
SP6 Sp6 transcription factor 0.279011
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.27794
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.27153
CCND2 cyclin D2 0.267977
INHBA inhibin, beta A 0.264785
BMP5 bone morphogenetic protein 5 0.253127
CD4 CD4 molecule 0.252422
PTER phosphotriesterase related 0.251366
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.247852
ATM ATM serine/threonine kinase 0.247852
MNX1 motor neuron and pancreas homeobox 1 0.243995
LRP4 low density lipoprotein receptor-related protein 4 0.241546
PIAS1 protein inhibitor of activated STAT, 1 0.240847
RPS6 ribosomal protein S6 0.23492
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 0.232836
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.22937
GGN gametogenetin 0.229024
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.223853
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.223509
DAZ1 deleted in azoospermia 1 0.217012
HIF3A hypoxia inducible factor 3, alpha subunit 0.216672
WNT3 wingless-type MMTV integration site family, member 3 0.214297
ZFY zinc finger protein, Y-linked 0.196779
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.195501
PDPK1 3-phosphoinositide dependent protein kinase 1 0.194232
COL4A6 collagen, type IV, alpha 6 0.191408
HDAC5 histone deacetylase 5 0.190786
LHB luteinizing hormone beta polypeptide 0.190786
DHH desert hedgehog 0.188632
GCLM glutamate-cysteine ligase, modifier subunit 0.187113
ENO1 enolase 1, (alpha) 0.185313
LIG3 ligase III, DNA, ATP-dependent 0.182666
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.181798
DAZ2 deleted in azoospermia 2 0.181222
FBLN1 fibulin 1 0.179802
MCM8 minichromosome maintenance complex component 8 0.178403
PCSK1 proprotein convertase subtilisin/kexin type 1 0.177576
DLX5 distal-less homeobox 5 0.176757
NRF1 nuclear respiratory factor 1 0.174881
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.174881
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.172291
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.171785
SOX3 SRY (sex determining region Y)-box 3 0.166319
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.163729
GREM1 gremlin 1, DAN family BMP antagonist 0.161912
POU5F1B POU class 5 homeobox 1B 0.161523
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.161139
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.15948