pre-eclampsia Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. (Human Disease Ontology, DOID_10591)
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Genes

79 genes associated with the disease pre-eclampsia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACVR2A activin A receptor, type IIA
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
CAPN10 calpain 10
CFH complement factor H
COMT catechol-O-methyltransferase
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
EDN1 endothelin 1
EGF epidermal growth factor
ENG endoglin
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FSHR follicle stimulating hormone receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRK4 G protein-coupled receptor kinase 4
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
IDO1 indoleamine 2,3-dioxygenase 1
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
INHA inhibin, alpha
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LPL lipoprotein lipase
MBL2 mannose-binding lectin (protein C) 2, soluble
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
UTS2 urotensin 2
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1