pre-b acute lymphoblastic leukemia cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The most common subtype, consisting of small uniform lymphoblasts that do not synthesize complete functional immunoglobulins. The term has sometimes been restricted to the minority of the larger group that synthesize heavy chains of immunoglobulins. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001094)
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Genes

286 proteins co-occuring with the tissue pre-b acute lymphoblastic leukemia cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
LHX4 LIM homeobox 4 1.02513
BLNK B-cell linker 0.970253
EPHA3 EPH receptor A3 0.954271
DUSP1 dual specificity phosphatase 1 0.934054
PBX1 pre-B-cell leukemia homeobox 1 0.796458
EFNA5 ephrin-A5 0.787716
STAT5B signal transducer and activator of transcription 5B 0.665995
TCF3 transcription factor 3 0.601283
JAK3 Janus kinase 3 0.592845
WNT3A wingless-type MMTV integration site family, member 3A 0.494136
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.464948
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.439342
CD19 CD19 molecule 0.422618
CD59 CD59 molecule, complement regulatory protein 0.415053
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.413912
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.402523
SYK spleen tyrosine kinase 0.391553
OSGEP O-sialoglycoprotein endopeptidase 0.380627
CCNB1 cyclin B1 0.377996
PTPRC protein tyrosine phosphatase, receptor type, C 0.367876
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.351114
PTPRD protein tyrosine phosphatase, receptor type, D 0.345928
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.34371
MME membrane metallo-endopeptidase 0.322414
IL2 interleukin 2 0.294581
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.292436
IGHD3-10 immunoglobulin heavy diversity 3-10 0.277599
PREB prolactin regulatory element binding 0.272649
BCR breakpoint cluster region 0.262596
EVPL envoplakin 0.258051
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.256234
POU2F2 POU class 2 homeobox 2 0.250209
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.250162
TP53 tumor protein p53 0.239007
MAPK8 mitogen-activated protein kinase 8 0.234878
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 0.23365
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.23176
JAK2 Janus kinase 2 0.23176
LDLR low density lipoprotein receptor 0.231482
LYN LYN proto-oncogene, Src family tyrosine kinase 0.221127
BTK Bruton agammaglobulinemia tyrosine kinase 0.219171
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.216788
G6PD glucose-6-phosphate dehydrogenase 0.216126
CD24 CD24 molecule 0.214873
IGHV4-39 immunoglobulin heavy variable 4-39 0.210581
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.210225
PCDHGA12 protocadherin gamma subfamily A, 12 0.209305
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.209138
CHL1 cell adhesion molecule L1-like 0.207464
CD34 CD34 molecule 0.203988
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.20236
CD9 CD9 molecule 0.20173
IL1A interleukin 1, alpha 0.20122
CD79B CD79b molecule, immunoglobulin-associated beta 0.20001
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.199998
HDAC9 histone deacetylase 9 0.19869
RGS16 regulator of G-protein signaling 16 0.198594
ATRIP ATR interacting protein 0.198366
CADM1 cell adhesion molecule 1 0.198283
IGLV7-43 immunoglobulin lambda variable 7-43 0.197574
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.1975
CD82 CD82 molecule 0.196684
KMT2A lysine (K)-specific methyltransferase 2A 0.19667
CXCL12 chemokine (C-X-C motif) ligand 12 0.196545
FN1 fibronectin 1 0.196486
NELFB negative elongation factor complex member B 0.196429
RAB5C RAB5C, member RAS oncogene family 0.196276
DNTT DNA nucleotidylexotransferase 0.19597
VCAM1 vascular cell adhesion molecule 1 0.195644
PNMA6A paraneoplastic Ma antigen family member 6A 0.195591
PAX5 paired box 5 0.19549
MUS81 MUS81 structure-specific endonuclease subunit 0.195401
LIG4 ligase IV, DNA, ATP-dependent 0.195359
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.194979
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.194948
IGHV3-30 immunoglobulin heavy variable 3-30 0.194742
TOP2B topoisomerase (DNA) II beta 180kDa 0.194661
IRF2 interferon regulatory factor 2 0.194569
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.194388
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.194252
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.194155
ANXA5 annexin A5 0.194038
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.193942
CCRL2 chemokine (C-C motif) receptor-like 2 0.193845
FPGS folylpolyglutamate synthase 0.193779
FLT3 fms-related tyrosine kinase 3 0.193771
BCL2L1 BCL2-like 1 0.193712
CD7 CD7 molecule 0.193515
LRP1B low density lipoprotein receptor-related protein 1B 0.193186
SIGLEC10 sialic acid binding Ig-like lectin 10 0.193135
BATF basic leucine zipper transcription factor, ATF-like 0.192999
MMP28 matrix metallopeptidase 28 0.192964
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.192874
NKX6-1 NK6 homeobox 1 0.19283
JAK1 Janus kinase 1 0.192821
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.192821
TOM1 target of myb1 (chicken) 0.192782
ITGA6 integrin, alpha 6 0.192711
PIF1 PIF1 5'-to-3' DNA helicase 0.192676
CD47 CD47 molecule 0.192631
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 0.192618
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.19251
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.192469
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.192428
HOXB8 homeobox B8 0.192387
CD72 CD72 molecule 0.192364
GCAT glycine C-acetyltransferase 0.192043
FAF1 Fas (TNFRSF6) associated factor 1 0.191904
BAX BCL2-associated X protein 0.191895
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.191885
RECQL4 RecQ protein-like 4 0.191846
IL3 interleukin 3 0.191725
HDAC1 histone deacetylase 1 0.191487
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 0.191412
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.19133
MSH2 mutS homolog 2 0.191249
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.191238
SLC4A3 solute carrier family 4 (anion exchanger), member 3 0.191228
CD22 CD22 molecule 0.191073
MCM4 minichromosome maintenance complex component 4 0.190957
HOXB5 homeobox B5 0.19091
ULBP2 UL16 binding protein 2 0.190663
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.190527
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.19031
DCLRE1C DNA cross-link repair 1C 0.19022
PAPD7 PAP associated domain containing 7 0.190186
PTPRA protein tyrosine phosphatase, receptor type, A 0.190129
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.18998
WAS Wiskott-Aldrich syndrome 0.189875
VPREB1 pre-B lymphocyte 1 0.189651
ZFP36 ZFP36 ring finger protein 0.189621
IGHV4-34 immunoglobulin heavy variable 4-34 0.189586
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.189562
HECA headcase homolog (Drosophila) 0.189477
PLCG1 phospholipase C, gamma 1 0.189275
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.189269
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.189101
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.188719
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.188654
NFIL3 nuclear factor, interleukin 3 regulated 0.188562
CCND2 cyclin D2 0.188463
BCL2 B-cell CLL/lymphoma 2 0.188309
GRB2 growth factor receptor-bound protein 2 0.188248
MIR22 microRNA 22 0.188214
FYN FYN proto-oncogene, Src family tyrosine kinase 0.188146
EED embryonic ectoderm development 0.188146
IL1RN interleukin 1 receptor antagonist 0.188119
POU2AF1 POU class 2 associating factor 1 0.187536
CDK4 cyclin-dependent kinase 4 0.187464
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 0.187088
SELENBP1 selenium binding protein 1 0.186967
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.186876
CXCR4 chemokine (C-X-C motif) receptor 4 0.186645
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.186448
DEK DEK proto-oncogene 0.186393
MAPK3 mitogen-activated protein kinase 3 0.186159
SELL selectin L 0.185855
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.185661
PTPRF protein tyrosine phosphatase, receptor type, F 0.185517
DHODH dihydroorotate dehydrogenase (quinone) 0.185309
TSPO translocator protein (18kDa) 0.185309
NFYA nuclear transcription factor Y, alpha 0.185212
P4HB prolyl 4-hydroxylase, beta polypeptide 0.185034
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.185008
CDK2 cyclin-dependent kinase 2 0.184836
CSPG4 chondroitin sulfate proteoglycan 4 0.184736
CD38 CD38 molecule 0.184662
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.184211
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.18388
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.183811
IL7R interleukin 7 receptor 0.183662
CCND3 cyclin D3 0.183612
IRF4 interferon regulatory factor 4 0.183245
CD5 CD5 molecule 0.18312
TMEM132D transmembrane protein 132D 0.183057
CD53 CD53 molecule 0.18292
SELE selectin E 0.182855
RBSN rabenosyn, RAB effector 0.182651
MNX1 motor neuron and pancreas homeobox 1 0.182542
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.182476
IGBP1 immunoglobulin (CD79A) binding protein 1 0.181728
ATR ATR serine/threonine kinase 0.181658
IL4 interleukin 4 0.1816
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.181326
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.181144
RCAN1 regulator of calcineurin 1 0.181131
HMGB2 high mobility group box 2 0.180634
JUND jun D proto-oncogene 0.180339
SMAD7 SMAD family member 7 0.180221
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.180091
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.179756
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.17966
CHEK1 checkpoint kinase 1 0.17951
FADD Fas (TNFRSF6)-associated via death domain 0.179441
ASRGL1 asparaginase like 1 0.179399
SATB1 SATB homeobox 1 0.178788
TYRO3 TYRO3 protein tyrosine kinase 0.178345
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.177288
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.175742
IFNA21 interferon, alpha 21 0.173019
IFNA17 interferon, alpha 17 0.171794
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.169809
RFC2 replication factor C (activator 1) 2, 40kDa 0.169631
RRAS related RAS viral (r-ras) oncogene homolog 0.169377
HOXB7 homeobox B7 0.168696
DAXX death-domain associated protein 0.168507
SFN stratifin 0.168344
WNT10A wingless-type MMTV integration site family, member 10A 0.168317
ASXL1 additional sex combs like transcriptional regulator 1 0.167795
HCK HCK proto-oncogene, Src family tyrosine kinase 0.167767
HDAC3 histone deacetylase 3 0.166943
IL32 interleukin 32 0.166885
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.164597
GADD45B growth arrest and DNA-damage-inducible, beta 0.164012
WNT16 wingless-type MMTV integration site family, member 16 0.163518
TYK2 tyrosine kinase 2 0.162281
SARS seryl-tRNA synthetase 0.162246
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.162211
ISG15 ISG15 ubiquitin-like modifier 0.162106
C4A complement component 4A (Rodgers blood group) 0.161461
FBXO17 F-box protein 17 0.161389
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.161172
EPHB4 EPH receptor B4 0.160989
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.160317
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.160054
TYROBP TYRO protein tyrosine kinase binding protein 0.15853
EBF1 early B-cell factor 1 0.158291
CST7 cystatin F (leukocystatin) 0.15817
PLK1 polo-like kinase 1 0.157142
PRDX6 peroxiredoxin 6 0.157057
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.156972
BTC betacellulin 0.156845
CNTN2 contactin 2 (axonal) 0.156167
TRAF3 TNF receptor-associated factor 3 0.155774
TMEM11 transmembrane protein 11 0.155512
CXCR5 chemokine (C-X-C motif) receptor 5 0.155468
CALCA calcitonin-related polypeptide alpha 0.153806
IL1R1 interleukin 1 receptor, type I 0.152352
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.151969
TICAM2 toll-like receptor adaptor molecule 2 0.150942
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.150193
PARP1 poly (ADP-ribose) polymerase 1 0.14994
EFNB2 ephrin-B2 0.149889
TGFB1 transforming growth factor, beta 1 0.149484
PDCL phosducin-like 0.149071
E2F1 E2F transcription factor 1 0.149019
SMAD6 SMAD family member 6 0.148654
CD40 CD40 molecule, TNF receptor superfamily member 5 0.148082
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.147921
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.147492
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.147331
FANCD2 Fanconi anemia, complementation group D2 0.146795
SLPI secretory leukocyte peptidase inhibitor 0.146245
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.146189
RCC1 regulator of chromosome condensation 1 0.146189
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.145694
TOP1 topoisomerase (DNA) I 0.145639
HMGA2 high mobility group AT-hook 2 0.145639
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.144795
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.14342
AICDA activation-induced cytidine deaminase 0.143245
PCSK6 proprotein convertase subtilisin/kexin type 6 0.142665
FKBP5 FK506 binding protein 5 0.142426
NONO non-POU domain containing, octamer-binding 0.140745
SDC1 syndecan 1 0.140622
TNF tumor necrosis factor 0.1405
LPO lactoperoxidase 0.140011
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.13889
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.13889
TPMT thiopurine S-methyltransferase 0.138702
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.138514
CFLAR CASP8 and FADD-like apoptosis regulator 0.138451
AK6 adenylate kinase 6 0.138137
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.138137
ANPEP alanyl (membrane) aminopeptidase 0.137879
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.137558
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.135937
PDGFA platelet-derived growth factor alpha polypeptide 0.135345
IL2RA interleukin 2 receptor, alpha 0.13528
ITK IL2-inducible T-cell kinase 0.135148
PTEN phosphatase and tensin homolog 0.135148
CD79A CD79a molecule, immunoglobulin-associated alpha 0.134815
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.134142
CENPV centromere protein V 0.133538
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.133335
H2AFX H2A histone family, member X 0.133266