prazosin-942 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the prazosin-942 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AHI1 Abelson helper integration site 1
ARTN artemin
ATG3 autophagy related 3
BBS9 Bardet-Biedl syndrome 9
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C7ORF43 chromosome 7 open reading frame 43
CACYBP calcyclin binding protein
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CRY2 cryptochrome circadian clock 2
CTAGE5 CTAGE family, member 5
CUL7 cullin 7
CYLD cylindromatosis (turban tumor syndrome)
DBT dihydrolipoamide branched chain transacylase E2
DEAF1 DEAF1 transcription factor
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DIAPH1 diaphanous-related formin 1
DIAPH2 diaphanous-related formin 2
EPHB3 EPH receptor B3
F11R F11 receptor
FAM118A family with sequence similarity 118, member A
FASTKD2 FAST kinase domains 2
FURIN furin (paired basic amino acid cleaving enzyme)
GLE1 GLE1 RNA export mediator
GMPR guanosine monophosphate reductase
GOLGA2 golgin A2
GPR143 G protein-coupled receptor 143
GREB1 growth regulation by estrogen in breast cancer 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HOXC10 homeobox C10
HYI hydroxypyruvate isomerase (putative)
IL36G interleukin 36, gamma
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
IQCK IQ motif containing K
ITGA10 integrin, alpha 10
KCNK15 potassium channel, two pore domain subfamily K, member 15
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LMF1 lipase maturation factor 1
LPIN1 lipin 1
LRRC20 leucine rich repeat containing 20
LRRC40 leucine rich repeat containing 40
MAN1C1 mannosidase, alpha, class 1C, member 1
MVD mevalonate (diphospho) decarboxylase
MVK mevalonate kinase
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPTX1 neuronal pentraxin I
ORAI2 ORAI calcium release-activated calcium modulator 2
PAQR6 progestin and adipoQ receptor family member VI
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGAP1 post-GPI attachment to proteins 1
PHKA2 phosphorylase kinase, alpha 2 (liver)
PINK1 PTEN induced putative kinase 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLL polymerase (DNA directed), lambda
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPT2 palmitoyl-protein thioesterase 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RAB3A RAB3A, member RAS oncogene family
RHOQ ras homolog family member Q
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPA4 replication protein A4, 30kDa
RYR1 ryanodine receptor 1 (skeletal)
S100A8 S100 calcium binding protein A8
SCML2 sex comb on midleg-like 2 (Drosophila)
SH2B1 SH2B adaptor protein 1
SIN3B SIN3 transcription regulator family member B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SND1-IT1 SND1 intronic transcript 1
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
SUN1 Sad1 and UNC84 domain containing 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBX19 T-box 19
TFE3 transcription factor binding to IGHM enhancer 3
TFPI2 tissue factor pathway inhibitor 2
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
TMEM53 transmembrane protein 53
TMPRSS2 transmembrane protease, serine 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRAPPC9 trafficking protein particle complex 9
TRIM25 tripartite motif containing 25
TROVE2 TROVE domain family, member 2
UBOX5 U-box domain containing 5
UBQLN4 ubiquilin 4
UPK3B uroplakin 3B
VEZT vezatin, adherens junctions transmembrane protein
WNK1 WNK lysine deficient protein kinase 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
APH1A APH1A gamma secretase subunit
ARHGAP10 Rho GTPase activating protein 10
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASB7 ankyrin repeat and SOCS box containing 7
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASNSD1 asparagine synthetase domain containing 1
BAX BCL2-associated X protein
C11ORF30 chromosome 11 open reading frame 30
C1ORF115 chromosome 1 open reading frame 115
C1ORF35 chromosome 1 open reading frame 35
CA11 carbonic anhydrase XI
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBR4 carbonyl reductase 4
CCDC6 coiled-coil domain containing 6
CCDC91 coiled-coil domain containing 91
CCNO cyclin O
CLSPN claspin
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EML4 echinoderm microtubule associated protein like 4
FADS3 fatty acid desaturase 3
FASTKD5 FAST kinase domains 5
FKBP5 FK506 binding protein 5
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR87 G protein-coupled receptor 87
GSTM2 glutathione S-transferase mu 2 (muscle)
GTF2I general transcription factor IIi
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IGFLR1 IGF-like family receptor 1
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
JADE3 jade family PHD finger 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLF3 Kruppel-like factor 3 (basic)
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LNPEP leucyl/cystinyl aminopeptidase
LYRM9 LYR motif containing 9
MAGOHB mago-nashi homolog B (Drosophila)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MTHFSD methenyltetrahydrofolate synthetase domain containing
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR1H2 nuclear receptor subfamily 1, group H, member 2
OSMR oncostatin M receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARPBP PARP1 binding protein
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PMM1 phosphomannomutase 1
PMP22 peripheral myelin protein 22
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKX protein kinase, X-linked
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
QTRT1 queuine tRNA-ribosyltransferase 1
RNF141 ring finger protein 141
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RPS17P5 ribosomal protein S17 pseudogene 5
SCYL2 SCY1-like 2 (S. cerevisiae)
SH2B3 SH2B adaptor protein 3
SIDT1 SID1 transmembrane family, member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC38A6 solute carrier family 38, member 6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNHG3 small nucleolar RNA host gene 3
SUCO SUN domain containing ossification factor
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBCCD1 TBCC domain containing 1
TMEM242 transmembrane protein 242
TMSB15A thymosin beta 15a
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRAPPC2 trafficking protein particle complex 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN5 tetraspanin 5
TUBA4A tubulin, alpha 4a
TXLNG taxilin gamma
UBXN6 UBX domain protein 6
URGCP upregulator of cell proliferation
VWA1 von Willebrand factor A domain containing 1
WDR44 WD repeat domain 44
YIPF3 Yip1 domain family, member 3
ZBTB39 zinc finger and BTB domain containing 39
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF211 zinc finger protein 211
ZNF254 zinc finger protein 254
ZNF552 zinc finger protein 552
ZNF639 zinc finger protein 639
ZNF654 zinc finger protein 654
ZNF669 zinc finger protein 669
ZNF74 zinc finger protein 74
ZNF770 zinc finger protein 770