prazosin-6315 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the prazosin-6315 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ACYP1 acylphosphatase 1, erythrocyte (common) type
AKR1C2 aldo-keto reductase family 1, member C2
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APOM apolipoprotein M
ARMCX2 armadillo repeat containing, X-linked 2
ATG10 autophagy related 10
BAHCC1 BAH domain and coiled-coil containing 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTC betacellulin
CCPG1 cell cycle progression 1
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDK2 cyclin-dependent kinase 2
CEP295 centrosomal protein 295kDa
CIB2 calcium and integrin binding family member 2
CLCN4 chloride channel, voltage-sensitive 4
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DENND2A DENN/MADD domain containing 2A
DENND2D DENN/MADD domain containing 2D
DNM3 dynamin 3
EFNA3 ephrin-A3
EHF ets homologous factor
EML2 echinoderm microtubule associated protein like 2
EPHA1 EPH receptor A1
FAM110B family with sequence similarity 110, member B
FKBP15 FK506 binding protein 15, 133kDa
FLT1 fms-related tyrosine kinase 1
FRMD4A FERM domain containing 4A
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALC galactosylceramidase
GTF2I general transcription factor IIi
HMG20B high mobility group 20B
HNMT histamine N-methyltransferase
HOOK1 hook microtubule-tethering protein 1
ICOSLG inducible T-cell co-stimulator ligand
IL15 interleukin 15
INPP5K inositol polyphosphate-5-phosphatase K
INSIG1 insulin induced gene 1
KIAA1107 KIAA1107
KLF4 Kruppel-like factor 4 (gut)
KRT38 keratin 38, type I
KYNU kynureninase
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED28 mediator complex subunit 28
MLX MLX, MAX dimerization protein
MTM1 myotubularin 1
MX1 MX dynamin-like GTPase 1
NFIB nuclear factor I/B
NFX1 nuclear transcription factor, X-box binding 1
NMT1 N-myristoyltransferase 1
NOL12 nucleolar protein 12
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
OASL 2'-5'-oligoadenylate synthetase-like
PAPOLA poly(A) polymerase alpha
PHF14 PHD finger protein 14
PHOX2B paired-like homeobox 2b
PHTF2 putative homeodomain transcription factor 2
PLCG1 phospholipase C, gamma 1
PNMA2 paraneoplastic Ma antigen 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PXDC1 PX domain containing 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB35 RAB35, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RNF32 ring finger protein 32
RRAGB Ras-related GTP binding B
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEC24D SEC24 family member D
SENP5 SUMO1/sentrin specific peptidase 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD8 SET domain containing (lysine methyltransferase) 8
SIPA1L3 signal-induced proliferation-associated 1 like 3
SNTG1 syntrophin, gamma 1
SOGA1 suppressor of glucose, autophagy associated 1
SOS2 son of sevenless homolog 2 (Drosophila)
SRRT serrate, RNA effector molecule
STEAP4 STEAP family member 4
STK3 serine/threonine kinase 3
SUGP1 SURP and G patch domain containing 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMEM53 transmembrane protein 53
TMEM8B transmembrane protein 8B
TPR translocated promoter region, nuclear basket protein
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZMYND11 zinc finger, MYND-type containing 11
ZNF276 zinc finger protein 276
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARL15 ADP-ribosylation factor-like 15
ARMC4 armadillo repeat containing 4
ARRB2 arrestin, beta 2
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C1ORF105 chromosome 1 open reading frame 105
C1ORF115 chromosome 1 open reading frame 115
C1QTNF1 C1q and tumor necrosis factor related protein 1
CAPN15 calpain 15
CCRL2 chemokine (C-C motif) receptor-like 2
CD3D CD3d molecule, delta (CD3-TCR complex)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CGREF1 cell growth regulator with EF-hand domain 1
CLDN7 claudin 7
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPEB1 cytoplasmic polyadenylation element binding protein 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DEAF1 DEAF1 transcription factor
DLL3 delta-like 3 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ELOVL4 ELOVL fatty acid elongase 4
EN1 engrailed homeobox 1
ERMP1 endoplasmic reticulum metallopeptidase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM102A family with sequence similarity 102, member A
FANCC Fanconi anemia, complementation group C
FGGY FGGY carbohydrate kinase domain containing
FMO4 flavin containing monooxygenase 4
FOXN2 forkhead box N2
FPGS folylpolyglutamate synthase
GAL3ST4 galactose-3-O-sulfotransferase 4
GALK1 galactokinase 1
GMIP GEM interacting protein
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH2L G patch domain containing 2-like
HDAC5 histone deacetylase 5
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IL17RA interleukin 17 receptor A
IRF9 interferon regulatory factor 9
KIAA0894 KIAA0894 protein
KIAA1462 KIAA1462
LAMA5 laminin, alpha 5
LINS lines homolog (Drosophila)
LOC729164 hCG1732469
LRP3 low density lipoprotein receptor-related protein 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICALL2 MICAL-like 2
MPP1 membrane protein, palmitoylated 1, 55kDa
NDE1 nudE neurodevelopment protein 1
NFS1 NFS1 cysteine desulfurase
NRSN2 neurensin 2
NSUN6 NOP2/Sun domain family, member 6
PCBP4 poly(rC) binding protein 4
PDGFRL platelet-derived growth factor receptor-like
PID1 phosphotyrosine interaction domain containing 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PRR15L proline rich 15-like
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
RNF31 ring finger protein 31
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD5 stearoyl-CoA desaturase 5
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2D2A SH2 domain containing 2A
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SOD3 superoxide dismutase 3, extracellular
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYNPO synaptopodin
THAP7 THAP domain containing 7
THBS3 thrombospondin 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VWA1 von Willebrand factor A domain containing 1
ZNF442 zinc finger protein 442
ZNF767P zinc finger family member 767, pseudogene
ZNF778 zinc finger protein 778