prasterone-6474 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the prasterone-6474 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ACTN2 actinin, alpha 2
AIF1 allograft inflammatory factor 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANGPTL2 angiopoietin-like 2
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARTN artemin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP10B ATPase, class V, type 10B
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BMP1 bone morphogenetic protein 1
C1QL1 complement component 1, q subcomponent-like 1
C2ORF27A chromosome 2 open reading frame 27A
CD84 CD84 molecule
CDK18 cyclin-dependent kinase 18
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLGN calmegin
CLIP1 CAP-GLY domain containing linker protein 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COMT catechol-O-methyltransferase
CRMP1 collapsin response mediator protein 1
CTNS cystinosin, lysosomal cystine transporter
CUL2 cullin 2
CYHR1 cysteine/histidine-rich 1
DCAF11 DDB1 and CUL4 associated factor 11
DDIT3 DNA-damage-inducible transcript 3
DGCR8 DGCR8 microprocessor complex subunit
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EGR3 early growth response 3
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FPR3 formyl peptide receptor 3
GALC galactosylceramidase
GRIP2 glutamate receptor interacting protein 2
HBS1L HBS1-like translational GTPase
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HMOX1 heme oxygenase 1
ICA1 islet cell autoantigen 1, 69kDa
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
KAZN kazrin, periplakin interacting protein
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LIN7A lin-7 homolog A (C. elegans)
LRRN3 leucine rich repeat neuronal 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA8 melanoma antigen family A8
MAL mal, T-cell differentiation protein
MANBA mannosidase, beta A, lysosomal
MAP2K2 mitogen-activated protein kinase kinase 2
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MVD mevalonate (diphospho) decarboxylase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NF1 neurofibromin 1
NKX3-2 NK3 homeobox 2
NOD1 nucleotide-binding oligomerization domain containing 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NSUN7 NOP2/Sun domain family, member 7
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
NUP98 nucleoporin 98kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PARVA parvin, alpha
PDE4DIP phosphodiesterase 4D interacting protein
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PITX1 paired-like homeodomain 1
POPDC3 popeye domain containing 3
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTHLH parathyroid hormone-like hormone
PYCRL pyrroline-5-carboxylate reductase-like
QSER1 glutamine and serine rich 1
S100A8 S100 calcium binding protein A8
SAG S-antigen; retina and pineal gland (arrestin)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD8 SET domain containing (lysine methyltransferase) 8
SGSM3 small G protein signaling modulator 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SRSF1 serine/arginine-rich splicing factor 1
SUGP1 SURP and G patch domain containing 1
TGM2 transglutaminase 2
TMEM120B transmembrane protein 120B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRADD TNFRSF1A-associated via death domain
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TTC38 tetratricopeptide repeat domain 38
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ABI3BP ABI family, member 3 (NESH) binding protein
ADAM2 ADAM metallopeptidase domain 2
ADM adrenomedullin
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARC activity-regulated cytoskeleton-associated protein
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPN asporin
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C7ORF69 chromosome 7 open reading frame 69
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCNT1 cyclin T1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CIDEC cell death-inducing DFFA-like effector c
CINP cyclin-dependent kinase 2 interacting protein
CLDN17 claudin 17
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EXD3 exonuclease 3'-5' domain containing 3
FAM155A family with sequence similarity 155, member A
FAM186A family with sequence similarity 186, member A
FBXO31 F-box protein 31
GCHFR GTP cyclohydrolase I feedback regulator
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
GRPR gastrin-releasing peptide receptor
HCFC2 host cell factor C2
HIST1H1B histone cluster 1, H1b
HIST1H1E histone cluster 1, H1e
HIST1H2BI histone cluster 1, H2bi
HIST1H3I histone cluster 1, H3i
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA1L heat shock 70kDa protein 1-like
HSPB6 heat shock protein, alpha-crystallin-related, B6
INF2 inverted formin, FH2 and WH2 domain containing
IPO8 importin 8
KIAA1456 KIAA1456
LHX1 LIM homeobox 1
LOC100131532 uncharacterized LOC100131532
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCTP1 multiple C2 domains, transmembrane 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MED31 mediator complex subunit 31
MPI mannose phosphate isomerase
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDE1 nudE neurodevelopment protein 1
NLGN1 neuroligin 1
NLRX1 NLR family member X1
NPFFR1 neuropeptide FF receptor 1
NRSN2 neurensin 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PBOV1 prostate and breast cancer overexpressed 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PPT2 palmitoyl-protein thioesterase 2
PRDM14 PR domain containing 14
PROL1 proline rich, lacrimal 1
PRSS50 protease, serine, 50
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAPSN receptor-associated protein of the synapse
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SECTM1 secreted and transmembrane 1
SFRP5 secreted frizzled-related protein 5
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC17A2 solute carrier family 17, member 2
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TIGD6 tigger transposable element derived 6
TMEM209 transmembrane protein 209
TMPRSS4 transmembrane protease, serine 4
TRABD TraB domain containing
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSPAN1 tetraspanin 1
TTLL1 tubulin tyrosine ligase-like family member 1
TUBB2B tubulin, beta 2B class IIb
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
URM1 ubiquitin related modifier 1
USP27X ubiquitin specific peptidase 27, X-linked
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF506 zinc finger protein 506