pramocaine-6054 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the pramocaine-6054 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ALOXE3 arachidonate lipoxygenase 3
ANKRD55 ankyrin repeat domain 55
APOE apolipoprotein E
AREG amphiregulin
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASB1 ankyrin repeat and SOCS box containing 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C14ORF105 chromosome 14 open reading frame 105
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CCL19 chemokine (C-C motif) ligand 19
CD200 CD200 molecule
CD70 CD70 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CTIF CBP80/20-dependent translation initiation factor
DLK1 delta-like 1 homolog (Drosophila)
DPF1 D4, zinc and double PHD fingers family 1
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
ECE1 endothelin converting enzyme 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ETV7 ets variant 7
FAM120C family with sequence similarity 120C
FGF6 fibroblast growth factor 6
FHL1 four and a half LIM domains 1
FUT2 fucosyltransferase 2 (secretor status included)
GK2 glycerol kinase 2
GPR137 G protein-coupled receptor 137
GRM8 glutamate receptor, metabotropic 8
GSAP gamma-secretase activating protein
HCRTR2 hypocretin (orexin) receptor 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HR hair growth associated
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KLHL25 kelch-like family member 25
LENEP lens epithelial protein
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIPE lipase, hormone-sensitive
LMOD1 leiomodin 1 (smooth muscle)
LRRC75B leucine rich repeat containing 75B
LYZL6 lysozyme-like 6
MLXIPL MLX interacting protein-like
MYO7A myosin VIIA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NCAN neurocan
NPPA natriuretic peptide A
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OR7E24 olfactory receptor, family 7, subfamily E, member 24
PARP11 poly (ADP-ribose) polymerase family, member 11
PCDHB13 protocadherin beta 13
POLM polymerase (DNA directed), mu
PRF1 perforin 1 (pore forming protein)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RFPL3 ret finger protein-like 3
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RTN2 reticulon 2
RXRB retinoid X receptor, beta
SAA3P serum amyloid A3 pseudogene
SCAND2P SCAN domain containing 2 pseudogene
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SH3D21 SH3 domain containing 21
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHOX2 short stature homeobox 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SIT1 signaling threshold regulating transmembrane adaptor 1
SLA Src-like-adaptor
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SNTA1 syntrophin, alpha 1
SNX1 sorting nexin 1
SRD5A3 steroid 5 alpha-reductase 3
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STAC SH3 and cysteine rich domain
STC1 stanniocalcin 1
STEAP4 STEAP family member 4
SYNDIG1 synapse differentiation inducing 1
TAPBP TAP binding protein (tapasin)
TBC1D22B TBC1 domain family, member 22B
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THRB thyroid hormone receptor, beta
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRD T cell receptor delta locus
TTC38 tetratricopeptide repeat domain 38
VNN2 vanin 2
ZC3H7B zinc finger CCCH-type containing 7B
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF259P1 zinc finger protein 259 pseudogene 1

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AOC2 amine oxidase, copper containing 2 (retina-specific)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARSB arylsulfatase B
ATG10 autophagy related 10
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C17ORF80 chromosome 17 open reading frame 80
C8ORF44 chromosome 8 open reading frame 44
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CIDEC cell death-inducing DFFA-like effector c
CLDN17 claudin 17
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTFR ciliary neurotrophic factor receptor
COPZ2 coatomer protein complex, subunit zeta 2
CPB1 carboxypeptidase B1 (tissue)
CRMP1 collapsin response mediator protein 1
CXORF56 chromosome X open reading frame 56
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCAF16 DDB1 and CUL4 associated factor 16
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTX2 deltex 2, E3 ubiquitin ligase
ELSPBP1 epididymal sperm binding protein 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM110B family with sequence similarity 110, member B
FMOD fibromodulin
GADD45G growth arrest and DNA-damage-inducible, gamma
GEMIN8 gem (nuclear organelle) associated protein 8
GPC3 glypican 3
GRPR gastrin-releasing peptide receptor
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HOXC11 homeobox C11
IFT81 intraflagellar transport 81
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM8 lysine (K)-specific demethylase 8
KLHL28 kelch-like family member 28
LINC00597 long intergenic non-protein coding RNA 597
LMX1B LIM homeobox transcription factor 1, beta
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBNL3 muscleblind-like splicing regulator 3
MSI1 musashi RNA-binding protein 1
NEUROD4 neuronal differentiation 4
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
ONECUT2 one cut homeobox 2
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA6 protocadherin alpha 6
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PODXL2 podocalyxin-like 2
POMT2 protein-O-mannosyltransferase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB30 RAB30, member RAS oncogene family
RFXAP regulatory factor X-associated protein
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF208 ring finger protein 208
RPGR retinitis pigmentosa GTPase regulator
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SLC17A2 solute carrier family 17, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMAD5 SMAD family member 5
SPINK4 serine peptidase inhibitor, Kazal type 4
SPTBN2 spectrin, beta, non-erythrocytic 2
STRA6 stimulated by retinoic acid 6
SYNC syncoilin, intermediate filament protein
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM242 transmembrane protein 242
TMPRSS4 transmembrane protease, serine 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNS2 tensin 2
TOR4A torsin family 4, member A
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
USP18 ubiquitin specific peptidase 18
WDR33 WD repeat domain 33
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX4 zinc finger homeobox 4
ZNF280D zinc finger protein 280D
ZNF324 zinc finger protein 324
ZNF362 zinc finger protein 362
ZNF428 zinc finger protein 428