pramocaine-4368 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the pramocaine-4368 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ADORA3 adenosine A3 receptor
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ART1 ADP-ribosyltransferase 1
ASMT acetylserotonin O-methyltransferase
BARX2 BARX homeobox 2
BAX BCL2-associated X protein
C17ORF53 chromosome 17 open reading frame 53
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC177 coiled-coil domain containing 177
CCDC64 coiled-coil domain containing 64
CD1C CD1c molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD47 CD47 molecule
CD53 CD53 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COL2A1 collagen, type II, alpha 1
COL9A3 collagen, type IX, alpha 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTIF CBP80/20-dependent translation initiation factor
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DUSP9 dual specificity phosphatase 9
EGF epidermal growth factor
EHD2 EH-domain containing 2
EIF3F eukaryotic translation initiation factor 3, subunit F
ETV5 ets variant 5
FBXL7 F-box and leucine-rich repeat protein 7
FGF18 fibroblast growth factor 18
FHL1 four and a half LIM domains 1
FRMD1 FERM domain containing 1
FST follistatin
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPR15 G protein-coupled receptor 15
GZMK granzyme K (granzyme 3; tryptase II)
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIC2 hypermethylated in cancer 2
HIRA histone cell cycle regulator
HN1L hematological and neurological expressed 1-like
ICOSLG inducible T-cell co-stimulator ligand
INHBA inhibin, beta A
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP1 Kv channel interacting protein 1
KRT8 keratin 8, type II
LEPR leptin receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LIMK1 LIM domain kinase 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMNB1 lamin B1
LOC79999 uncharacterized LOC79999
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTB4R leukotriene B4 receptor
LY9 lymphocyte antigen 9
MAN2A2 mannosidase, alpha, class 2A, member 2
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLXIP MLX interacting protein
MOB3B MOB kinase activator 3B
MST1 macrophage stimulating 1
MXD4 MAX dimerization protein 4
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OVOL1 ovo-like zinc finger 1
PAX3 paired box 3
PCDHGA8 protocadherin gamma subfamily A, 8
PCSK6 proprotein convertase subtilisin/kexin type 6
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCB protein kinase C, beta
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB6B RAB6B, member RAS oncogene family
RASAL2 RAS protein activator like 2
RIMS1 regulating synaptic membrane exocytosis 1
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1
RTEL1 regulator of telomere elongation helicase 1
S100B S100 calcium binding protein B
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SSX3 synovial sarcoma, X breakpoint 3
SYN2 synapsin II
TAGLN3 transgelin 3
TP63 tumor protein p63
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRBC1 T cell receptor beta constant 1
TRPM3 transient receptor potential cation channel, subfamily M, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP2 ubiquitin specific peptidase 2
ZC3H13 zinc finger CCCH-type containing 13

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKAP12 A kinase (PRKA) anchor protein 12
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
ARHGAP4 Rho GTPase activating protein 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBS10 Bardet-Biedl syndrome 10
BLNK B-cell linker
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C8ORF60 chromosome 8 open reading frame 60
CASC1 cancer susceptibility candidate 1
CCDC121 coiled-coil domain containing 121
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CGA glycoprotein hormones, alpha polypeptide
CHML choroideremia-like (Rab escort protein 2)
CLGN calmegin
CLSTN2 calsyntenin 2
CNTFR ciliary neurotrophic factor receptor
CSF1R colony stimulating factor 1 receptor
CSTA cystatin A (stefin A)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNM3 dynamin 3
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
ERCC2 excision repair cross-complementation group 2
FGF13 fibroblast growth factor 13
FGF23 fibroblast growth factor 23
FKRP fukutin related protein
FSTL1 follistatin-like 1
GALK1 galactokinase 1
GAMT guanidinoacetate N-methyltransferase
GAS2 growth arrest-specific 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRAMD1C GRAM domain containing 1C
GSTA4 glutathione S-transferase alpha 4
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXB2 homeobox B2
HOXC10 homeobox C10
IFI27 interferon, alpha-inducible protein 27
IPO8 importin 8
IQCC IQ motif containing C
IQSEC2 IQ motif and Sec7 domain 2
IRF1 interferon regulatory factor 1
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA1107 KIAA1107
KIF13A kinesin family member 13A
KRT24 keratin 24, type I
L2HGDH L-2-hydroxyglutarate dehydrogenase
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100286895 cell division cycle 27 homolog pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
NPIPB15 nuclear pore complex interacting protein family, member B15
NPIPB3 nuclear pore complex interacting protein family, member B3
NXPE3 neurexophilin and PC-esterase domain family, member 3
ONECUT2 one cut homeobox 2
PCDHB8 protocadherin beta 8
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PGM1 phosphoglucomutase 1
PICK1 protein interacting with PRKCA 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNB3 plexin B3
PMCH pro-melanin-concentrating hormone
PODNL1 podocan-like 1
POLM polymerase (DNA directed), mu
PRR4 proline rich 4 (lacrimal)
RFXAP regulatory factor X-associated protein
RNASEH2B ribonuclease H2, subunit B
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
RUSC2 RUN and SH3 domain containing 2
S100A7 S100 calcium binding protein A7
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STIM1 stromal interaction molecule 1
STON1 stonin 1
STX1A syntaxin 1A (brain)
TBC1D2 TBC1 domain family, member 2
TMEM242 transmembrane protein 242
TMSB15B thymosin beta 15B
TTC33 tetratricopeptide repeat domain 33
VIM vimentin
WFDC2 WAP four-disulfide core domain 2
ZNF35 zinc finger protein 35
ZNF37BP zinc finger protein 37B, pseudogene
ZSWIM1 zinc finger, SWIM-type containing 1