polycystic ovary syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_11612)
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Genes

237 genes co-occuring with the disease polycystic ovary syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SHBG sex hormone-binding globulin 2.91954
INS insulin 2.77145
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.538
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.53037
AMH anti-Mullerian hormone 2.17653
LEP leptin 1.83364
FBN3 fibrillin 3 1.72958
POMC proopiomelanocortin 1.70269
PRL prolactin 1.69815
FSHR follicle stimulating hormone receptor 1.66735
INSR insulin receptor 1.65879
IGF1 insulin-like growth factor 1 (somatomedin C) 1.6498
IGFBP1 insulin-like growth factor binding protein 1 1.62112
DENND1A DENN/MADD domain containing 1A 1.60681
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.5818
CRP C-reactive protein, pentraxin-related 1.43683
IRS1 insulin receptor substrate 1 1.43376
FST follistatin 1.38385
RETN resistin 1.30314
NAMPT nicotinamide phosphoribosyltransferase 1.29571
AR androgen receptor 1.27301
LHCGR luteinizing hormone/choriogonadotropin receptor 1.26516
GHRL ghrelin/obestatin prepropeptide 1.26386
GDF9 growth differentiation factor 9 1.25863
CAPN10 calpain 10 1.24863
BMP15 bone morphogenetic protein 15 1.23994
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.19273
STAR steroidogenic acute regulatory protein 1.1841
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.1605
PPARG peroxisome proliferator-activated receptor gamma 1.13036
RBP4 retinol binding protein 4, plasma 1.11057
THADA thyroid adenoma associated 1.10846
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.09755
IRS2 insulin receptor substrate 2 1.07782
ITLN1 intelectin 1 (galactofuranose binding) 1.06312
IGFBP3 insulin-like growth factor binding protein 3 1.0442
FTO fat mass and obesity associated 1.04377
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.01765
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.00837
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.0071
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 1.00541
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.992752
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 0.908142
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 0.906909
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.826589
COG2 component of oligomeric golgi complex 2 0.823308
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.820026
APOA1 apolipoprotein A-I 0.806077
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.801564
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.799513
GPR83 G protein-coupled receptor 83 0.785574
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.779841
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.771661
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.761047
LIPE lipase, hormone-sensitive 0.760231
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.756971
POTED POTE ankyrin domain family, member D 0.751271
POTEB POTE ankyrin domain family, member B 0.751271
MIR3118-1 microRNA 3118-1 0.751271
PLG plasminogen 0.743547
PON1 paraoxonase 1 0.73746
PEA15 phosphoprotein enriched in astrocytes 15 0.731381
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.728547
IL6 interleukin 6 0.716828
GHRH growth hormone releasing hormone 0.703134
GNRHR gonadotropin-releasing hormone receptor 0.70233
ESR1 estrogen receptor 1 0.70233
ADIPOR1 adiponectin receptor 1 0.696306
LEPR leptin receptor 0.693098
APOB apolipoprotein B 0.685491
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.685091
ADIPOR2 adiponectin receptor 2 0.672324
GATA6 GATA binding protein 6 0.65288
POR P450 (cytochrome) oxidoreductase 0.648138
TRH thyrotropin-releasing hormone 0.644586
FEM1B fem-1 homolog b (C. elegans) 0.641827
INHA inhibin, alpha 0.639463
NGF nerve growth factor (beta polypeptide) 0.619442
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.609276
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.60303
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.591337
CRH corticotropin releasing hormone 0.588222
INSL3 insulin-like 3 (Leydig cell) 0.583941
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.580439
TNF tumor necrosis factor 0.576161
DRAM2 DNA-damage regulated autophagy modulator 2 0.569163
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.563335
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 0.562946
FEM1C fem-1 homolog c (C. elegans) 0.556344
FSHB follicle stimulating hormone, beta polypeptide 0.550134
F10 coagulation factor X 0.546644
IGF2 insulin-like growth factor 2 0.54393
NPY neuropeptide Y 0.542767
KISS1 KiSS-1 metastasis-suppressor 0.538118
PSG1 pregnancy specific beta-1-glycoprotein 1 0.536957
LMNA lamin A/C 0.534635
LHB luteinizing hormone beta polypeptide 0.526904
IGSF1 immunoglobulin superfamily, member 1 0.51919
ECI1 enoyl-CoA delta isomerase 1 0.51842
APMAP adipocyte plasma membrane associated protein 0.51188
PAEP progestagen-associated endometrial protein 0.508424
FABP4 fatty acid binding protein 4, adipocyte 0.503058
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.49274
SST somatostatin 0.472604
SORBS1 sorbin and SH3 domain containing 1 0.471846
FGD1 FYVE, RhoGEF and PH domain containing 1 0.469197
NSL1 NSL1, MIS12 kinetochore complex component 0.460883
ESR2 estrogen receptor 2 (ER beta) 0.449571
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 0.448064
AMHR2 anti-Mullerian hormone receptor, type II 0.445052
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.42589
REN renin 0.424389
LCN2 lipocalin 2 0.42214
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.419142
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.416896
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.410535
TBC1D4 TBC1 domain family, member 4 0.408666
CYC1 cytochrome c-1 0.397471
NPM2 nucleophosmin/nucleoplasmin 2 0.394491
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.392257
TM4SF4 transmembrane 4 L six family member 4 0.390769
IGFBP4 insulin-like growth factor binding protein 4 0.386679
TCHH trichohyalin 0.383337
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.38111
MMP2 matrix metallopeptidase 2 0.379256
NEGR1 neuronal growth regulator 1 0.378143
PPARA peroxisome proliferator-activated receptor alpha 0.369997
FOXJ2 forkhead box J2 0.360764
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.360395
ZNF92 zinc finger protein 92 0.351555
CAPN5 calpain 5 0.351555
VCAM1 vascular cell adhesion molecule 1 0.350084
ADRB3 adrenoceptor beta 3 0.349717
LPA lipoprotein, Lp(a) 0.349717
AKR1C1 aldo-keto reductase family 1, member C1 0.348614
ALB albumin 0.348246
IL18 interleukin 18 0.347879
HSPE1 heat shock 10kDa protein 1 0.344574
PADI6 peptidyl arginine deiminase, type VI 0.344207
CCR10 chemokine (C-C motif) receptor 10 0.34384
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.343106
PNPLA2 patatin-like phospholipase domain containing 2 0.341272
CNGA1 cyclic nucleotide gated channel alpha 1 0.338707
DEGS2 delta(4)-desaturase, sphingolipid 2 0.337975
GAB1 GRB2-associated binding protein 1 0.336876
CPB2 carboxypeptidase B2 (plasma) 0.33651
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.332487
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.330295
PGR progesterone receptor 0.3292
SIGLEC11 sialic acid binding Ig-like lectin 11 0.32373
EDN1 endothelin 1 0.322637
KISS1R KISS1 receptor 0.313189
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.312464
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.311014
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.294772
STS steroid sulfatase (microsomal), isozyme S 0.294413
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.291898
FGF22 fibroblast growth factor 22 0.290103
CYTL1 cytokine-like 1 0.289744
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.289386
GCG glucagon 0.289027
IGF1R insulin-like growth factor 1 receptor 0.287593
BMP6 bone morphogenetic protein 6 0.277227
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.276158
BMP8A bone morphogenetic protein 8a 0.273308
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.267622
TRO trophinin 0.266558
SLC2A4RG SLC2A4 regulator 0.265849
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.263722
PROK1 prokineticin 1 0.257358
HOXA1 homeobox A1 0.256299
MAPK3 mitogen-activated protein kinase 3 0.255241
CCL2 chemokine (C-C motif) ligand 2 0.251718
SP6 Sp6 transcription factor 0.245396
MMP9 matrix metallopeptidase 9 0.245046
SOD2 superoxide dismutase 2, mitochondrial 0.244345
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.240847
AQP9 aquaporin 9 0.238403
MAK male germ cell-associated kinase 0.238054
GSK3B glycogen synthase kinase 3 beta 0.23666
AFM afamin 0.233878
INSIG1 insulin induced gene 1 0.232489
MGP matrix Gla protein 0.228333
LTBP1 latent transforming growth factor beta binding protein 1 0.226607
COMT catechol-O-methyltransferase 0.222822
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.222136
MC4R melanocortin 4 receptor 0.221108
C9ORF3 chromosome 9 open reading frame 3 0.218715
ADRA1B adrenoceptor alpha 1B 0.214297
MEP1A meprin A, alpha (PABA peptide hydrolase) 0.214297
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.212271
MMP26 matrix metallopeptidase 26 0.210253
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 0.209248
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.207912
HIF3A hypoxia inducible factor 3, alpha subunit 0.206913
SORBS2 sorbin and SH3 domain containing 2 0.206913
MEGF6 multiple EGF-like-domains 6 0.206248
HAND2 heart and neural crest derivatives expressed 2 0.205916
PDE8A phosphodiesterase 8A 0.204593
ICAM1 intercellular adhesion molecule 1 0.202618
MEF2A myocyte enhancer factor 2A 0.20229
RAB5B RAB5B, member RAS oncogene family 0.201308
SERBP1 SERPINE1 mRNA binding protein 1 0.200656
VWF von Willebrand factor 0.200331
F2 coagulation factor II (thrombin) 0.199681
HAS2 hyaluronan synthase 2 0.197099
GPX5 glutathione peroxidase 5 0.194548
SFPQ splicing factor proline/glutamine-rich 0.193915
TIMP1 TIMP metallopeptidase inhibitor 1 0.192031
GPX4 glutathione peroxidase 4 0.192031
SEC16B SEC16 homolog B (S. cerevisiae) 0.183248
KCTD15 potassium channel tetramerization domain containing 15 0.181798
GPX1 glutathione peroxidase 1 0.179802
PLAT plasminogen activator, tissue 0.17896
LTBP3 latent transforming growth factor beta binding protein 3 0.178126
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 0.177576
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.174617
ENHO energy homeostasis associated 0.174617
CMKLR1 chemerin chemokine-like receptor 1 0.174093
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.173571
NPS neuropeptide S 0.170054
F5 coagulation factor V (proaccelerin, labile factor) 0.168148
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.165874
KAT2A K(lysine) acetyltransferase 2A 0.165435
PYY peptide YY 0.162908
GPR4 G protein-coupled receptor 4 0.162306
SUOX sulfite oxidase 0.162306
PGRMC1 progesterone receptor membrane component 1 0.162109
AHSG alpha-2-HS-glycoprotein 0.161912
LPIN1 lipin 1 0.160948
DUSP12 dual specificity phosphatase 12 0.160948
MTNR1B melatonin receptor 1B 0.160761
AREG amphiregulin 0.160761
GAN gigaxonin 0.15948
FGF21 fibroblast growth factor 21 0.158605
RAB10 RAB10, member RAS oncogene family 0.157929
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.157602