polycystic kidney disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An autosomal dominant disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium. (Human Disease Ontology, DOID_898)
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Genes

336 genes co-occuring with the disease polycystic kidney disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PKD1 polycystic kidney disease 1 (autosomal dominant) 4.0405
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 3.52953
PKD2 polycystic kidney disease 2 (autosomal dominant) 3.25282
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 2.78678
PKD2L1 polycystic kidney disease 2-like 1 1.99595
PRKCSH protein kinase C substrate 80K-H 1.85958
PKD1L3 polycystic kidney disease 1-like 3 1.75596
IFT88 intraflagellar transport 88 1.6606
NEK8 NIMA-related kinase 8 1.635
PKDREJ polycystin (PKD) family receptor for egg jelly 1.62918
TSC2 tuberous sclerosis 2 1.61307
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.58046
NEK1 NIMA-related kinase 1 1.54142
PGP phosphoglycolate phosphatase 1.49657
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 1.49657
NEK9 NIMA-related kinase 9 1.45441
OFD1 oral-facial-digital syndrome 1 1.44694
PRKD3 protein kinase D3 1.39389
KIF3A kinesin family member 3A 1.37469
EXOC5 exocyst complex component 5 1.35899
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.32323
SEC63 SEC63 homolog (S. cerevisiae) 1.32236
INVS inversin 1.29309
PKD1L1 polycystic kidney disease 1 like 1 1.26996
PKD2L2 polycystic kidney disease 2-like 2 1.24993
AVPR2 arginine vasopressin receptor 2 1.21868
TMEM67 transmembrane protein 67 1.21652
NPHP3 nephronophthisis 3 (adolescent) 1.19791
AQP2 aquaporin 2 (collecting duct) 1.15198
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 1.11603
ACE angiotensin I converting enzyme 1.11519
NPHP1 nephronophthisis 1 (juvenile) 1.10678
HNF1B HNF1 homeobox B 1.06354
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.02735
BICC1 BicC family RNA binding protein 1 1.02355
RPL3L ribosomal protein L3-like 0.993596
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.993596
TRAM2 translocation associated membrane protein 2 0.990644
DNAH8 dynein, axonemal, heavy chain 8 0.980531
ARL13A ADP-ribosylation factor-like 13A 0.97128
SAP30L SAP30-like 0.97128
MKRN1 makorin ring finger protein 1 0.965405
REN renin 0.960797
CCDC91 coiled-coil domain containing 91 0.957868
TPSG1 tryptase gamma 1 0.954525
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.932484
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.932484
IFT20 intraflagellar transport 20 0.918436
RAB26 RAB26, member RAS oncogene family 0.914727
CYS1 cystin 1 0.908142
KIF12 kinesin family member 12 0.889668
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 0.878605
FJX1 four jointed box 1 (Drosophila) 0.874509
PCNA proliferating cell nuclear antigen 0.861409
TMEM216 transmembrane protein 216 0.853221
EXOC3 exocyst complex component 3 0.846669
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.834788
TMEM2 transmembrane protein 2 0.833968
CSN1S1 casein alpha s1 0.833558
ALB albumin 0.813052
WWTR1 WW domain containing transcription regulator 1 0.812232
PPP1R7 protein phosphatase 1, regulatory subunit 7 0.791721
TSSC4 tumor suppressing subtransferable candidate 4 0.789672
LIG3 ligase III, DNA, ATP-dependent 0.787623
APOPT1 apoptogenic 1, mitochondrial 0.785984
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 0.778613
IFT52 intraflagellar transport 52 0.778613
CEP70 centrosomal protein 70kDa 0.763086
RAB28 RAB28, member RAS oncogene family 0.762678
ADCY2 adenylate cyclase 2 (brain) 0.758601
TMEM27 transmembrane protein 27 0.752492
MXI1 MAX interactor 1, dimerization protein 0.745985
SST somatostatin 0.745578
UMOD uromodulin 0.737865
PRKX protein kinase, X-linked 0.736243
ADGRE2 adhesion G protein-coupled receptor E2 0.728952
CEP97 centrosomal protein 97kDa 0.727333
MKS1 Meckel syndrome, type 1 0.72612
RAB8A RAB8A, member RAS oncogene family 0.722077
DCTN5 dynactin 5 (p25) 0.714811
EGFR epidermal growth factor receptor 0.711183
TMEM231 transmembrane protein 231 0.709975
HAVCR1 hepatitis A virus cellular receptor 1 0.708767
KIF3B kinesin family member 3B 0.707961
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.705949
HAGH hydroxyacylglutathione hydrolase 0.705144
TBC1D30 TBC1 domain family, member 30 0.698715
NPHP4 nephronophthisis 4 0.69751
GLIS2 GLIS family zinc finger 2 0.693098
RGS7 regulator of G-protein signaling 7 0.668345
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.66755
HRAS Harvey rat sarcoma viral oncogene homolog 0.660008
BTK Bruton agammaglobulinemia tyrosine kinase 0.65763
C1RL complement component 1, r subcomponent-like 0.652484
PAX2 paired box 2 0.652089
WDR19 WD repeat domain 19 0.650113
FN1 fibronectin 1 0.647743
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.642221
CASKIN1 CASK interacting protein 1 0.635921
ARL13B ADP-ribosylation factor-like 13B 0.63042
ARF4 ADP-ribosylation factor 4 0.62728
AGXT alanine-glyoxylate aminotransferase 0.624535
FBXL20 F-box and leucine-rich repeat protein 20 0.6214
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.617486
NUBP1 nucleotide binding protein 1 0.617486
IFT81 intraflagellar transport 81 0.616703
LCN2 lipocalin 2 0.608494
ATP11A ATPase, class VI, type 11A 0.607714
DPT dermatopontin 0.604981
NEK7 NIMA-related kinase 7 0.604981
NOS3 nitric oxide synthase 3 (endothelial cell) 0.60303
CUX1 cut-like homeobox 1 0.60264
ANK1 ankyrin 1, erythrocytic 0.59991
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.598351
MCHR2 melanin-concentrating hormone receptor 2 0.595233
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.592506
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.592116
TAS2R14 taste receptor, type 2, member 14 0.592116
AVP arginine vasopressin 0.591727
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G 0.587444
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.583941
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.580828
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.572273
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.571495
GPSM1 G-protein signaling modulator 1 0.553239
SPATA4 spermatogenesis associated 4 0.549359
SYTL2 synaptotagmin-like 2 0.540442
NTN3 netrin 3 0.539667
MECR mitochondrial trans-2-enoyl-CoA reductase 0.537344
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 0.53657
LAMA5 laminin, alpha 5 0.535409
POC1B POC1 centriolar protein B 0.533475
FZD3 frizzled class receptor 3 0.524588
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.518034
IFT172 intraflagellar transport 172 0.517265
FGF23 fibroblast growth factor 23 0.508808
B9D1 B9 protein domain 1 0.508041
MEP1B meprin A, beta 0.499997
DIAPH1 diaphanous-related formin 1 0.493885
TPK1 thiamin pyrophosphokinase 1 0.490072
SSTR5 somatostatin receptor 5 0.487788
BAIAP3 BAI1-associated protein 3 0.487027
NID1 nidogen 1 0.483985
PAQR7 progestin and adipoQ receptor family member VII 0.483224
ZHX2 zinc fingers and homeoboxes 2 0.480566
GPNMB glycoprotein (transmembrane) nmb 0.480566
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 0.479047
UGCG UDP-glucose ceramide glucosyltransferase 0.478668
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.477909
CEP164 centrosomal protein 164kDa 0.476393
IFT140 intraflagellar transport 140 0.473361
TGFB1 transforming growth factor, beta 1 0.471846
FREM3 FRAS1 related extracellular matrix 3 0.469197
PACS2 phosphofurin acidic cluster sorting protein 2 0.468819
SEC24D SEC24 family member D 0.465794
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.463905
PTH parathyroid hormone 0.457864
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) 0.456355
DNAAF1 dynein, axonemal, assembly factor 1 0.454093
GLIS3 GLIS family zinc finger 3 0.439786
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.43753
MTMR6 myotubularin related protein 6 0.433397
GLIS1 GLIS family zinc finger 1 0.428891
TBK1 TANK-binding kinase 1 0.428891
GLOD4 glyoxalase domain containing 4 0.428891
SRCAP Snf2-related CREBBP activator protein 0.42589
TBC1D7 TBC1 domain family, member 7 0.424765
PXN paxillin 0.42214
NPPA natriuretic peptide A 0.421765
ODF2 outer dense fiber of sperm tails 2 0.417644
PACS1 phosphofurin acidic cluster sorting protein 1 0.413901
MEP1A meprin A, alpha (PABA peptide hydrolase) 0.406798
LRRC6 leucine rich repeat containing 6 0.398216
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 0.397098
ARL6 ADP-ribosylation factor-like 6 0.395608
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 0.394863
TNRC6A trinucleotide repeat containing 6A 0.391513
NOTCH2 notch 2 0.391141
NOTCH2NL notch 2 N-terminal like 0.388538
STX5 syntaxin 5 0.387051
AQP1 aquaporin 1 (Colton blood group) 0.387051
CDC23 cell division cycle 23 0.385565
PARD6A par-6 family cell polarity regulator alpha 0.383337
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.382223
TTC21B tetratricopeptide repeat domain 21B 0.380739
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 0.378885
CDC25A cell division cycle 25A 0.378885
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.377773
LIN7C lin-7 homolog C (C. elegans) 0.37592
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.373328
ADCY6 adenylate cyclase 6 0.372217
CDH8 cadherin 8, type 2 0.358183
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 0.357446
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.348981
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.347144
LRP2 low density lipoprotein receptor-related protein 2 0.34384
CDC73 cell division cycle 73 0.342739
TNS3 tensin 3 0.341639
TREH trehalase (brush-border membrane glycoprotein) 0.341639
LEFTY2 left-right determination factor 2 0.339806
MCOLN1 mucolipin 1 0.334315
CTRB1 chymotrypsinogen B1 0.331025
IGF1 insulin-like growth factor 1 (somatomedin C) 0.3292
AREG amphiregulin 0.3292
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.328469
AQP11 aquaporin 11 0.32774
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 0.327375
FOS FBJ murine osteosarcoma viral oncogene homolog 0.327375
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.326281
PLCB2 phospholipase C, beta 2 0.324823
TF transferrin 0.324094
DNAI2 dynein, axonemal, intermediate chain 2 0.32373
KCNK10 potassium channel, two pore domain subfamily K, member 10 0.321181
ETNK1 ethanolamine kinase 1 0.321181
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.319363
DICER1 dicer 1, ribonuclease type III 0.317545
JADE1 jade family PHD finger 1 0.315003
CABIN1 calcineurin binding protein 1 0.313552
ZNF165 zinc finger protein 165 0.313552
HBA2 hemoglobin, alpha 2 0.312464
SIAH1 siah E3 ubiquitin protein ligase 1 0.311377
CRP C-reactive protein, pentraxin-related 0.30631
FRY furry homolog (Drosophila) 0.305587
CPD carboxypeptidase D 0.304142
HOXB7 homeobox B7 0.302698
ANO6 anoctamin 6 0.301254
HDAC6 histone deacetylase 6 0.300533
MAPK3 mitogen-activated protein kinase 3 0.300173
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.299812
SMO smoothened, frizzled class receptor 0.298371
NEK6 NIMA-related kinase 6 0.298371
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.294053
PDE4C phosphodiesterase 4C, cAMP-specific 0.292616
FBLN1 fibulin 1 0.29118
HBA1 hemoglobin, alpha 1 0.288668
P4HB prolyl 4-hydroxylase, beta polypeptide 0.28831
TNS2 tensin 2 0.282582
ITGA8 integrin, alpha 8 0.280082
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.278654
CCNF cyclin F 0.274376
CTSH cathepsin H 0.272597
SIGLEC14 sialic acid binding Ig-like lectin 14 0.269753
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.268687
TNS4 tensin 4 0.267622
KDM2B lysine (K)-specific demethylase 2B 0.265849
HAX1 HCLS1 associated protein X-1 0.259477
FMN1 formin 1 0.259124
INS insulin 0.257711
TSC1 tuberous sclerosis 1 0.257358
PRKD1 protein kinase D1 0.253127
FBN1 fibrillin 1 0.251366
ONECUT1 one cut homeobox 1 0.251366
CKAP4 cytoskeleton-associated protein 4 0.247501
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.246799
HBEGF heparin-binding EGF-like growth factor 0.246448
INADL InaD-like (Drosophila) 0.245396
BBS4 Bardet-Biedl syndrome 4 0.244696
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.241196
FTL ferritin, light polypeptide 0.23945
FTH1 ferritin, heavy polypeptide 1 0.239101
XYLT2 xylosyltransferase II 0.236312
CST3 cystatin C 0.23492
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.232836
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.232489
HIST1H4F histone cluster 1, H4f 0.232142
HIST1H4K histone cluster 1, H4k 0.232142
HIST1H4H histone cluster 1, H4h 0.232142
HIST1H4D histone cluster 1, H4d 0.232142
HIST1H4E histone cluster 1, H4e 0.232142
HIST1H4I histone cluster 1, H4i 0.232142
HIST1H4A histone cluster 1, H4a 0.232142
HIST2H4B histone cluster 2, H4b 0.232142
HIST1H4B histone cluster 1, H4b 0.232142
HIST1H4C histone cluster 1, H4c 0.232142
HIST1H4J histone cluster 1, H4j 0.232142
HIST2H4A histone cluster 2, H4a 0.231448
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.230755
HIST4H4 histone cluster 4, H4 0.229716
HIST1H4L histone cluster 1, H4l 0.229716
GCDH glutaryl-CoA dehydrogenase 0.228333
CAMLG calcium modulating ligand 0.227988
AKAP1 A kinase (PRKA) anchor protein 1 0.227642
FREM2 FRAS1 related extracellular matrix protein 2 0.226952
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.226262
CEMIP cell migration inducing protein, hyaluronan binding 0.224884
SNAPIN SNAP-associated protein 0.22454
CCL2 chemokine (C-C motif) ligand 2 0.224196
C9 complement component 9 0.223165
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.217693
CHKB choline kinase beta 0.215314
RHEB Ras homolog enriched in brain 0.213621
LGALS4 lectin, galactoside-binding, soluble, 4 0.211934
BEST3 bestrophin 3 0.209918
ARL3 ADP-ribosylation factor-like 3 0.209918
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.209583
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.209248
CASR calcium-sensing receptor 0.208579
ALPPL2 alkaline phosphatase, placental-like 2 0.202946
ALPP alkaline phosphatase, placental 0.202618
SFRP4 secreted frizzled-related protein 4 0.201962
ALPL alkaline phosphatase, liver/bone/kidney 0.201962
CDC42 cell division cycle 42 0.200006
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.199681
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.198064
EDNRA endothelin receptor type A 0.197099
CC2D2A coiled-coil and C2 domain containing 2A 0.196779
EDN1 endothelin 1 0.195501
ZSCAN1 zinc finger and SCAN domain containing 1 0.195183
NEXN nexilin (F actin binding protein) 0.191097
FLNA filamin A, alpha 0.189244
CREB1 cAMP responsive element binding protein 1 0.188022
HDAC9 histone deacetylase 9 0.187719
CTGF connective tissue growth factor 0.180652
BRD7 bromodomain containing 7 0.179802
TJP1 tight junction protein 1 0.178682
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.177851
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.177301
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.175411
PGF placental growth factor 0.174881
B2M beta-2-microglobulin 0.171785
FLT1 fms-related tyrosine kinase 1 0.170789
ADD1 adducin 1 (alpha) 0.16933
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.168617
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.167452
ACTN2 actinin, alpha 2 0.166319
C3 complement component 3 0.165435
ACTG1 actin gamma 1 0.164149
RAD9A RAD9 homolog A (S. pombe) 0.163111
EMP1 epithelial membrane protein 1 0.162908
WNT9B wingless-type MMTV integration site family, member 9B 0.162109
FRAS1 Fraser extracellular matrix complex subunit 1 0.161331
SPATA21 spermatogenesis associated 21 0.160761
TTC8 tetratricopeptide repeat domain 8 0.15948
CLU clusterin 0.158434
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.158097
KIAA1109 KIAA1109 0.157765