podocyte foot process effacement Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description a podocyte reaction to injury or damage characterized by flattening of foot processes due to gradual simplification of the interdigitating foot process; the whole podocyte looks flat due to retraction, widening, and shortening of the processes of each podocyte while the frequency of filtration slits is reduced, giving the appearance of a continuous cytoplasmic sheet covering the glomerular basement membrane (Mammalian Phenotype Ontology, MP_0008140)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008140
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Genes

23 gene mutations causing the podocyte foot process effacement phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTN4 actinin, alpha 4
AMPD2 adenosine monophosphate deaminase 2
BCL2 B-cell CLL/lymphoma 2
CD151 CD151 molecule (Raph blood group)
COL18A1 collagen, type XVIII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A5 collagen, type IV, alpha 5
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
FAS Fas cell surface death receptor
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRM1 glutamate receptor, metabotropic 1
GSTK1 glutathione S-transferase kappa 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
ITGA1 integrin, alpha 1
MPV17 MpV17 mitochondrial inner membrane protein
MYH9 myosin, heavy chain 9, non-muscle
MYO1E myosin IE
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
WT1 Wilms tumor 1