pneumonia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. (Experimental Factor Ontology, EFO_0003106)
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Genes

115 genes co-occuring with the biological term pneumonia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADM adrenomedullin
AGER advanced glycosylation end product-specific receptor
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AVP arginine vasopressin
AXL AXL receptor tyrosine kinase
BDNF brain-derived neurotrophic factor
BPI bactericidal/permeability-increasing protein
CALCA calcitonin-related polypeptide alpha
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCL16 chemokine (C-C motif) ligand 16
CCL17 chemokine (C-C motif) ligand 17
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD14 CD14 molecule
CD276 CD276 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
CMA1 chymase 1, mast cell
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
CYBB cytochrome b-245, beta polypeptide
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DEFB103B defensin, beta 103B
DEFB4A defensin, beta 4A
ELANE elastase, neutrophil expressed
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GSTM1 glutathione S-transferase mu 1
HBM hemoglobin, mu
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IRAK3 interleukin-1 receptor-associated kinase 3
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KRT10 keratin 10, type I
LCN2 lipocalin 2
LGALS9 lectin, galactoside-binding, soluble, 9
LTA lymphotoxin alpha
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NLRP3 NLR family, pyrin domain containing 3
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NTF3 neurotrophin 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
POSTN periostin, osteoblast specific factor
PRKCA protein kinase C, alpha
PTAFR platelet-activating factor receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA2 surfactant protein A2
SFTPD surfactant protein D
SLPI secretory leukocyte peptidase inhibitor
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
STX2 syntaxin 2
TAC1 tachykinin, precursor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR3 toll-like receptor 3
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TNC tenascin C
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNT2 troponin T type 2 (cardiac)
TREM1 triggering receptor expressed on myeloid cells 1
TXN thioredoxin
VEGFA vascular endothelial growth factor A