pleural disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. (Human Disease Ontology, DOID_1532)
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Genes

300 genes co-occuring with the disease pleural disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FLCN folliculin 2.58223
ADA adenosine deaminase 1.77767
KNG1 kininogen 1 1.5194
FNIP2 folliculin interacting protein 2 1.36771
FNIP1 folliculin interacting protein 1 1.35202
MPO myeloperoxidase 1.20613
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.20483
PPCS phosphopantothenoylcysteine synthetase 1.16179
IL1B interleukin 1, beta 1.15581
ALB albumin 1.09629
ALOX5 arachidonate 5-lipoxygenase 1.05513
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.04798
KIAA0101 KIAA0101 1.03872
TNF tumor necrosis factor 1.02777
TEF thyrotrophic embryonic factor 0.99233
CTSC cathepsin C 0.97086
PDLIM7 PDZ and LIM domain 7 (enigma) 0.942858
MSLN mesothelin 0.93
COL3A1 collagen, type III, alpha 1 0.907731
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.861409
TADA1 transcriptional adaptor 1 0.848716
WNT10A wingless-type MMTV integration site family, member 10A 0.846259
CD4 CD4 molecule 0.838476
SCAND1 SCAN domain containing 1 0.820026
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.752898
PTGES prostaglandin E synthase 0.744766
ICAM1 intercellular adhesion molecule 1 0.743954
PLA2G1B phospholipase A2, group IB (pancreas) 0.727333
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.716021
TSC2 tuberous sclerosis 2 0.712796
CRP C-reactive protein, pentraxin-related 0.711587
IL2 interleukin 2 0.708364
BET1 Bet1 golgi vesicular membrane trafficking protein 0.706351
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 0.705949
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.699919
FLNC filamin C, gamma 0.666358
MEFV Mediterranean fever 0.656837
IGH immunoglobulin heavy locus 0.65565
CXCL8 chemokine (C-X-C motif) ligand 8 0.650903
ARR3 arrestin 3, retinal (X-arrestin) 0.644586
APLF aprataxin and PNKP like factor 0.629635
LYZ lysozyme 0.621792
PTBP3 polypyrimidine tract binding protein 3 0.620617
F2RL3 coagulation factor II (thrombin) receptor-like 3 0.606152
FXYD1 FXYD domain containing ion transport regulator 1 0.60069
ENO2 enolase 2 (gamma, neuronal) 0.598351
PGRMC1 progesterone receptor membrane component 1 0.597181
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.586665
POMC proopiomelanocortin 0.583552
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.581217
TAC1 tachykinin, precursor 1 0.580828
PGP phosphoglycolate phosphatase 0.58005
PLA2G2D phospholipase A2, group IID 0.578494
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.558285
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.545093
LY96 lymphocyte antigen 96 0.534248
C9ORF3 chromosome 9 open reading frame 3 0.532314
CD79A CD79a molecule, immunoglobulin-associated alpha 0.529994
GRAP GRB2-related adaptor protein 0.52536
CCL11 chemokine (C-C motif) ligand 11 0.523816
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.51919
HIF3A hypoxia inducible factor 3, alpha subunit 0.518805
PDE4A phosphodiesterase 4A, cAMP-specific 0.517649
PER1 period circadian clock 1 0.514186
FBN1 fibrillin 1 0.513802
PGF placental growth factor 0.508041
IL17A interleukin 17A 0.507273
IL6 interleukin 6 0.504207
SFTPD surfactant protein D 0.501909
SOD2 superoxide dismutase 2, mitochondrial 0.488549
IL10 interleukin 10 0.483604
HSF4 heat shock transcription factor 4 0.480945
TACR3 tachykinin receptor 3 0.47753
FASLG Fas ligand (TNF superfamily, member 6) 0.474877
NOS2 nitric oxide synthase 2, inducible 0.47374
IL5 interleukin 5 0.465038
WDR13 WD repeat domain 13 0.456355
C5AR1 complement component 5a receptor 1 0.453339
LBR lamin B receptor 0.452585
CYS1 cystin 1 0.449947
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.443923
PRSS30P protease, serine, 30, pseudogene 0.443923
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.442418
ELANE elastase, neutrophil expressed 0.442418
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.43941
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.433021
HBA2 hemoglobin, alpha 2 0.43227
FAT3 FAT atypical cadherin 3 0.429642
TBP TATA box binding protein 0.423265
TGFB1 transforming growth factor, beta 1 0.419517
NOTCH1 notch 1 0.418768
C1QC complement component 1, q subcomponent, C chain 0.415024
TTN titin 0.415024
GPANK1 G patch domain and ankyrin repeats 1 0.413901
CALB2 calbindin 2 0.412779
PPT1 palmitoyl-protein thioesterase 1 0.407172
TSC1 tuberous sclerosis 1 0.405305
AGR3 anterior gradient 3 0.404184
FBXL15 F-box and leucine-rich repeat protein 15 0.400453
BMP2K BMP2 inducible kinase 0.396725
NPW neuropeptide W 0.396353
TUBE1 tubulin, epsilon 1 0.394491
PYCR1 pyrroline-5-carboxylate reductase 1 0.391885
ERAS ES cell expressed Ras 0.390769
MAN1A1 mannosidase, alpha, class 1A, member 1 0.387794
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.385936
CHD3 chromodomain helicase DNA binding protein 3 0.369997
PGR progesterone receptor 0.366671
IPP intracisternal A particle-promoted polypeptide 0.366301
CD34 CD34 molecule 0.363347
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 0.360764
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.354868
PLAT plasminogen activator, tissue 0.35082
PMF1 polyamine-modulated factor 1 0.346409
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.346042
TES testin LIM domain protein 0.345308
FGR FGR proto-oncogene, Src family tyrosine kinase 0.344941
SPAG1 sperm associated antigen 1 0.342739
PRCP prolylcarboxypeptidase (angiotensinase C) 0.337975
ADAM2 ADAM metallopeptidase domain 2 0.334681
ANXA1 annexin A1 0.334315
CCL5 chemokine (C-C motif) ligand 5 0.333218
CD68 CD68 molecule 0.329565
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.320817
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.320454
UNG uracil-DNA glycosylase 0.319726
HES5 hes family bHLH transcription factor 5 0.312464
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.310652
PRAMEF6 PRAME family member 6 0.309204
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.307395
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.303781
F3 coagulation factor III (thromboplastin, tissue factor) 0.301615
AVP arginine vasopressin 0.298011
IFI44 interferon-induced protein 44 0.284371
NTS neurotensin 0.283297
PPAT phosphoribosyl pyrophosphate amidotransferase 0.281868
PDZD4 PDZ domain containing 4 0.28151
TRAPPC9 trafficking protein particle complex 9 0.275801
HAGH hydroxyacylglutathione hydrolase 0.27153
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.264431
SPP1 secreted phosphoprotein 1 0.255594
ACE angiotensin I converting enzyme 0.252774
CP ceruloplasmin (ferroxidase) 0.252774
PTPRE protein tyrosine phosphatase, receptor type, E 0.251366
TTC34 tetratricopeptide repeat domain 34 0.24996
BIN2 bridging integrator 2 0.249257
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.246799
PARP1 poly (ADP-ribose) polymerase 1 0.246448
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.244345
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.239799
DNASE1 deoxyribonuclease I 0.232836
CYGB cytoglobin 0.232142
IFI27 interferon, alpha-inducible protein 27 0.227642
FTH1 ferritin, heavy polypeptide 1 0.22454
TSC22D3 TSC22 domain family, member 3 0.223509
HRH4 histamine receptor H4 0.222822
DCSTAMP dendrocyte expressed seven transmembrane protein 0.222479
HLA-C major histocompatibility complex, class I, C 0.222136
PER2 period circadian clock 2 0.216672
AHSP alpha hemoglobin stabilizing protein 0.216332
SCYL1 SCY1-like 1 (S. cerevisiae) 0.214297
WRAP73 WD repeat containing, antisense to TP73 0.213283
BAX BCL2-associated X protein 0.212608
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.210925
TOP3A topoisomerase (DNA) III alpha 0.209248
PRTN3 proteinase 3 0.204923
ESR1 estrogen receptor 1 0.203933
SFTPB surfactant protein B 0.203275
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.201635
AMD1 adenosylmethionine decarboxylase 1 0.197742
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.197742
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.197742
NDEL1 nudE neurodevelopment protein 1-like 1 0.196139
DPEP1 dipeptidase 1 (renal) 0.195501
SPA17 sperm autoantigenic protein 17 0.194865
HSF1 heat shock transcription factor 1 0.193285
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.192971
RERE arginine-glutamic acid dipeptide (RE) repeats 0.190786
C1QB complement component 1, q subcomponent, B chain 0.190168
AURKAIP1 aurora kinase A interacting protein 1 0.18651
UST uronyl-2-sulfotransferase 0.18472
BLVRA biliverdin reductase A 0.18472
PPARA peroxisome proliferator-activated receptor alpha 0.183248
FGG fibrinogen gamma chain 0.17952
CDKN2A cyclin-dependent kinase inhibitor 2A 0.176215
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.175679
SELL selectin L 0.173057
DYNLRB1 dynein, light chain, roadblock-type 1 0.172544
IGLV5-52 immunoglobulin lambda variable 5-52 0.170054
F2 coagulation factor II (thrombin) 0.168148
CD1B CD1b molecule 0.165001
FTL ferritin, light polypeptide 0.164786
PATE1 prostate and testis expressed 1 0.164571
CCL25 chemokine (C-C motif) ligand 25 0.163729
ZMYND10 zinc finger, MYND-type containing 10 0.163111
C1QA complement component 1, q subcomponent, A chain 0.162908
CLCN6 chloride channel, voltage-sensitive 6 0.162505
SMTNL1 smoothelin-like 1 0.162505
WDFY2 WD repeat and FYVE domain containing 2 0.160948
SGOL1 shugoshin-like 1 (S. pombe) 0.158951
RORA RAR-related orphan receptor A 0.158778
KRT19 keratin 19, type I 0.158605
RHOA ras homolog family member A 0.158605
AVPR2 arginine vasopressin receptor 2 0.144721
NOVA2 neuro-oncological ventral antigen 2 0.144529
MMD monocyte to macrophage differentiation-associated 0.138063
CPSF3L cleavage and polyadenylation specific factor 3-like 0.13701
IRAK4 interleukin-1 receptor-associated kinase 4 0.136729
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.136614
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.136403
USF2 upstream transcription factor 2, c-fos interacting 0.135846
ATN1 atrophin 1 0.135519
TREM1 triggering receptor expressed on myeloid cells 1 0.134864
TNNT2 troponin T type 2 (cardiac) 0.131666
VIL1 villin 1 0.130944
CD7 CD7 molecule 0.130499
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.129305
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.126136
NF1 neurofibromin 1 0.125975
FAM155B family with sequence similarity 155, member B 0.125671
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.125576
PLCE1 phospholipase C, epsilon 1 0.125457
ULK1 unc-51 like autophagy activating kinase 1 0.125192
SMOX spermine oxidase 0.125142
TPO thyroid peroxidase 0.124823
TP53 tumor protein p53 0.124747
FBLN5 fibulin 5 0.124569
LARS leucyl-tRNA synthetase 0.123818
CDAN1 codanin 1 0.123791
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.123791
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.123658
HIST2H2AC histone cluster 2, H2ac 0.123522
HIST2H2AA3 histone cluster 2, H2aa3 0.123495
HIST2H2AA4 histone cluster 2, H2aa4 0.123495
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.123386
EPX eosinophil peroxidase 0.123278
FSCN1 fascin actin-bundling protein 1 0.123169
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.123085
ACOT13 acyl-CoA thioesterase 13 0.122805
HRH1 histamine receptor H1 0.12229
PDPN podoplanin 0.12229
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.122261
FHL1 four and a half LIM domains 1 0.122058
SH2D1A SH2 domain containing 1A 0.121671
IGLV3-9 immunoglobulin lambda variable 3-9 (gene/pseudogene) 0.121431
FOXD3 forkhead box D3 0.121094
KEL Kell blood group, metallo-endopeptidase 0.121063
GABARAP GABA(A) receptor-associated protein 0.120659
PAX5 paired box 5 0.120274
THEM4 thioesterase superfamily member 4 0.119985
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.119852
SST somatostatin 0.11972
PTAFR platelet-activating factor receptor 0.119521
DUT deoxyuridine triphosphatase 0.119288
GUSB glucuronidase, beta 0.119186
PAOX polyamine oxidase (exo-N4-amino) 0.118912
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.118844
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.118844
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.118844
CDK11A cyclin-dependent kinase 11A 0.118707
TFEB transcription factor EB 0.118673
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.118569
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 0.118286
EPCAM epithelial cell adhesion molecule 0.117716
CCR3 chemokine (C-C motif) receptor 3 0.117169
JMJD6 jumonji domain containing 6 0.117058
EED embryonic ectoderm development 0.116832
ACOT7 acyl-CoA thioesterase 7 0.116719
ECI1 enoyl-CoA delta isomerase 1 0.116606
UBAP1 ubiquitin associated protein 1 0.116456
BTNL2 butyrophilin-like 2 0.116343
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.116033
SETD2 SET domain containing 2 0.115605
HBD hemoglobin, delta 0.115448
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.115408
CD6 CD6 molecule 0.115127
C5 complement component 5 0.115047
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.114967
AZU1 azurocidin 1 0.113984
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.113521
CFI complement factor I 0.113479
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.113436
BIN1 bridging integrator 1 0.113308
SARS seryl-tRNA synthetase 0.112442
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.112047
CD19 CD19 molecule 0.112004
CD24 CD24 molecule 0.111958
F13A1 coagulation factor XIII, A1 polypeptide 0.111823
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.111732
CLCNKB chloride channel, voltage-sensitive Kb 0.111732
SP100 SP100 nuclear antigen 0.111506
SETD1A SET domain containing 1A 0.111461
BDKRB2 bradykinin receptor B2 0.111235
PTH parathyroid hormone 0.110868
GYPA glycophorin A (MNS blood group) 0.110775
NCAM1 neural cell adhesion molecule 1 0.110589
IFNG interferon, gamma 0.110589
TGFB2 transforming growth factor, beta 2 0.110496
IL12B interleukin 12B 0.110449
FPR1 formyl peptide receptor 1 0.109407