pleural cancer Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A connective tissue cancer that located_in the pleura. (Human Disease Ontology, DOID_5158)
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Genes

221 genes co-occuring with the disease pleural cancer in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MSLN mesothelin 2.21164
CALB2 calbindin 2 1.7159
TYMS thymidylate synthetase 1.3193
SPP1 secreted phosphoprotein 1 1.21912
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 1.20266
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1.18798
FPGS folylpolyglutamate synthase 1.06396
TMEM30B transmembrane protein 30B 1.0606
BIRC5 baculoviral IAP repeat containing 5 1.0383
KRT5 keratin 5, type II 1.02861
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.00203
CCAR1 cell division cycle and apoptosis regulator 1 0.991065
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.985164
WT1 Wilms tumor 1 0.941611
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.898693
EGFR epidermal growth factor receptor 0.895
ERCC1 excision repair cross-complementation group 1 0.888438
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.881472
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.848307
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.843802
MAPK13 mitogen-activated protein kinase 13 0.837656
ANKRD11 ankyrin repeat domain 11 0.808949
DHFR dihydrofolate reductase 0.808539
SLC7A14 solute carrier family 7, member 14 0.795821
SULF1 sulfatase 1 0.795821
MIR1273D microRNA 1273d 0.775341
BCL2L1 BCL2-like 1 0.773296
TP53 tumor protein p53 0.770027
MARS methionyl-tRNA synthetase 0.750864
TUSC2 tumor suppressor candidate 2 0.745578
NF2 neurofibromin 2 (merlin) 0.74436
ILK integrin-linked kinase 0.743954
CD86 CD86 molecule 0.725311
CAPS calcyphosine 0.713601
PDPN podoplanin 0.711989
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.711587
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.709572
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.695103
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.681894
CDKN2A cyclin-dependent kinase inhibitor 2A 0.677903
SP1 Sp1 transcription factor 0.666358
THBD thrombomodulin 0.66596
TRIP6 thyroid hormone receptor interactor 6 0.65565
CD34 CD34 molecule 0.651694
MYO18B myosin XVIIIB 0.639463
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.635135
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.634742
NFRKB nuclear factor related to kappaB binding protein 0.615921
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.615921
IL2 interleukin 2 0.612011
VEGFA vascular endothelial growth factor A 0.60342
OXA1L oxidase (cytochrome c) assembly 1-like 0.60186
BAX BCL2-associated X protein 0.60186
PUF60 poly-U binding splicing factor 60KDa 0.59913
PDYN prodynorphin 0.587444
TM4SF1 transmembrane 4 L six family member 1 0.586665
ASS1 argininosuccinate synthase 1 0.57655
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.563335
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.561392
AGGF1 angiogenic factor with G patch and FHA domains 1 0.560616
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.560227
TENM2 teneurin transmembrane protein 2 0.558674
XAF1 XIAP associated factor 1 0.553627
CLDN15 claudin 15 0.544705
TOP2A topoisomerase (DNA) II alpha 170kDa 0.526904
TNIP1 TNFAIP3 interacting protein 1 0.526904
GOLIM4 golgi integral membrane protein 4 0.526132
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.518805
PISD phosphatidylserine decarboxylase 0.514186
DVL1 dishevelled segment polarity protein 1 0.514186
PTEN phosphatase and tensin homolog 0.511496
NDC80 NDC80 kinetochore complex component 0.511112
CD274 CD274 molecule 0.510344
KAT7 K(lysine) acetyltransferase 7 0.508808
TNS1 tensin 1 0.506123
ITLN1 intelectin 1 (galactofuranose binding) 0.503824
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.503441
EIF4A2 eukaryotic translation initiation factor 4A2 0.494648
INCENP inner centromere protein antigens 135/155kDa 0.492359
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.488169
IL4R interleukin 4 receptor 0.488169
WAC WW domain containing adaptor with coiled-coil 0.482084
MANEA mannosidase, endo-alpha 0.481325
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.470332
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.449571
RTN4R reticulon 4 receptor 0.446935
PEA15 phosphoprotein enriched in astrocytes 15 0.446558
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.445052
ACTG2 actin, gamma 2, smooth muscle, enteric 0.435275
BIRC7 baculoviral IAP repeat containing 7 0.433772
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.43227
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.427015
MCAM melanoma cell adhesion molecule 0.41727
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.412779
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.409787
ESR2 estrogen receptor 2 (ER beta) 0.401945
SMO smoothened, frizzled class receptor 0.401945
PLXNA1 plexin A1 0.400826
ZIC1 Zic family member 1 0.399334
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.397471
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.393001
EFNB2 ephrin-B2 0.391141
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.390025
BST1 bone marrow stromal cell antigen 1 0.380739
SOCS1 suppressor of cytokine signaling 1 0.377402
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.369628
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.360764
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.360395
DVL3 dishevelled segment polarity protein 3 0.360026
CCNB1 cyclin B1 0.357077
BIRC3 baculoviral IAP repeat containing 3 0.356709
SDC1 syndecan 1 0.353763
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.353763
MCM2 minichromosome maintenance complex component 2 0.353027
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.353027
EMX2 empty spiracles homeobox 2 0.35082
HAPLN1 hyaluronan and proteoglycan link protein 1 0.35082
FGFR1 fibroblast growth factor receptor 1 0.345675
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.345675
IL32 interleukin 32 0.344207
TPM4 tropomyosin 4 0.342006
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.341639
CAV1 caveolin 1, caveolae protein, 22kDa 0.335778
MAPK3 mitogen-activated protein kinase 3 0.332487
CCND1 cyclin D1 0.332487
NME1-NME2 NME1-NME2 readthrough 0.332121
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.331391
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.326646
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.317182
MIR145 microRNA 145 0.312102
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.311014
CUL4A cullin 4A 0.310652
CMA1 chymase 1, mast cell 0.304142
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.300533
GLI1 GLI family zinc finger 1 0.297291
FGF2 fibroblast growth factor 2 (basic) 0.292616
LPAR2 lysophosphatidic acid receptor 2 0.28616
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.285086
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.280796
CD44 CD44 molecule (Indian blood group) 0.279011
HAT1 histone acetyltransferase 1 0.274021
KDR kinase insert domain receptor 0.274021
DCSTAMP dendrocyte expressed seven transmembrane protein 0.26514
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.264431
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.263368
TICAM2 toll-like receptor adaptor molecule 2 0.259124
MCM7 minichromosome maintenance complex component 7 0.255946
NT5C2 5'-nucleotidase, cytosolic II 0.254888
FUT2 fucosyltransferase 2 (secretor status included) 0.253831
EPHA2 EPH receptor A2 0.251718
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.24996
NRP2 neuropilin 2 0.248905
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.24715
FNDC3A fibronectin type III domain containing 3A 0.246799
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.244696
USP9X ubiquitin specific peptidase 9, X-linked 0.241895
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.241546
NKX2-1 NK2 homeobox 1 0.240497
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.240148
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.240148
GSTA2 glutathione S-transferase alpha 2 0.238403
GSTA4 glutathione S-transferase alpha 4 0.237357
RAB1A RAB1A, member RAS oncogene family 0.235268
IGFBP4 insulin-like growth factor binding protein 4 0.234225
BIRC2 baculoviral IAP repeat containing 2 0.232142
PDPK1 3-phosphoinositide dependent protein kinase 1 0.230755
SFRP1 secreted frizzled-related protein 1 0.227988
HHIP hedgehog interacting protein 0.227642
SSTR4 somatostatin receptor 4 0.226607
RAD21 RAD21 homolog (S. pombe) 0.223853
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.220766
ZEB1 zinc finger E-box binding homeobox 1 0.220424
TPBG trophoblast glycoprotein 0.220424
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.220081
TXN thioredoxin 0.219398
LGALS3 lectin, galactoside-binding, soluble, 3 0.212608
VEGFC vascular endothelial growth factor C 0.212271
PLCH2 phospholipase C, eta 2 0.211597
RAD23B RAD23 homolog B (S. cerevisiae) 0.211261
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.210253
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.208579
HRK harakiri, BCL2 interacting protein 0.208579
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.207245
HDAC9 histone deacetylase 9 0.20658
TNNT1 troponin T type 1 (skeletal, slow) 0.20658
POSTN periostin, osteoblast specific factor 0.202618
IFITM1 interferon induced transmembrane protein 1 0.198064
FOXP3 forkhead box P3 0.195501
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.192971
CD1D CD1d molecule 0.190476
MIR214 microRNA 214 0.190168
KEL Kell blood group, metallo-endopeptidase 0.188632
MIR192 microRNA 192 0.188632
ALDOA aldolase A, fructose-bisphosphate 0.187719
SLC16A4 solute carrier family 16, member 4 0.186811
KRT7 keratin 7, type II 0.185612
NKX6-2 NK6 homeobox 2 0.182957
ENO2 enolase 2 (gamma, neuronal) 0.18151
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.181222
CRP C-reactive protein, pentraxin-related 0.180937
INVS inversin 0.179239
IRF6 interferon regulatory factor 6 0.178126
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.173571
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.172038
C19ORF48 chromosome 19 open reading frame 48 0.171785
SFRP5 secreted frizzled-related protein 5 0.171286
CSF1R colony stimulating factor 1 receptor 0.171036
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.170299
DIABLO diablo, IAP-binding mitochondrial protein 0.166995
GABARAP GABA(A) receptor-associated protein 0.165655
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.165001
FXYD1 FXYD domain containing ion transport regulator 1 0.163729
CPSF3L cleavage and polyadenylation specific factor 3-like 0.162908
CD46 CD46 molecule, complement regulatory protein 0.162707
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.162109
SOD2 superoxide dismutase 2, mitochondrial 0.161331
SPHK2 sphingosine kinase 2 0.160574
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.157765
EPCAM epithelial cell adhesion molecule 0.15046
CD68 CD68 molecule 0.142381
PTPRC protein tyrosine phosphatase, receptor type, C 0.136081