platelet dense granule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. (Gene Ontology, GO_0042827)
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Genes

76 proteins co-occuring with the platelet dense granule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
HPS1 Hermansky-Pudlak syndrome 1 2.34001
HPS3 Hermansky-Pudlak syndrome 3 2.32243
AP3B1 adaptor-related protein complex 3, beta 1 subunit 2.05758
HPS4 Hermansky-Pudlak syndrome 4 1.87934
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 1.76626
HPS5 Hermansky-Pudlak syndrome 5 1.66901
CD63 CD63 molecule 1.44234
RAB38 RAB38, member RAS oncogene family 1.42373
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 1.40131
SLC35D3 solute carrier family 35, member D3 1.32817
RAB27A RAB27A, member RAS oncogene family 1.1803
RABGGTA Rab geranylgeranyltransferase, alpha subunit 1.05488
PF4 platelet factor 4 1.02181
HPS6 Hermansky-Pudlak syndrome 6 0.992693
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.980016
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.966956
RAB27B RAB27B, member RAS oncogene family 0.854798
LYST lysosomal trafficking regulator 0.852961
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 0.839187
TYRP1 tyrosinase-related protein 1 0.774558
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.740965
RAB32 RAB32, member RAS oncogene family 0.735565
DTNBP1 dystrobrevin binding protein 1 0.690326
ZBTB14 zinc finger and BTB domain containing 14 0.677673
MREG melanoregulin 0.647862
RUNX1 runt-related transcription factor 1 0.634159
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.626483
F5 coagulation factor V (proaccelerin, labile factor) 0.60444
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.594753
NBEA neurobeachin 0.583431
F2R coagulation factor II (thrombin) receptor 0.550599
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.547297
VWF von Willebrand factor 0.544823
UXT ubiquitously-expressed, prefoldin-like chaperone 0.53906
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.536183
RAB31 RAB31, member RAS oncogene family 0.53413
ZIC1 Zic family member 1 0.515716
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 0.50107
WRNIP1 Werner helicase interacting protein 1 0.461199
CYTH2 cytohesin 2 0.4425
STX2 syntaxin 2 0.419644
TYR tyrosinase 0.417294
GP6 glycoprotein VI (platelet) 0.40675
UNC13D unc-13 homolog D (C. elegans) 0.40675
VASP vasodilator-stimulated phosphoprotein 0.404415
LIG3 ligase III, DNA, ATP-dependent 0.392775
GADD45G growth arrest and DNA-damage-inducible, gamma 0.392388
SLC45A2 solute carrier family 45, member 2 0.384665
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.367006
USO1 USO1 vesicle transport factor 0.362804
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.36204
OCA2 oculocutaneous albinism II 0.359371
MYO5A myosin VA (heavy chain 12, myoxin) 0.349484
SYTL4 synaptotagmin-like 4 0.331342
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.318205
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.302168
PRDX5 peroxiredoxin 5 0.289938
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.289199
SNAPIN SNAP-associated protein 0.271533
KIAA0101 KIAA0101 0.268969
TLN1 talin 1 0.26166
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.255107
CPB2 carboxypeptidase B2 (plasma) 0.245323
LAMP1 lysosomal-associated membrane protein 1 0.231672
EXOC2 exocyst complex component 2 0.231672
ADORA2A adenosine A2a receptor 0.22385
LAMP2 lysosomal-associated membrane protein 2 0.21228
MLPH melanophilin 0.203699
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.174635
AIRE autoimmune regulator 0.173543
CNOT2 CCR4-NOT transcription complex, subunit 2 0.170371
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.167856
SYK spleen tyrosine kinase 0.165697
FPR1 formyl peptide receptor 1 0.160053
PLD2 phospholipase D2 0.15776
TBX1 T-box 1 0.156513