platelet alpha granule Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). (Gene Ontology, GO_0031091)
External Link http://amigo.geneontology.org/amigo/term/GO:0031091
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Genes

14 proteins localized to the platelet alpha granule cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STXBP1 syntaxin binding protein 1
STXBP3 syntaxin binding protein 3
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TREML1 triggering receptor expressed on myeloid cells-like 1
VAMP7 vesicle-associated membrane protein 7
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VWF von Willebrand factor