platelet alpha granule Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). (Gene Ontology, GO_0031091)
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60 proteins localized to the platelet alpha granule cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.663342
TREML1 triggering receptor expressed on myeloid cells-like 1 0.663342
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.663342
STXBP1 syntaxin binding protein 1 0.663342
STXBP3 syntaxin binding protein 3 0.663342
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.663342
THBS2 thrombospondin 2 0.663342
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.663342
VWF von Willebrand factor 0.663342
ALDOA aldolase A, fructose-bisphosphate 0.237908
ALB albumin 0.237908
KNG1 kininogen 1 0.237908
CLU clusterin 0.237908
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.237908
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.237908
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.237908
TGFB3 transforming growth factor, beta 3 0.237908
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.237908
TGFB2 transforming growth factor, beta 2 0.237908
CD9 CD9 molecule 0.237908
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.237908
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.237908
PROS1 protein S (alpha) 0.237908
F8 coagulation factor VIII, procoagulant component 0.237908
F5 coagulation factor V (proaccelerin, labile factor) 0.237908
THBS1 thrombospondin 1 0.237908
EGF epidermal growth factor 0.237908
A2M alpha-2-macroglobulin 0.237908
SRGN serglycin 0.237908
PLG plasminogen 0.237908
GAS6 growth arrest-specific 6 0.237908
TGFB1 transforming growth factor, beta 1 0.237908
LEFTY2 left-right determination factor 2 0.237908
TMSB4X thymosin beta 4, X-linked 0.237908
CFD complement factor D (adipsin) 0.237908
IGF1 insulin-like growth factor 1 (somatomedin C) 0.237908
IGF2 insulin-like growth factor 2 0.237908
FGB fibrinogen beta chain 0.237908
FGA fibrinogen alpha chain 0.237908
FGG fibrinogen gamma chain 0.237908
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.237908
ACTN4 actinin, alpha 4 0.237908
ACTN1 actinin, alpha 1 0.237908
ACTN2 actinin, alpha 2 0.237908
TIMP1 TIMP metallopeptidase inhibitor 1 0.237908
PF4 platelet factor 4 0.237908
APP amyloid beta (A4) precursor protein 0.237908
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.237908
FN1 fibronectin 1 0.237908
VEGFB vascular endothelial growth factor B 0.237908
VEGFC vascular endothelial growth factor C 0.237908
VEGFA vascular endothelial growth factor A 0.237908
HRG histidine-rich glycoprotein 0.237908
CD36 CD36 molecule (thrombospondin receptor) 0.237908
MMRN1 multimerin 1 0.237908
PDGFB platelet-derived growth factor beta polypeptide 0.237908
PDGFA platelet-derived growth factor alpha polypeptide 0.237908
F13A1 coagulation factor XIII, A1 polypeptide 0.237908
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.237908
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.098109