platelet activation Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. (Gene Ontology, GO_0030168)
External Link http://amigo.geneontology.org/amigo/term/GO:0030168
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Genes

204 genes participating in the platelet activation biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN4 actinin, alpha 4
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALDOA aldolase A, fructose-bisphosphate
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOA1 apolipoprotein A-I
APP amyloid beta (A4) precursor protein
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
AXL AXL receptor tyrosine kinase
BCAR1 breast cancer anti-estrogen resistance 1
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3
BRPF3 bromodomain and PHD finger containing, 3
C1GALT1C1 C1GALT1-specific chaperone 1
CALU calumenin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD63 CD63 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
CFL1 cofilin 1 (non-muscle)
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
DAGLA diacylglycerol lipase, alpha
DAGLB diacylglycerol lipase, beta
DGKA diacylglycerol kinase, alpha 80kDa
DGKB diacylglycerol kinase, beta 90kDa
DGKD diacylglycerol kinase, delta 130kDa
DGKE diacylglycerol kinase, epsilon 64kDa
DGKG diacylglycerol kinase, gamma 90kDa
DGKH diacylglycerol kinase, eta
DGKI diacylglycerol kinase, iota
DGKK diacylglycerol kinase, kappa
DGKQ diacylglycerol kinase, theta 110kDa
DGKZ diacylglycerol kinase, zeta
EGF epidermal growth factor
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLNA filamin A, alpha
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD6 frizzled class receptor 6
GAS6 growth arrest-specific 6
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAT3 guanine nucleotide binding protein, alpha transducing 3
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP5 glycoprotein V (platelet)
GP6 glycoprotein VI (platelet)
GP9 glycoprotein IX (platelet)
GRB2 growth factor receptor-bound protein 2
HABP4 hyaluronan binding protein 4
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HRG histidine-rich glycoprotein
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL6 interleukin 6
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KNG1 kininogen 1
LAMP2 lysosomal-associated membrane protein 2
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEFTY2 left-right determination factor 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MERTK MER proto-oncogene, tyrosine kinase
MGLL monoglyceride lipase
MMRN1 multimerin 1
MPL MPL proto-oncogene, thrombopoietin receptor
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PFN1 profilin 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEK pleckstrin
PLG plasminogen
PLSCR1 phospholipid scramblase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PROS1 protein S (alpha)
PSAP prosaposin
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOG ras homolog family member G
SAA1 serum amyloid A1
SCG3 secretogranin III
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRGN serglycin
STX4 syntaxin 4
STXBP3 syntaxin binding protein 3
SYK spleen tyrosine kinase
TBXA2R thromboxane A2 receptor
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
THPO thrombopoietin
TIMP1 TIMP metallopeptidase inhibitor 1
TLN1 talin 1
TMSB4X thymosin beta 4, X-linked
TREML1 triggering receptor expressed on myeloid cells-like 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TTN titin
TUBA4A tubulin, alpha 4a
TYRO3 TYRO3 protein tyrosine kinase
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VCL vinculin
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
WDR1 WD repeat domain 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta