pivmecillinam-3535 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the pivmecillinam-3535 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACTL8 actin-like 8
ALDOB aldolase B, fructose-bisphosphate
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF6B activating transcription factor 6 beta
B9D1 B9 protein domain 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF66 chromosome 19 open reading frame 66
CALML5 calmodulin-like 5
CC2D1A coiled-coil and C2 domain containing 1A
CCDC85B coiled-coil domain containing 85B
CD58 CD58 molecule
CDK18 cyclin-dependent kinase 18
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLDN6 claudin 6
CRHR2 corticotropin releasing hormone receptor 2
CTBP2 C-terminal binding protein 2
DCAF11 DDB1 and CUL4 associated factor 11
DDIT3 DNA-damage-inducible transcript 3
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DOPEY2 dopey family member 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FOSL2 FOS-like antigen 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GFI1 growth factor independent 1 transcription repressor
GLIPR1 GLI pathogenesis-related 1
GPATCH3 G patch domain containing 3
GPR143 G protein-coupled receptor 143
HDAC11 histone deacetylase 11
HDAC5 histone deacetylase 5
HLA-G major histocompatibility complex, class I, G
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IGL immunoglobulin lambda locus
KIF22 kinesin family member 22
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT85 keratin 85, type II
LIG3 ligase III, DNA, ATP-dependent
MARS methionyl-tRNA synthetase
MFGE8 milk fat globule-EGF factor 8 protein
MMP3 matrix metallopeptidase 3
NEB nebulin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPAS2 neuronal PAS domain protein 2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSGIN1 oxidative stress induced growth inhibitor 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE3B phosphodiesterase 3B, cGMP-inhibited
PER1 period circadian clock 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLLP plasmolipin
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POMT2 protein-O-mannosyltransferase 2
PSEN1 presenilin 1
PXN paxillin
RAB30 RAB30, member RAS oncogene family
RARA retinoic acid receptor, alpha
REPS1 RALBP1 associated Eps domain containing 1
RGS12 regulator of G-protein signaling 12
RHOT2 ras homolog family member T2
RIMS3 regulating synaptic membrane exocytosis 3
RTEL1 regulator of telomere elongation helicase 1
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
SAFB2 scaffold attachment factor B2
SIX1 SIX homeobox 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SMTN smoothelin
SNX13 sorting nexin 13
SOX15 SRY (sex determining region Y)-box 15
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STEAP4 STEAP family member 4
STRA6 stimulated by retinoic acid 6
SYNJ1 synaptojanin 1
TEP1 telomerase-associated protein 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM209 transmembrane protein 209
TMEM212 transmembrane protein 212
TMEM254 transmembrane protein 254
TMEM8B transmembrane protein 8B
TREX1 three prime repair exonuclease 1
WWOX WW domain containing oxidoreductase
YTHDC2 YTH domain containing 2
ZER1 zyg-11 related, cell cycle regulator

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD17B abhydrolase domain containing 17B
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACAD10 acyl-CoA dehydrogenase family, member 10
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ADTRP androgen-dependent TFPI-regulating protein
ANXA2P3 annexin A2 pseudogene 3
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCNO cyclin O
CDK3 cyclin-dependent kinase 3
CENPO centromere protein O
CNGB3 cyclic nucleotide gated channel beta 3
CORT cortistatin
CTAGE9 CTAGE family, member 9
EFNA3 ephrin-A3
ELP6 elongator acetyltransferase complex subunit 6
EN2 engrailed homeobox 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
F2R coagulation factor II (thrombin) receptor
FABP6 fatty acid binding protein 6, ileal
FAM46C family with sequence similarity 46, member C
FLNC filamin C, gamma
FLRT3 fibronectin leucine rich transmembrane protein 3
FRMD1 FERM domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLRA1 glycine receptor, alpha 1
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPR157 G protein-coupled receptor 157
GPR87 G protein-coupled receptor 87
HDAC4 histone deacetylase 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AK histone cluster 1, H2ak
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
INPP1 inositol polyphosphate-1-phosphatase
INPP5J inositol polyphosphate-5-phosphatase J
IRF1 interferon regulatory factor 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD4 jumonji domain containing 4
KDM8 lysine (K)-specific demethylase 8
LARP6 La ribonucleoprotein domain family, member 6
LIME1 Lck interacting transmembrane adaptor 1
LINS lines homolog (Drosophila)
LRRC20 leucine rich repeat containing 20
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
NES nestin
NNAT neuronatin
NOD1 nucleotide-binding oligomerization domain containing 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OCLM oculomedin
ONECUT2 one cut homeobox 2
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB13 protocadherin beta 13
PGPEP1 pyroglutamyl-peptidase I
PODXL2 podocalyxin-like 2
POM121 POM121 transmembrane nucleoporin
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR14L proline rich 14-like
PTK6 protein tyrosine kinase 6
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF170 ring finger protein 170
RPGRIP1L RPGRIP1-like
RUSC2 RUN and SH3 domain containing 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SREK1IP1 SREK1-interacting protein 1
SULT4A1 sulfotransferase family 4A, member 1
TCP10 t-complex 10
TET3 tet methylcytosine dioxygenase 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFB3 transforming growth factor, beta 3
TMEM104 transmembrane protein 104
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOM1 target of myb1 (chicken)
TRAIP TRAF interacting protein
TSGA10 testis specific, 10
TSPAN5 tetraspanin 5
TUBA3D tubulin, alpha 3d
VLDLR very low density lipoprotein receptor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XAB2 XPA binding protein 2
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF250 zinc finger protein 250
ZNF34 zinc finger protein 34
ZNF747 zinc finger protein 747
ZNF750 zinc finger protein 750