pirlindole-6519 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the pirlindole-6519 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAM22 ADAM metallopeptidase domain 22
AK2 adenylate kinase 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
AOC3 amine oxidase, copper containing 3
APOC1 apolipoprotein C-I
ARTN artemin
ASPH aspartate beta-hydroxylase
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BMP5 bone morphogenetic protein 5
BTN3A3 butyrophilin, subfamily 3, member A3
CALCOCO1 calcium binding and coiled-coil domain 1
CALD1 caldesmon 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCDC93 coiled-coil domain containing 93
CEP164 centrosomal protein 164kDa
CFAP69 cilia and flagella associated protein 69
CREBBP CREB binding protein
DDN dendrin
DENND1C DENN/MADD domain containing 1C
DGAT1 diacylglycerol O-acyltransferase 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOK4 docking protein 4
ELOVL5 ELOVL fatty acid elongase 5
ESR1 estrogen receptor 1
EXOSC1 exosome component 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FRMD1 FERM domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FYB FYN binding protein
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
HDAC11 histone deacetylase 11
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HOMER3 homer scaffolding protein 3
IHH indian hedgehog
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCTD17 potassium channel tetramerization domain containing 17
LAT2 linker for activation of T cells family, member 2
LDB3 LIM domain binding 3
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBD1 methyl-CpG binding domain protein 1
MBD3 methyl-CpG binding domain protein 3
MCC mutated in colorectal cancers
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MSI1 musashi RNA-binding protein 1
MVD mevalonate (diphospho) decarboxylase
MYO7A myosin VIIA
NCKIPSD NCK interacting protein with SH3 domain
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OMD osteomodulin
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PHOX2A paired-like homeobox 2a
PIDD1 p53-induced death domain protein 1
PLAC4 placenta-specific 4
PLCE1 phospholipase C, epsilon 1
PLSCR4 phospholipid scramblase 4
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PRKG2 protein kinase, cGMP-dependent, type II
PTPRA protein tyrosine phosphatase, receptor type, A
RBFA ribosome binding factor A (putative)
RBM12B RNA binding motif protein 12B
RCAN1 regulator of calcineurin 1
RNF43 ring finger protein 43
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL7 ribosomal protein L7
RPS4Y1 ribosomal protein S4, Y-linked 1
SIRT4 sirtuin 4
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SNRPN small nuclear ribonucleoprotein polypeptide N
SOD3 superoxide dismutase 3, extracellular
STMN4 stathmin-like 4
SULT4A1 sulfotransferase family 4A, member 1
SYNJ2 synaptojanin 2
TBX5 T-box 5
TEK TEK tyrosine kinase, endothelial
TLDC1 TBC/LysM-associated domain containing 1
TLN1 talin 1
TMEM212 transmembrane protein 212
TOP3A topoisomerase (DNA) III alpha
TRAPPC9 trafficking protein particle complex 9
TRIL TLR4 interactor with leucine-rich repeats
TRIM68 tripartite motif containing 68
TUBGCP3 tubulin, gamma complex associated protein 3
ULBP1 UL16 binding protein 1
VIPR2 vasoactive intestinal peptide receptor 2
WDR91 WD repeat domain 91
ZBTB39 zinc finger and BTB domain containing 39

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTL8 actin-like 8
ANP32A-IT1 ANP32A intronic transcript 1
ARHGAP4 Rho GTPase activating protein 4
ASB7 ankyrin repeat and SOCS box containing 7
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
AUTS2 autism susceptibility candidate 2
BCORL1 BCL6 corepressor-like 1
BIRC7 baculoviral IAP repeat containing 7
C17ORF80 chromosome 17 open reading frame 80
C1ORF54 chromosome 1 open reading frame 54
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK20 cyclin-dependent kinase 20
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CORT cortistatin
CRLF1 cytokine receptor-like factor 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCAF17 DDB1 and CUL4 associated factor 17
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DOCK1 dedicator of cytokinesis 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC6L excision repair cross-complementation group 6-like
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FAM169A family with sequence similarity 169, member A
FAM86C1 family with sequence similarity 86, member C1
FBXL6 F-box and leucine-rich repeat protein 6
FGF23 fibroblast growth factor 23
FSCN1 fascin actin-bundling protein 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPR87 G protein-coupled receptor 87
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HCFC1 host cell factor C1
HIRA histone cell cycle regulator
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HSPB6 heat shock protein, alpha-crystallin-related, B6
IGSF1 immunoglobulin superfamily, member 1
IL17RA interleukin 17 receptor A
IMPG2 interphotoreceptor matrix proteoglycan 2
INPP5J inositol polyphosphate-5-phosphatase J
JMJD4 jumonji domain containing 4
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA0754 KIAA0754
KIAA1456 KIAA1456
KRT20 keratin 20, type I
KRT8P12 keratin 8 pseudogene 12
LAMP3 lysosomal-associated membrane protein 3
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC729164 hCG1732469
LRRC8E leucine rich repeat containing 8 family, member E
LY86 lymphocyte antigen 86
MT1H metallothionein 1H
MTA2 metastasis associated 1 family, member 2
MTERF4 mitochondrial transcription termination factor 4
MTSS1L metastasis suppressor 1-like
MYL5 myosin, light chain 5, regulatory
MYO1F myosin IF
NECAP2 NECAP endocytosis associated 2
NHEJ1 nonhomologous end-joining factor 1
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NSD1 nuclear receptor binding SET domain protein 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PDE8B phosphodiesterase 8B
PLAT plasminogen activator, tissue
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PRICKLE3 prickle homolog 3 (Drosophila)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB36 RAB36, member RAS oncogene family
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIBC2 RIB43A domain with coiled-coils 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SRD5A3 steroid 5 alpha-reductase 3
TET3 tet methylcytosine dioxygenase 3
TM6SF1 transmembrane 6 superfamily member 1
TMEM104 transmembrane protein 104
TMEM53 transmembrane protein 53
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM25 tripartite motif containing 25
UPK3B uroplakin 3B
VPS9D1 VPS9 domain containing 1
WDR4 WD repeat domain 4
ZBTB22 zinc finger and BTB domain containing 22
ZNF365 zinc finger protein 365
ZNF408 zinc finger protein 408
ZNF750 zinc finger protein 750