pirinixic acid-487 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pirinixic acid-487 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM2 adrenomedullin 2
AGRN agrin
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASCL1 achaete-scute family bHLH transcription factor 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C5ORF30 chromosome 5 open reading frame 30
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV3 caveolin 3
CCDC85C coiled-coil domain containing 85C
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD2AP CD2-associated protein
CD6 CD6 molecule
CDC42 cell division cycle 42
CES3 carboxylesterase 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CIB2 calcium and integrin binding family member 2
CRYAB crystallin, alpha B
CSN2 casein beta
DLEC1 deleted in lung and esophageal cancer 1
DOC2B double C2-like domains, beta
DRP2 dystrophin related protein 2
DUSP22 dual specificity phosphatase 22
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FLNC filamin C, gamma
GAL3ST4 galactose-3-O-sulfotransferase 4
GFOD2 glucose-fructose oxidoreductase domain containing 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIP2 glutamate receptor interacting protein 2
GSK3A glycogen synthase kinase 3 alpha
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IFI35 interferon-induced protein 35
IGHMBP2 immunoglobulin mu binding protein 2
IL16 interleukin 16
IL7R interleukin 7 receptor
KLHL25 kelch-like family member 25
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LINC00574 long intergenic non-protein coding RNA 574
LTBP4 latent transforming growth factor beta binding protein 4
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAPK8 mitogen-activated protein kinase 8
MBD2 methyl-CpG binding domain protein 2
MEP1B meprin A, beta
MOB3B MOB kinase activator 3B
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MXD4 MAX dimerization protein 4
MXRA5 matrix-remodelling associated 5
MYL10 myosin, light chain 10, regulatory
NDRG2 NDRG family member 2
OCLM oculomedin
OR10H3 olfactory receptor, family 10, subfamily H, member 3
PAX8 paired box 8
PDGFB platelet-derived growth factor beta polypeptide
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP prolactin-induced protein
PKNOX2 PBX/knotted 1 homeobox 2
POU5F1B POU class 5 homeobox 1B
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRB1 proline-rich protein BstNI subfamily 1
PSG9 pregnancy specific beta-1-glycoprotein 9
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PVRIG poliovirus receptor related immunoglobulin domain containing
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RARG retinoic acid receptor, gamma
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPLP2 ribosomal protein, large, P2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SH3D21 SH3 domain containing 21
SIX6 SIX homeobox 6
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMO smoothened, frizzled class receptor
SPDEF SAM pointed domain containing ETS transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
SSX3 synovial sarcoma, X breakpoint 3
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNGR1 synaptogyrin 1
TBL2 transducin (beta)-like 2
TCF3 transcription factor 3
TCP11L1 t-complex 11, testis-specific-like 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMPRSS5 transmembrane protease, serine 5
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP63 tumor protein p63
TPSB2 tryptase beta 2 (gene/pseudogene)
TSHZ2 teashirt zinc finger homeobox 2
TWF1 twinfilin actin binding protein 1
VEZT vezatin, adherens junctions transmembrane protein
WSCD1 WSC domain containing 1
ZMYND10 zinc finger, MYND-type containing 10
ZNF35 zinc finger protein 35

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
AGBL5 ATP/GTP binding protein-like 5
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ASB6 ankyrin repeat and SOCS box containing 6
AXIN1 axin 1
BCAS4 breast carcinoma amplified sequence 4
BRIX1 BRX1, biogenesis of ribosomes
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C7ORF43 chromosome 7 open reading frame 43
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDR2L cerebellar degeneration-related protein 2-like
CHN1 chimerin 1
CIC capicua transcriptional repressor
CLCA1 chloride channel accessory 1
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNTN1 contactin 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COMMD10 COMM domain containing 10
COPS7B COP9 signalosome subunit 7B
CRLF3 cytokine receptor-like factor 3
CROT carnitine O-octanoyltransferase
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND4C DENN/MADD domain containing 4C
DGCR2 DiGeorge syndrome critical region gene 2
DPEP1 dipeptidase 1 (renal)
EPS8 epidermal growth factor receptor pathway substrate 8
EXOC6B exocyst complex component 6B
FAM189B family with sequence similarity 189, member B
FASTKD3 FAST kinase domains 3
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GMEB1 glucocorticoid modulatory element binding protein 1
GP9 glycoprotein IX (platelet)
GREB1L growth regulation by estrogen in breast cancer-like
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GUCA1B guanylate cyclase activator 1B (retina)
GUSBP3 glucuronidase, beta pseudogene 3
HMG20A high mobility group 20A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL15RA interleukin 15 receptor, alpha
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
JAM3 junctional adhesion molecule 3
JOSD1 Josephin domain containing 1
KIF5A kinesin family member 5A
KLHL28 kelch-like family member 28
KREMEN2 kringle containing transmembrane protein 2
LGMN legumain
LOC440792 proline dehydrogenase (oxidase) 1 pseudogene
MON1B MON1 secretory trafficking family member B
MRPL19 mitochondrial ribosomal protein L19
MT4 metallothionein 4
MTERF4 mitochondrial transcription termination factor 4
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NABP2 nucleic acid binding protein 2
NADSYN1 NAD synthetase 1
NCS1 neuronal calcium sensor 1
NNAT neuronatin
NRSN2 neurensin 2
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PEX13 peroxisomal biogenesis factor 13
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCD1 phospholipase C, delta 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLIN3 perilipin 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRDM14 PR domain containing 14
PRND prion protein 2 (dublet)
PRPF39 pre-mRNA processing factor 39
PRPH2 peripherin 2 (retinal degeneration, slow)
QTRT1 queuine tRNA-ribosyltransferase 1
RAD54L RAD54-like (S. cerevisiae)
RANBP6 RAN binding protein 6
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNF11 ring finger protein 11
RNF141 ring finger protein 141
RPAP3 RNA polymerase II associated protein 3
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC10A3 solute carrier family 10, member 3
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TEX13B testis expressed 13B
TKFC triokinase/FMN cyclase
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TOE1 target of EGR1, member 1 (nuclear)
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TTI1 TELO2 interacting protein 1
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
VWA1 von Willebrand factor A domain containing 1
ZBED1 zinc finger, BED-type containing 1
ZFP36 ZFP36 ring finger protein
ZNF16 zinc finger protein 16
ZNF586 zinc finger protein 586