piretanide-6144 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the piretanide-6144 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACAN aggrecan
ACP5 acid phosphatase 5, tartrate resistant
ADORA3 adenosine A3 receptor
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANGPTL2 angiopoietin-like 2
AP1M2 adaptor-related protein complex 1, mu 2 subunit
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATP9B ATPase, class II, type 9B
BEST1 bestrophin 1
BGN biglycan
BIN1 bridging integrator 1
BPI bactericidal/permeability-increasing protein
CARF calcium responsive transcription factor
CD163 CD163 molecule
CD1A CD1a molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD84 CD84 molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEP164 centrosomal protein 164kDa
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLEC3B C-type lectin domain family 3, member B
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CPN2 carboxypeptidase N, polypeptide 2
CXCL6 chemokine (C-X-C motif) ligand 6
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DGCR2 DiGeorge syndrome critical region gene 2
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DISC1 disrupted in schizophrenia 1
DSTYK dual serine/threonine and tyrosine protein kinase
EFCAB11 EF-hand calcium binding domain 11
ERICH1 glutamate-rich 1
FCAR Fc fragment of IgA receptor
FKBP5 FK506 binding protein 5
FLT3 fms-related tyrosine kinase 3
FOXN2 forkhead box N2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GSK3A glycogen synthase kinase 3 alpha
HAB1 B1 for mucin
HIST1H3I histone cluster 1, H3i
HYAL1 hyaluronoglucosaminidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
KDM4B lysine (K)-specific demethylase 4B
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF9 Kruppel-like factor 9
KLHL36 kelch-like family member 36
KLK13 kallikrein-related peptidase 13
KLK2 kallikrein-related peptidase 2
LHFPL2 lipoma HMGIC fusion partner-like 2
LPCAT3 lysophosphatidylcholine acyltransferase 3
MAB21L1 mab-21-like 1 (C. elegans)
MAL mal, T-cell differentiation protein
MCM3AP minichromosome maintenance complex component 3 associated protein
MLH3 mutL homolog 3
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
NDE1 nudE neurodevelopment protein 1
NHLH1 nescient helix loop helix 1
OSBPL10 oxysterol binding protein-like 10
OXCT2 3-oxoacid CoA transferase 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAX5 paired box 5
PCNXL2 pecanex-like 2 (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PER1 period circadian clock 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PIGR polymeric immunoglobulin receptor
PLIN2 perilipin 2
PODXL2 podocalyxin-like 2
PRPH peripherin
PRSS2 protease, serine, 2 (trypsin 2)
RAB6A RAB6A, member RAS oncogene family
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAA4 serum amyloid A4, constitutive
SCAND2P SCAN domain containing 2 pseudogene
SCIN scinderin
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIRPA signal-regulatory protein alpha
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMYD2 SET and MYND domain containing 2
SNX1 sorting nexin 1
TBXA2R thromboxane A2 receptor
TEX14 testis expressed 14
TK2 thymidine kinase 2, mitochondrial
TMCC1 transmembrane and coiled-coil domain family 1
TMLHE trimethyllysine hydroxylase, epsilon
TMOD1 tropomodulin 1
TRAPPC9 trafficking protein particle complex 9
TRIM10 tripartite motif containing 10
TSC22D3 TSC22 domain family, member 3
TTC38 tetratricopeptide repeat domain 38
UBE2I ubiquitin-conjugating enzyme E2I
USP22 ubiquitin specific peptidase 22
WDR62 WD repeat domain 62

decreased expression

Symbol Name
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP9 aquaporin 9
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAK1 BCL2-antagonist/killer 1
C11ORF63 chromosome 11 open reading frame 63
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
C9ORF9 chromosome 9 open reading frame 9
CCDC176 coiled-coil domain containing 176
CD37 CD37 molecule
CD70 CD70 molecule
CEP170B centrosomal protein 170B
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLIP2 CAP-GLY domain containing linker protein 2
CRMP1 collapsin response mediator protein 1
CTAGE9 CTAGE family, member 9
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGAT1 diacylglycerol O-acyltransferase 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNM3 dynamin 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM102A family with sequence similarity 102, member A
FKBP9 FK506 binding protein 9, 63 kDa
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH3 G patch domain containing 3
GPX2 glutathione peroxidase 2
GSTM2 glutathione S-transferase mu 2 (muscle)
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HOXA1 homeobox A1
HRAS Harvey rat sarcoma viral oncogene homolog
IDI2-AS1 IDI2 antisense RNA 1
IL12RB1 interleukin 12 receptor, beta 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIAA0355 KIAA0355
KLF3 Kruppel-like factor 3 (basic)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
MAP6D1 MAP6 domain containing 1
MED9 mediator complex subunit 9
MKL2 MKL/myocardin-like 2
MOCOS molybdenum cofactor sulfurase
MRAS muscle RAS oncogene homolog
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NOD2 nucleotide-binding oligomerization domain containing 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDZD7 PDZ domain containing 7
PGBD5 piggyBac transposable element derived 5
PGP phosphoglycolate phosphatase
PNOC prepronociceptin
POLL polymerase (DNA directed), lambda
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRF1 perforin 1 (pore forming protein)
PSKH1 protein serine kinase H1
RAB33A RAB33A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RWDD2A RWD domain containing 2A
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD1A SET domain containing 1A
SGCE sarcoglycan, epsilon
SNX29P2 sorting nexin 29 pseudogene 2
SPAG1 sperm associated antigen 1
SPATA7 spermatogenesis associated 7
SPRYD7 SPRY domain containing 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TEX40 testis expressed 40
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBR3 transforming growth factor, beta receptor III
THBS3 thrombospondin 3
THBS4 thrombospondin 4
TIAM2 T-cell lymphoma invasion and metastasis 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM53 transmembrane protein 53
TNS2 tensin 2
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TSPAN32 tetraspanin 32
TTC26 tetratricopeptide repeat domain 26
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VN1R1 vomeronasal 1 receptor 1
YY2 YY2 transcription factor
ZNF276 zinc finger protein 276
ZNF408 zinc finger protein 408
ZNF623 zinc finger protein 623