pirenzepine-7226 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the pirenzepine-7226 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADTRP androgen-dependent TFPI-regulating protein
AFF1 AF4/FMR2 family, member 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARRB1 arrestin, beta 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CD52 CD52 molecule
CLCA1 chloride channel accessory 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNOT3 CCR4-NOT transcription complex, subunit 3
CPD carboxypeptidase D
CTBP2 C-terminal binding protein 2
DAAM2 dishevelled associated activator of morphogenesis 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOK2 docking protein 2, 56kDa
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFNA3 ephrin-A3
EMCN endomucin
FAM155A family with sequence similarity 155, member A
FAM186A family with sequence similarity 186, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR3 fibroblast growth factor receptor 3
FRMD4B FERM domain containing 4B
GFER growth factor, augmenter of liver regeneration
GJA4 gap junction protein, alpha 4, 37kDa
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAS GNAS complex locus
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GRK5 G protein-coupled receptor kinase 5
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H2AL histone cluster 1, H2al
HLF hepatic leukemia factor
HOXD1 homeobox D1
IFT122 intraflagellar transport 122
ISL1 ISL LIM homeobox 1
KITLG KIT ligand
KRT19P2 keratin 19 pseudogene 2
LMO1 LIM domain only 1 (rhombotin 1)
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP1 low density lipoprotein receptor-related protein 1
MDFI MyoD family inhibitor
NIPAL2 NIPA-like domain containing 2
OXCT2 3-oxoacid CoA transferase 2
PCM1 pericentriolar material 1
PDE4C phosphodiesterase 4C, cAMP-specific
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PQLC2 PQ loop repeat containing 2
RAB3D RAB3D, member RAS oncogene family
RARG retinoic acid receptor, gamma
REPS1 RALBP1 associated Eps domain containing 1
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS14 regulator of G-protein signaling 14
RNASEH2B ribonuclease H2, subunit B
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS14 ribosomal protein S14
RTEL1 regulator of telomere elongation helicase 1
SDC3 syndecan 3
SIGLEC6 sialic acid binding Ig-like lectin 6
SIK2 salt-inducible kinase 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOCS3 suppressor of cytokine signaling 3
SOS2 son of sevenless homolog 2 (Drosophila)
SPDEF SAM pointed domain containing ETS transcription factor
SSPN sarcospan
SYN2 synapsin II
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAT tyrosine aminotransferase
TBC1D17 TBC1 domain family, member 17
TBX6 T-box 6
TESC tescalcin
TGFB2 transforming growth factor, beta 2
TIMELESS timeless circadian clock
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM212 transmembrane protein 212
TMEM259 transmembrane protein 259
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS1 tensin 1
TRA T cell receptor alpha locus
TUBA3C tubulin, alpha 3c
VAC14 Vac14 homolog (S. cerevisiae)
WDR55 WD repeat domain 55
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZKSCAN5 zinc finger with KRAB and SCAN domains 5

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABLIM3 actin binding LIM protein family, member 3
AR androgen receptor
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BBC3 BCL2 binding component 3
BCAS1 breast carcinoma amplified sequence 1
BEX4 brain expressed, X-linked 4
C1ORF159 chromosome 1 open reading frame 159
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
CAMTA2 calmodulin binding transcription activator 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLDN15 claudin 15
CLSPN claspin
CTNNBIP1 catenin, beta interacting protein 1
DUSP8 dual specificity phosphatase 8
ELOVL4 ELOVL fatty acid elongase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL15 F-box and leucine-rich repeat protein 15
FLCN folliculin
FOXC1 forkhead box C1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FUZ fuzzy planar cell polarity protein
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMIP GEM interacting protein
GNL1 guanine nucleotide binding protein-like 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GUSBP3 glucuronidase, beta pseudogene 3
HAUS6 HAUS augmin-like complex, subunit 6
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IREB2 iron-responsive element binding protein 2
KAT2A K(lysine) acetyltransferase 2A
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP5L low density lipoprotein receptor-related protein 5-like
MAN2C1 mannosidase, alpha, class 2C, member 1
MON1B MON1 secretory trafficking family member B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
NABP2 nucleic acid binding protein 2
NDRG1 N-myc downstream regulated 1
NES nestin
NLK nemo-like kinase
NPIPB15 nuclear pore complex interacting protein family, member B15
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OXTR oxytocin receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGB5 protocadherin gamma subfamily B, 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPP1R26 protein phosphatase 1, regulatory subunit 26
PTCD2 pentatricopeptide repeat domain 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB5B RAB5B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP10 RAN binding protein 10
RIBC2 RIB43A domain with coiled-coils 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF2 ring finger protein 2
RPAP2 RNA polymerase II associated protein 2
SAMD9 sterile alpha motif domain containing 9
SAV1 salvador family WW domain containing protein 1
SCAI suppressor of cancer cell invasion
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SHPK sedoheptulokinase
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMTN smoothelin
SPATS2 spermatogenesis associated, serine-rich 2
SPIDR scaffolding protein involved in DNA repair
SPINK4 serine peptidase inhibitor, Kazal type 4
STARD5 StAR-related lipid transfer (START) domain containing 5
SYT17 synaptotagmin XVII
TEP1 telomerase-associated protein 1
TESK2 testis-specific kinase 2
TEX2 testis expressed 2
TMEM160 transmembrane protein 160
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
XKR8 XK, Kell blood group complex subunit-related family, member 8
XYLT2 xylosyltransferase II
ZBTB3 zinc finger and BTB domain containing 3
ZBTB39 zinc finger and BTB domain containing 39
ZBTB48 zinc finger and BTB domain containing 48
ZBTB6 zinc finger and BTB domain containing 6
ZNF573 zinc finger protein 573
ZNF611 zinc finger protein 611
ZNF721 zinc finger protein 721
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2
ZXDC ZXD family zinc finger C