pirenperone-4679 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the pirenperone-4679 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AKAP5 A kinase (PRKA) anchor protein 5
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ART1 ADP-ribosyltransferase 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
C4BPA complement component 4 binding protein, alpha
C9ORF156 chromosome 9 open reading frame 156
CARD10 caspase recruitment domain family, member 10
CCDC28B coiled-coil domain containing 28B
CFHR4 complement factor H-related 4
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL2A1 collagen, type II, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGKA diacylglycerol kinase, alpha 80kDa
DMPK dystrophia myotonica-protein kinase
DPYSL4 dihydropyrimidinase-like 4
E2F4 E2F transcription factor 4, p107/p130-binding
EFNB1 ephrin-B1
ELAC1 elaC ribonuclease Z 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM149B1 family with sequence similarity 149, member B1
FAXDC2 fatty acid hydroxylase domain containing 2
FBRS fibrosin
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GJA4 gap junction protein, alpha 4, 37kDa
GOLGA2 golgin A2
GOSR2 golgi SNAP receptor complex member 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
HAL histidine ammonia-lyase
HEATR6 HEAT repeat containing 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2AB histone cluster 1, H2ab
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL15 interleukin 15
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
ING2 inhibitor of growth family, member 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPK1 inositol-tetrakisphosphate 1-kinase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LGALS9 lectin, galactoside-binding, soluble, 9
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MPZ myelin protein zero
N4BP2L2 NEDD4 binding protein 2-like 2
NFX1 nuclear transcription factor, X-box binding 1
NIN ninein (GSK3B interacting protein)
NOD1 nucleotide-binding oligomerization domain containing 1
NPC1 Niemann-Pick disease, type C1
PAPPA2 pappalysin 2
PCDHB3 protocadherin beta 3
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PITX1 paired-like homeodomain 1
PRDM2 PR domain containing 2, with ZNF domain
PTGIS prostaglandin I2 (prostacyclin) synthase
REEP2 receptor accessory protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS14 ribosomal protein S14
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEZ6L seizure related 6 homolog (mouse)-like
SH3D21 SH3 domain containing 21
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TAOK1 TAO kinase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMPRSS4 transmembrane protease, serine 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNNT3 troponin T type 3 (skeletal, fast)
TRAF4 TNF receptor-associated factor 4
UBA6 ubiquitin-like modifier activating enzyme 6
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VEZT vezatin, adherens junctions transmembrane protein
VGLL3 vestigial-like family member 3
ZFHX2 zinc finger homeobox 2
ZNF215 zinc finger protein 215
ZNF236 zinc finger protein 236
ZNF280B zinc finger protein 280B
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
AFAP1 actin filament associated protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALS2CL ALS2 C-terminal like
AMT aminomethyltransferase
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARL14 ADP-ribosylation factor-like 14
ARL15 ADP-ribosylation factor-like 15
ARMCX2 armadillo repeat containing, X-linked 2
ATF7IP2 activating transcription factor 7 interacting protein 2
BDKRB1 bradykinin receptor B1
C16ORF45 chromosome 16 open reading frame 45
C9ORF40 chromosome 9 open reading frame 40
CA9 carbonic anhydrase IX
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCNO cyclin O
CCP110 centriolar coiled coil protein 110kDa
CDKL3 cyclin-dependent kinase-like 3
CNN1 calponin 1, basic, smooth muscle
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPNE7 copine VII
CXCL3 chemokine (C-X-C motif) ligand 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DDN dendrin
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
ELSPBP1 epididymal sperm binding protein 1
EN1 engrailed homeobox 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM110B family with sequence similarity 110, member B
FANCF Fanconi anemia, complementation group F
FRMD8 FERM domain containing 8
FRMPD1 FERM and PDZ domain containing 1
GEMIN8 gem (nuclear organelle) associated protein 8
GID4 GID complex subunit 4
GLS2 glutaminase 2 (liver, mitochondrial)
GPNMB glycoprotein (transmembrane) nmb
GPR27 G protein-coupled receptor 27
GTF2I general transcription factor IIi
HIST1H2BJ histone cluster 1, H2bj
HIST1H3I histone cluster 1, H3i
HOXA1 homeobox A1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL6 interleukin 6
IL7 interleukin 7
KIFC1 kinesin family member C1
KLF2 Kruppel-like factor 2
KRT20 keratin 20, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINC00472 long intergenic non-protein coding RNA 472
LINC00597 long intergenic non-protein coding RNA 597
LY96 lymphocyte antigen 96
MDFI MyoD family inhibitor
MGP matrix Gla protein
MRPL41 mitochondrial ribosomal protein L41
MTERF4 mitochondrial transcription termination factor 4
MTSS1L metastasis suppressor 1-like
MYOZ3 myozenin 3
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDRG4 NDRG family member 4
NEUROD1 neuronal differentiation 1
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NME5 NME/NM23 family member 5
NTF3 neurotrophin 3
NUP62CL nucleoporin 62kDa C-terminal like
OCA2 oculocutaneous albinism II
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH12 protocadherin 12
PDK4 pyruvate dehydrogenase kinase, isozyme 4
POLL polymerase (DNA directed), lambda
PRSS8 protease, serine, 8
R3HCC1L R3H domain and coiled-coil containing 1-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIBC2 RIB43A domain with coiled-coils 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCN1B sodium channel, voltage gated, type I beta subunit
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
STAG3 stromal antigen 3
TBKBP1 TBK1 binding protein 1
TM6SF1 transmembrane 6 superfamily member 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TUBA4B tubulin, alpha 4b
TUBB2B tubulin, beta 2B class IIb
ZFP30 ZFP30 zinc finger protein
ZNF528 zinc finger protein 528
ZSCAN2 zinc finger and SCAN domain containing 2