pioglitazone-7528 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the pioglitazone-7528 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ADCY1 adenylate cyclase 1 (brain)
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ANGPTL4 angiopoietin-like 4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP3 aquaporin 3 (Gill blood group)
ARHGAP26 Rho GTPase activating protein 26
BATF3 basic leucine zipper transcription factor, ATF-like 3
BHLHE41 basic helix-loop-helix family, member e41
C16ORF59 chromosome 16 open reading frame 59
C7ORF43 chromosome 7 open reading frame 43
CACTIN cactin, spliceosome C complex subunit
CCNA1 cyclin A1
CCPG1 cell cycle progression 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIB2 calcium and integrin binding family member 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
DGCR2 DiGeorge syndrome critical region gene 2
DGCR8 DGCR8 microprocessor complex subunit
DMBT1 deleted in malignant brain tumors 1
DTX4 deltex 4, E3 ubiquitin ligase
DVL3 dishevelled segment polarity protein 3
EIF1 eukaryotic translation initiation factor 1
EIF3M eukaryotic translation initiation factor 3, subunit M
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
EN2 engrailed homeobox 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FA2H fatty acid 2-hydroxylase
FABP4 fatty acid binding protein 4, adipocyte
FH fumarate hydratase
FKBP10 FK506 binding protein 10, 65 kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPALPP1 GPALPP motifs containing 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFI44L interferon-induced protein 44-like
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL15RA interleukin 15 receptor, alpha
IL1B interleukin 1, beta
JAG2 jagged 2
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KDM7A lysine (K)-specific demethylase 7A
KRT6A keratin 6A, type II
LAMA4 laminin, alpha 4
LINC00260 long intergenic non-protein coding RNA 260
LPCAT4 lysophosphatidylcholine acyltransferase 4
LPIN1 lipin 1
LRRN2 leucine rich repeat neuronal 2
LYPD3 LY6/PLAUR domain containing 3
MAL mal, T-cell differentiation protein
MINK1 misshapen-like kinase 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS12 mitochondrial ribosomal protein S12
MTAP methylthioadenosine phosphorylase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NSUN6 NOP2/Sun domain family, member 6
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
ORAI2 ORAI calcium release-activated calcium modulator 2
PCDH1 protocadherin 1
PDLIM4 PDZ and LIM domain 4
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLIN2 perilipin 2
PRKCD protein kinase C, delta
PTGES prostaglandin E synthase
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB11B RAB11B, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RPL35A ribosomal protein L35a
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDC2 syndecan 2
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK10 serine/threonine kinase 10
TBC1D30 TBC1 domain family, member 30
TFF2 trefoil factor 2
THBS3 thrombospondin 3
TMEM47 transmembrane protein 47
TSC22D4 TSC22 domain family, member 4
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WT1 Wilms tumor 1
ZC3H7B zinc finger CCCH-type containing 7B
ZDHHC14 zinc finger, DHHC-type containing 14

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ADGRG6 adhesion G protein-coupled receptor G6
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APOL6 apolipoprotein L, 6
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATAD2B ATPase family, AAA domain containing 2B
BDNF brain-derived neurotrophic factor
BHLHE40 basic helix-loop-helix family, member e40
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C16ORF45 chromosome 16 open reading frame 45
C1ORF106 chromosome 1 open reading frame 106
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC186 coiled-coil domain containing 186
CD82 CD82 molecule
COL5A2 collagen, type V, alpha 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRYGC crystallin, gamma C
CRYL1 crystallin, lambda 1
CRYZ crystallin, zeta (quinone reductase)
CSRNP3 cysteine-serine-rich nuclear protein 3
CTAGE9 CTAGE family, member 9
CTC1 CTS telomere maintenance complex component 1
CTGF connective tissue growth factor
CTSO cathepsin O
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
EAF2 ELL associated factor 2
EIF5A2 eukaryotic translation initiation factor 5A2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EYA4 EYA transcriptional coactivator and phosphatase 4
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FER fer (fps/fes related) tyrosine kinase
FGD6 FYVE, RhoGEF and PH domain containing 6
FURIN furin (paired basic amino acid cleaving enzyme)
FZD8 frizzled class receptor 8
GDAP1 ganglioside induced differentiation associated protein 1
GLT8D2 glycosyltransferase 8 domain containing 2
GPATCH2 G patch domain containing 2
GRPR gastrin-releasing peptide receptor
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
H1F0 H1 histone family, member 0
HCG4 HLA complex group 4 (non-protein coding)
HDAC7 histone deacetylase 7
HERC2P3 hect domain and RLD 2 pseudogene 3
HIST1H2BC histone cluster 1, H2bc
HP1BP3 heterochromatin protein 1, binding protein 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT81 intraflagellar transport 81
IL18 interleukin 18
IL33 interleukin 33
IRF2 interferon regulatory factor 2
KIAA0319L KIAA0319-like
KIAA1462 KIAA1462
LMNB1 lamin B1
LOC730101 uncharacterized LOC730101
LRRC49 leucine rich repeat containing 49
LRRC61 leucine rich repeat containing 61
MCTP1 multiple C2 domains, transmembrane 1
MRAS muscle RAS oncogene homolog
NAP1L2 nucleosome assembly protein 1-like 2
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUP62CL nucleoporin 62kDa C-terminal like
OCLN occludin
ORC1 origin recognition complex, subunit 1
PARD6A par-6 family cell polarity regulator alpha
PLAU plasminogen activator, urokinase
PLCD1 phospholipase C, delta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLK2 polo-like kinase 2
PPARG peroxisome proliferator-activated receptor gamma
RAB23 RAB23, member RAS oncogene family
RCAN3 RCAN family member 3
RNF43 ring finger protein 43
RPS17P5 ribosomal protein S17 pseudogene 5
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SH3BGR SH3 domain binding glutamate-rich protein
SHROOM2 shroom family member 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TPST1 tyrosylprotein sulfotransferase 1
ZFHX2 zinc finger homeobox 2
ZFP69B ZFP69 zinc finger protein B
ZNF227 zinc finger protein 227
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZNF8 zinc finger protein 8