pioglitazone-7088 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pioglitazone-7088 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD6 abhydrolase domain containing 6
ADCY1 adenylate cyclase 1 (brain)
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANAPC5 anaphase promoting complex subunit 5
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARHGAP26 Rho GTPase activating protein 26
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP10A ATPase, class V, type 10A
ATP13A3 ATPase type 13A3
BAG1 BCL2-associated athanogene
C9ORF114 chromosome 9 open reading frame 114
CDH7 cadherin 7, type 2
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DTX4 deltex 4, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
ELOVL6 ELOVL fatty acid elongase 6
EN1 engrailed homeobox 1
EN2 engrailed homeobox 2
EPOR erythropoietin receptor
FA2H fatty acid 2-hydroxylase
FABP4 fatty acid binding protein 4, adipocyte
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HTT huntingtin
IFI44L interferon-induced protein 44-like
IL11 interleukin 11
IL1B interleukin 1, beta
JUN jun proto-oncogene
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
LAMA4 laminin, alpha 4
LPIN1 lipin 1
MAL mal, T-cell differentiation protein
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MBTD1 mbt domain containing 1
METTL1 methyltransferase like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFE2L3 nuclear factor, erythroid 2-like 3
NRSN2 neurensin 2
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PELP1 proline, glutamate and leucine rich protein 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLIN2 perilipin 2
POMT2 protein-O-mannosyltransferase 2
PPARD peroxisome proliferator-activated receptor delta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRKCD protein kinase C, delta
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGES prostaglandin E synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBPMS RNA binding protein with multiple splicing
RGS19 regulator of G-protein signaling 19
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDC2 syndecan 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFN stratifin
SFT2D2 SFT2 domain containing 2
SH2D2A SH2 domain containing 2A
SIK1 salt-inducible kinase 1
SIM2 single-minded family bHLH transcription factor 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLMO2 slowmo homolog 2 (Drosophila)
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMIM8 small integral membrane protein 8
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
STOM stomatin
TCF3 transcription factor 3
THBD thrombomodulin
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRIM29 tripartite motif containing 29
TSPAN12 tetraspanin 12
TUBA3C tubulin, alpha 3c
ZNF426 zinc finger protein 426

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABI3BP ABI family, member 3 (NESH) binding protein
ADGRG6 adhesion G protein-coupled receptor G6
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASAP1-IT1 ASAP1 intronic transcript 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BAX BCL2-associated X protein
BCAS3 breast carcinoma amplified sequence 3
BDNF brain-derived neurotrophic factor
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BOLA1 bolA family member 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C8ORF60 chromosome 8 open reading frame 60
CBS cystathionine-beta-synthase
CCNO cyclin O
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCLRE1A DNA cross-link repair 1A
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EAF2 ELL associated factor 2
EFNA4 ephrin-A4
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXL15 F-box and leucine-rich repeat protein 15
FBXO2 F-box protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GATA3 GATA binding protein 3
GJC1 gap junction protein, gamma 1, 45kDa
GMPPB GDP-mannose pyrophosphorylase B
GOLGA1 golgin A1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRPR gastrin-releasing peptide receptor
H1F0 H1 histone family, member 0
HIRA histone cell cycle regulator
HIST1H2BI histone cluster 1, H2bi
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL33 interleukin 33
IRAK4 interleukin-1 receptor-associated kinase 4
KIF14 kinesin family member 14
KIFC1 kinesin family member C1
KLHL12 kelch-like family member 12
LINC00597 long intergenic non-protein coding RNA 597
LMNB1 lamin B1
MCMBP minichromosome maintenance complex binding protein
MRPL28 mitochondrial ribosomal protein L28
NEU1 sialidase 1 (lysosomal sialidase)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NT5C 5', 3'-nucleotidase, cytosolic
NXPE3 neurexophilin and PC-esterase domain family, member 3
PAIP2B poly(A) binding protein interacting protein 2B
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX26 peroxisomal biogenesis factor 26
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLXNB3 plexin B3
PNRC1 proline-rich nuclear receptor coactivator 1
PPARG peroxisome proliferator-activated receptor gamma
PRR15L proline rich 15-like
PRSS22 protease, serine, 22
PSENEN presenilin enhancer gamma secretase subunit
PTGFR prostaglandin F receptor (FP)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCEL sciellin
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMA4 glucuronidase, beta pseudogene
SPANXC SPANX family, member C
SPIN1 spindlin 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN2 tectonic family member 2
TMEM187 transmembrane protein 187
TMEM209 transmembrane protein 209
TRIM45 tripartite motif containing 45
TSPAN15 tetraspanin 15
TUBA3D tubulin, alpha 3d
YAP1 Yes-associated protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZFP30 ZFP30 zinc finger protein
ZNF248 zinc finger protein 248
ZNF606 zinc finger protein 606
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816