pinacidil-2406 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pinacidil-2406 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM1 acyl-CoA synthetase medium-chain family member 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARHGAP28 Rho GTPase activating protein 28
ATXN2L ataxin 2-like
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BIK BCL2-interacting killer (apoptosis-inducing)
C2 complement component 2
C2ORF27A chromosome 2 open reading frame 27A
C8A complement component 8, alpha polypeptide
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC106 coiled-coil domain containing 106
CCL23 chemokine (C-C motif) ligand 23
CD58 CD58 molecule
CGA glycoprotein hormones, alpha polypeptide
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CORO1B coronin, actin binding protein, 1B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRTC1 CREB regulated transcription coactivator 1
CTNND1 catenin (cadherin-associated protein), delta 1
CYB561 cytochrome b561
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
DAGLA diacylglycerol lipase, alpha
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM107A family with sequence similarity 107, member A
FBXL18 F-box and leucine-rich repeat protein 18
FGFR2 fibroblast growth factor receptor 2
FLJ11292
FN1 fibronectin 1
FTCD formimidoyltransferase cyclodeaminase
GAL3ST4 galactose-3-O-sulfotransferase 4
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR137 G protein-coupled receptor 137
GUK1 guanylate kinase 1
HIST1H3G histone cluster 1, H3g
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
IQCC IQ motif containing C
KANK1 KN motif and ankyrin repeat domains 1
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KYNU kynureninase
LAMB4 laminin, beta 4
LDLR low density lipoprotein receptor
LHX1 LIM homeobox 1
LMF1 lipase maturation factor 1
MAG myelin associated glycoprotein
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBL1P mannose-binding lectin (protein A) 1, pseudogene
METTL7A methyltransferase like 7A
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MTSS1L metastasis suppressor 1-like
MYL10 myosin, light chain 10, regulatory
NCOR2 nuclear receptor corepressor 2
NF2 neurofibromin 2 (merlin)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPPA natriuretic peptide A
NRCAM neuronal cell adhesion molecule
OLIG2 oligodendrocyte lineage transcription factor 2
PAX7 paired box 7
PCDHA5 protocadherin alpha 5
PCGF3 polycomb group ring finger 3
PGAP3 post-GPI attachment to proteins 3
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PORCN porcupine homolog (Drosophila)
PPARD peroxisome proliferator-activated receptor delta
PRICKLE3 prickle homolog 3 (Drosophila)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTCRA pre T-cell antigen receptor alpha
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RBPMS RNA binding protein with multiple splicing
RGS3 regulator of G-protein signaling 3
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHB Src homology 2 domain containing adaptor protein B
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT3 sirtuin 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMPX small muscle protein, X-linked
SPRR1B small proline-rich protein 1B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SULT4A1 sulfotransferase family 4A, member 1
TGFBR1 transforming growth factor, beta receptor 1
TLR8 toll-like receptor 8
TMEM2 transmembrane protein 2
ZFHX3 zinc finger homeobox 3
ZFPL1 zinc finger protein-like 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34

decreased expression

Symbol Name
ADM adrenomedullin
ADTRP androgen-dependent TFPI-regulating protein
AGO4 argonaute RISC catalytic component 4
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P2 annexin A2 pseudogene 2
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
AXIN1 axin 1
BAHD1 bromo adjacent homology domain containing 1
BHLHE41 basic helix-loop-helix family, member e41
C1ORF54 chromosome 1 open reading frame 54
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN15 calpain 15
CD82 CD82 molecule
CDR2L cerebellar degeneration-related protein 2-like
CENPT centromere protein T
CLCN5 chloride channel, voltage-sensitive 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DDN dendrin
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND2D DENN/MADD domain containing 2D
DKK2 dickkopf WNT signaling pathway inhibitor 2
ECSIT ECSIT signalling integrator
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXD3 exonuclease 3'-5' domain containing 3
FAM163A family with sequence similarity 163, member A
FEM1C fem-1 homolog c (C. elegans)
FHOD1 formin homology 2 domain containing 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC5 histone deacetylase 5
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H2BE histone cluster 1, H2be
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
INF2 inverted formin, FH2 and WH2 domain containing
KIF1BP KIF1 binding protein
KLF10 Kruppel-like factor 10
KLHL26 kelch-like family member 26
KRCC1 lysine-rich coiled-coil 1
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAX1 lymphocyte transmembrane adaptor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTBP2 latent transforming growth factor beta binding protein 2
LZTR1 leucine-zipper-like transcription regulator 1
METTL21B methyltransferase like 21B
MKS1 Meckel syndrome, type 1
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NTSR1 neurotensin receptor 1 (high affinity)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI1 peptidyl arginine deiminase, type I
PBX3 pre-B-cell leukemia homeobox 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIAS3 protein inhibitor of activated STAT, 3
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLS1 plastin 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RECQL4 RecQ protein-like 4
RNF122 ring finger protein 122
RPP25 ribonuclease P/MRP 25kDa subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A9 solute carrier family 12, member 9
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC35E3 solute carrier family 35, member E3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNX16 sorting nexin 16
SUOX sulfite oxidase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TET3 tet methylcytosine dioxygenase 3
TLR1 toll-like receptor 1
TMEM134 transmembrane protein 134
TMEM209 transmembrane protein 209
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPK1 thiamin pyrophosphokinase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TTPAL tocopherol (alpha) transfer protein-like
TUBA3C tubulin, alpha 3c
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
YY2 YY2 transcription factor
ZBTB10 zinc finger and BTB domain containing 10
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF276 zinc finger protein 276
ZNF696 zinc finger protein 696