pimethixene-7426 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pimethixene-7426 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADORA1 adenosine A1 receptor
AHCYL2 adenosylhomocysteinase-like 2
AHNAK2 AHNAK nucleoprotein 2
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOM apolipoprotein M
ARTN artemin
ATF3 activating transcription factor 3
ATN1 atrophin 1
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BBC3 BCL2 binding component 3
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BHLHE40 basic helix-loop-helix family, member e40
BMP2K BMP2 inducible kinase
CALCOCO1 calcium binding and coiled-coil domain 1
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBX7 chromobox homolog 7
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHKB choline kinase beta
CLCN2 chloride channel, voltage-sensitive 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDIT4 DNA-damage-inducible transcript 4
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DOCK5 dedicator of cytokinesis 5
DOK4 docking protein 4
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FASTKD2 FAST kinase domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GP6 glycoprotein VI (platelet)
GRB10 growth factor receptor-bound protein 10
GRIK5 glutamate receptor, ionotropic, kainate 5
GRTP1 growth hormone regulated TBC protein 1
HIST1H2AJ histone cluster 1, H2aj
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMOX1 heme oxygenase 1
HRK harakiri, BCL2 interacting protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFT140 intraflagellar transport 140
IL15RA interleukin 15 receptor, alpha
INSIG1 insulin induced gene 1
IQSEC2 IQ motif and Sec7 domain 2
IRF1 interferon regulatory factor 1
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KAZN kazrin, periplakin interacting protein
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL26 kelch-like family member 26
LHX2 LIM homeobox 2
LPCAT3 lysophosphatidylcholine acyltransferase 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM9 LYR motif containing 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBP myelin basic protein
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDRG1 N-myc downstream regulated 1
NOP16 NOP16 nucleolar protein
NOX1 NADPH oxidase 1
NPTX1 neuronal pentraxin I
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PACS1 phosphofurin acidic cluster sorting protein 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODNL1 podocan-like 1
PODXL2 podocalyxin-like 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R37 protein phosphatase 1, regulatory subunit 37
PRDX2 peroxiredoxin 2
RAD52 RAD52 homolog (S. cerevisiae)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RGS12 regulator of G-protein signaling 12
RPAP2 RNA polymerase II associated protein 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
ST20 suppressor of tumorigenicity 20
TBC1D30 TBC1 domain family, member 30
TBXA2R thromboxane A2 receptor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE4 transducin-like enhancer of split 4
TMEM63A transmembrane protein 63A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TTC23 tetratricopeptide repeat domain 23
UBOX5 U-box domain containing 5
USB1 U6 snRNA biogenesis 1
USP34 ubiquitin specific peptidase 34
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABHD14A abhydrolase domain containing 14A
ACAD8 acyl-CoA dehydrogenase family, member 8
ADRA2C adrenoceptor alpha 2C
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
APOD apolipoprotein D
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BBS1 Bardet-Biedl syndrome 1
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
CAMKMT calmodulin-lysine N-methyltransferase
CCNT1 cyclin T1
CENPT centromere protein T
CGREF1 cell growth regulator with EF-hand domain 1
COQ6 coenzyme Q6 monooxygenase
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CPTP ceramide-1-phosphate transfer protein
CRABP1 cellular retinoic acid binding protein 1
DCAF17 DDB1 and CUL4 associated factor 17
DNM1 dynamin 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM131A family with sequence similarity 131, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
GAB2 GRB2-associated binding protein 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRB7 growth factor receptor-bound protein 7
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIST1H4D histone cluster 1, H4d
IGFBP6 insulin-like growth factor binding protein 6
IL17RA interleukin 17 receptor A
IRAK4 interleukin-1 receptor-associated kinase 4
KAT2B K(lysine) acetyltransferase 2B
KAT7 K(lysine) acetyltransferase 7
KIAA0125 KIAA0125
KLF11 Kruppel-like factor 11
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LYPLA2P1 lysophospholipase II pseudogene 1
MCOLN1 mucolipin 1
METTL8 methyltransferase like 8
MGC12488
MUM1 melanoma associated antigen (mutated) 1
MYO1E myosin IE
NRSN2 neurensin 2
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OCLN occludin
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PBLD phenazine biosynthesis-like protein domain containing
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMM1 phosphomannomutase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPL periplakin
PRMT7 protein arginine methyltransferase 7
PRR15L proline rich 15-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTCD1 pentatricopeptide repeat domain 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBL1 retinoblastoma-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF2 ring finger protein 2
RPAP1 RNA polymerase II associated protein 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SCUBE2 signal peptide, CUB domain, EGF-like 2
SECISBP2 SECIS binding protein 2
SFXN1 sideroflexin 1
SH2D4A SH2 domain containing 4A
SHPK sedoheptulokinase
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC41A3 solute carrier family 41, member 3
SPIDR scaffolding protein involved in DNA repair
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM209 transmembrane protein 209
TMEM57 transmembrane protein 57
TPCN1 two pore segment channel 1
TRIM25 tripartite motif containing 25
TUBA3D tubulin, alpha 3d
TUBGCP5 tubulin, gamma complex associated protein 5
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF106 zinc finger protein 106
ZNF516 zinc finger protein 516
ZW10 zw10 kinetochore protein