pilocarpine-2438 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the pilocarpine-2438 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACAN aggrecan
ADAM20 ADAM metallopeptidase domain 20
ADCY9 adenylate cyclase 9
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANGPTL2 angiopoietin-like 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARNT aryl hydrocarbon receptor nuclear translocator
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BTG2 BTG family, member 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCDC106 coiled-coil domain containing 106
CD200 CD200 molecule
CDV3 CDV3 homolog (mouse)
CEND1 cell cycle exit and neuronal differentiation 1
CFAP69 cilia and flagella associated protein 69
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL6 chemokine (C-X-C motif) ligand 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNAAF1 dynein, axonemal, assembly factor 1
DNAI2 dynein, axonemal, intermediate chain 2
DPF3 D4, zinc and double PHD fingers, family 3
EED embryonic ectoderm development
EFR3B EFR3 homolog B (S. cerevisiae)
EIF5A2 eukaryotic translation initiation factor 5A2
EML2 echinoderm microtubule associated protein like 2
EXOSC2 exosome component 2
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FADS3 fatty acid desaturase 3
FCMR Fc fragment of IgM receptor
FHL1 four and a half LIM domains 1
FOXC1 forkhead box C1
GAS8 growth arrest-specific 8
GID4 GID complex subunit 4
GPM6B glycoprotein M6B
GPR132 G protein-coupled receptor 132
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HFE hemochromatosis
HIST1H3G histone cluster 1, H3g
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
KCTD20 potassium channel tetramerization domain containing 20
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC730101 uncharacterized LOC730101
MAML3 mastermind-like 3 (Drosophila)
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MTSS1 metastasis suppressor 1
MVD mevalonate (diphospho) decarboxylase
NEK9 NIMA-related kinase 9
NF2 neurofibromin 2 (merlin)
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDLIM1 PDZ and LIM domain 1
PDLIM3 PDZ and LIM domain 3
PDPN podoplanin
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PQLC2 PQ loop repeat containing 2
PSG9 pregnancy specific beta-1-glycoprotein 9
PTPRA protein tyrosine phosphatase, receptor type, A
RAB6B RAB6B, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
SCAND2P SCAN domain containing 2 pseudogene
SCN5A sodium channel, voltage gated, type V alpha subunit
SENP7 SUMO1/sentrin specific peptidase 7
SIGLEC9 sialic acid binding Ig-like lectin 9
SIL1 SIL1 nucleotide exchange factor
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SMR3A submaxillary gland androgen regulated protein 3A
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D16 TBC1 domain family, member 16
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
THSD7A thrombospondin, type I, domain containing 7A
TSPAN4 tetraspanin 4
UNC45A unc-45 homolog A (C. elegans)
USP46 ubiquitin specific peptidase 46
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WNT8B wingless-type MMTV integration site family, member 8B
YY1 YY1 transcription factor
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
AES amino-terminal enhancer of split
AHCTF1 AT hook containing transcription factor 1
AMH anti-Mullerian hormone
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAHD1 bromo adjacent homology domain containing 1
BPI bactericidal/permeability-increasing protein
BSPRY B-box and SPRY domain containing
C17ORF53 chromosome 17 open reading frame 53
C22ORF29 chromosome 22 open reading frame 29
CCDC69 coiled-coil domain containing 69
CCDC71 coiled-coil domain containing 71
CD79A CD79a molecule, immunoglobulin-associated alpha
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCN2 chloride channel, voltage-sensitive 2
CLEC4E C-type lectin domain family 4, member E
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COL9A2 collagen, type IX, alpha 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRELD1 cysteine-rich with EGF-like domains 1
CRY2 cryptochrome circadian clock 2
CTSO cathepsin O
CTSV cathepsin V
CXORF56 chromosome X open reading frame 56
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNM3 dynamin 3
DUSP8 dual specificity phosphatase 8
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
EXOSC1 exosome component 1
F13A1 coagulation factor XIII, A1 polypeptide
FANCE Fanconi anemia, complementation group E
FGL1 fibrinogen-like 1
FKBPL FK506 binding protein like
GJA8 gap junction protein, alpha 8, 50kDa
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPATCH3 G patch domain containing 3
GPX2 glutathione peroxidase 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFI6 interferon, alpha-inducible protein 6
INO80D INO80 complex subunit D
ISG15 ISG15 ubiquitin-like modifier
KLHL21 kelch-like family member 21
KLHL28 kelch-like family member 28
LIME1 Lck interacting transmembrane adaptor 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC20 leucine rich repeat containing 20
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGOHB mago-nashi homolog B (Drosophila)
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MEFV Mediterranean fever
MIR22HG MIR22 host gene
MRAS muscle RAS oncogene homolog
MREG melanoregulin
MXD3 MAX dimerization protein 3
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NUBP2 nucleotide binding protein 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDZD7 PDZ domain containing 7
PEX26 peroxisomal biogenesis factor 26
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGP phosphoglycolate phosphatase
PHF1 PHD finger protein 1
PITX2 paired-like homeodomain 2
PNOC prepronociceptin
POLL polymerase (DNA directed), lambda
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
QTRT1 queuine tRNA-ribosyltransferase 1
REC8 REC8 meiotic recombination protein
RHOB ras homolog family member B
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SNAI1 snail family zinc finger 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAT5A signal transducer and activator of transcription 5A
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTN1 tectonic family member 1
TESK1 testis-specific kinase 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM209 transmembrane protein 209
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TTLL1 tubulin tyrosine ligase-like family member 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USB1 U6 snRNA biogenesis 1
YY2 YY2 transcription factor
ZBTB25 zinc finger and BTB domain containing 25
ZDHHC14 zinc finger, DHHC-type containing 14
ZMAT5 zinc finger, matrin-type 5
ZNF219 zinc finger protein 219
ZNF345 zinc finger protein 345
ZNF35 zinc finger protein 35
ZNF493 zinc finger protein 493
ZNF552 zinc finger protein 552
ZNF580 zinc finger protein 580