picrotoxinin-2161 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the picrotoxinin-2161 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALOXE3 arachidonate lipoxygenase 3
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP9B ATPase, class II, type 9B
ATXN7L1 ataxin 7-like 1
B9D2 B9 protein domain 2
BAIAP2 BAI1-associated protein 2
C19ORF66 chromosome 19 open reading frame 66
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASZ1 castor zinc finger 1
CD86 CD86 molecule
CEP170B centrosomal protein 170B
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CREM cAMP responsive element modulator
CTSF cathepsin F
CXCR3 chemokine (C-X-C motif) receptor 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DDAH2 dimethylarginine dimethylaminohydrolase 2
EFNA4 ephrin-A4
EPS8L1 EPS8-like 1
FAM155A family with sequence similarity 155, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
GFER growth factor, augmenter of liver regeneration
GLE1 GLE1 RNA export mediator
GRM1 glutamate receptor, metabotropic 1
GSTTP1 glutathione S-transferase theta pseudogene 1
GYG2 glycogenin 2
HAMP hepcidin antimicrobial peptide
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HIST1H2BI histone cluster 1, H2bi
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IRF6 interferon regulatory factor 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLK2 kallikrein-related peptidase 2
LAMP1 lysosomal-associated membrane protein 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIN7B lin-7 homolog B (C. elegans)
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAP4 microtubule-associated protein 4
MAU2 MAU2 sister chromatid cohesion factor
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP19 matrix metallopeptidase 19
MSRB2 methionine sulfoxide reductase B2
MST1L macrophage stimulating 1-like
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NDNF neuron-derived neurotrophic factor
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PADI2 peptidyl arginine deiminase, type II
PADI4 peptidyl arginine deiminase, type IV
PCLO piccolo presynaptic cytomatrix protein
PHC1 polyhomeotic homolog 1 (Drosophila)
PYGB phosphorylase, glycogen; brain
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RHOT2 ras homolog family member T2
RPS11 ribosomal protein S11
RUNDC3B RUN domain containing 3B
RUNX3 runt-related transcription factor 3
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SAMD14 sterile alpha motif domain containing 14
SF3A2 splicing factor 3a, subunit 2, 66kDa
SIN3B SIN3 transcription regulator family member B
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMTN smoothelin
SPTAN1 spectrin, alpha, non-erythrocytic 1
STARD5 StAR-related lipid transfer (START) domain containing 5
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNDIG1 synapse differentiation inducing 1
TCP10 t-complex 10
THSD7A thrombospondin, type I, domain containing 7A
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TRAF1 TNF receptor-associated factor 1
TRD T cell receptor delta locus
TRIM10 tripartite motif containing 10
TRIM3 tripartite motif containing 3
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VPS9D1 VPS9 domain containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZBTB7A zinc finger and BTB domain containing 7A
ZC3H7B zinc finger CCCH-type containing 7B
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF384 zinc finger protein 384
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BLMH bleomycin hydrolase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF56 chromosome 1 open reading frame 56
CCNJ cyclin J
CENPE centromere protein E, 312kDa
CEP97 centrosomal protein 97kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXORF56 chromosome X open reading frame 56
CYBRD1 cytochrome b reductase 1
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DEAF1 DEAF1 transcription factor
DENND1A DENN/MADD domain containing 1A
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
ELP5 elongator acetyltransferase complex subunit 5
EML4 echinoderm microtubule associated protein like 4
EXOC5 exocyst complex component 5
FAR2 fatty acyl CoA reductase 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF2I general transcription factor IIi
ICK intestinal cell (MAK-like) kinase
IREB2 iron-responsive element binding protein 2
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD15 potassium channel tetramerization domain containing 15
KCTD20 potassium channel tetramerization domain containing 20
LMAN1 lectin, mannose-binding, 1
LMNB1 lamin B1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
METTL16 methyltransferase like 16
MOSPD3 motile sperm domain containing 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NHEJ1 nonhomologous end-joining factor 1
NMD3 NMD3 ribosome export adaptor
NPIPB15 nuclear pore complex interacting protein family, member B15
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PARPBP PARP1 binding protein
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEX26 peroxisomal biogenesis factor 26
PGM3 phosphoglucomutase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLS1 plastin 1
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRMT1 protein arginine methyltransferase 1
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
QTRT1 queuine tRNA-ribosyltransferase 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB23 RAB23, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RARS arginyl-tRNA synthetase
RNF122 ring finger protein 122
RNF146 ring finger protein 146
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPE ribulose-5-phosphate-3-epimerase
RPGR retinitis pigmentosa GTPase regulator
RPP14 ribonuclease P/MRP 14kDa subunit
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SH3YL1 SH3 and SYLF domain containing 1
SHPK sedoheptulokinase
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A40 solute carrier family 25, member 40
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SNIP1 Smad nuclear interacting protein 1
SRD5A3 steroid 5 alpha-reductase 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STX5 syntaxin 5
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCTN1 tectonic family member 1
TEC tec protein tyrosine kinase
TMEM185B transmembrane protein 185B
TRIM16 tripartite motif containing 16
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
XPO7 exportin 7
ZBTB48 zinc finger and BTB domain containing 48
ZBTB6 zinc finger and BTB domain containing 6
ZMAT3 zinc finger, matrin-type 3
ZNF197 zinc finger protein 197
ZNF215 zinc finger protein 215
ZNF250 zinc finger protein 250
ZNF37BP zinc finger protein 37B, pseudogene
ZNF665 zinc finger protein 665
ZNF675 zinc finger protein 675
ZW10 zw10 kinetochore protein