picotamide-7140 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the picotamide-7140 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ABI2 abl-interactor 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMC8 armadillo repeat containing 8
ATP11A ATPase, class VI, type 11A
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BRCA2 breast cancer 2, early onset
BTN3A3 butyrophilin, subfamily 3, member A3
C15ORF39 chromosome 15 open reading frame 39
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C7ORF43 chromosome 7 open reading frame 43
CA5B carbonic anhydrase VB, mitochondrial
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CENPJ centromere protein J
CENPT centromere protein T
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL5A1 collagen, type V, alpha 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTNND2 catenin (cadherin-associated protein), delta 2
CTSF cathepsin F
CXCL5 chemokine (C-X-C motif) ligand 5
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DLK2 delta-like 2 homolog (Drosophila)
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGF18 fibroblast growth factor 18
FKBP15 FK506 binding protein 15, 133kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GPC3 glypican 3
GRIP2 glutamate receptor interacting protein 2
GSDMB gasdermin B
GSK3A glycogen synthase kinase 3 alpha
HIST1H2BJ histone cluster 1, H2bj
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
IGHMBP2 immunoglobulin mu binding protein 2
KLF4 Kruppel-like factor 4 (gut)
KRT19P2 keratin 19 pseudogene 2
KRT34 keratin 34, type I
LAMA4 laminin, alpha 4
LAMP1 lysosomal-associated membrane protein 1
LMO7 LIM domain 7
LRRK1 leucine-rich repeat kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MECP2 methyl CpG binding protein 2
MED25 mediator complex subunit 25
MOCS3 molybdenum cofactor synthesis 3
MPPE1 metallophosphoesterase 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCAPH2 non-SMC condensin II complex, subunit H2
NDE1 nudE neurodevelopment protein 1
NRTN neurturin
ODF2 outer dense fiber of sperm tails 2
OSBPL3 oxysterol binding protein-like 3
PAIP2B poly(A) binding protein interacting protein 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PDLIM5 PDZ and LIM domain 5
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POM121 POM121 transmembrane nucleoporin
PRICKLE3 prickle homolog 3 (Drosophila)
PTMS parathymosin
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RNASEH2B ribonuclease H2, subunit B
RNF6 ring finger protein (C3H2C3 type) 6
RPL7 ribosomal protein L7
RUNX3 runt-related transcription factor 3
SC5D sterol-C5-desaturase
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFTPC surfactant protein C
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SOCS3 suppressor of cytokine signaling 3
TBXAS1 thromboxane A synthase 1 (platelet)
TGFB1 transforming growth factor, beta 1
THOC5 THO complex 5
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TSSK2 testis-specific serine kinase 2
TTC12 tetratricopeptide repeat domain 12
UROD uroporphyrinogen decarboxylase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZC3H3 zinc finger CCCH-type containing 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF286A zinc finger protein 286A
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACTL6A actin-like 6A
ANAPC2 anaphase promoting complex subunit 2
ANOS1 anosmin 1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID4A AT rich interactive domain 4A (RBP1-like)
BIRC3 baculoviral IAP repeat containing 3
BRPF1 bromodomain and PHD finger containing, 1
C21ORF91 chromosome 21 open reading frame 91
CALCOCO1 calcium binding and coiled-coil domain 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CEP131 centrosomal protein 131kDa
CFD complement factor D (adipsin)
CRY1 cryptochrome circadian clock 1
DCAF4 DDB1 and CUL4 associated factor 4
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
ECM1 extracellular matrix protein 1
ENAH enabled homolog (Drosophila)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERCC2 excision repair cross-complementation group 2
FCHSD2 FCH and double SH3 domains 2
FHOD1 formin homology 2 domain containing 1
GAB2 GRB2-associated binding protein 2
GID4 GID complex subunit 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
IPO8 importin 8
ISL1 ISL LIM homeobox 1
JADE1 jade family PHD finger 1
KIRREL kin of IRRE like (Drosophila)
KRT6A keratin 6A, type II
LOC730101 uncharacterized LOC730101
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MITF microphthalmia-associated transcription factor
MPI mannose phosphate isomerase
MXD3 MAX dimerization protein 3
NCS1 neuronal calcium sensor 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
P3H2 prolyl 3-hydroxylase 2
PARP16 poly (ADP-ribose) polymerase family, member 16
PCBP4 poly(rC) binding protein 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PISD phosphatidylserine decarboxylase
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
POLH polymerase (DNA directed), eta
PPL periplakin
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRMT7 protein arginine methyltransferase 7
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIX1 SIX homeobox 1
SKA1 spindle and kinetochore associated complex subunit 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUSD6 sushi domain containing 6
SYF2 SYF2 pre-mRNA-splicing factor
TGFB3 transforming growth factor, beta 3
THBS3 thrombospondin 3
THOC6 THO complex 6
TMCC2 transmembrane and coiled-coil domain family 2
TMEM2 transmembrane protein 2
TMOD3 tropomodulin 3 (ubiquitous)
TPK1 thiamin pyrophosphokinase 1
UBL4A ubiquitin-like 4A
UEVLD UEV and lactate/malate dehyrogenase domains
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR19 WD repeat domain 19
XK X-linked Kx blood group
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZFP36 ZFP36 ring finger protein
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF226 zinc finger protein 226
ZNF254 zinc finger protein 254
ZNF33B zinc finger protein 33B
ZNF552 zinc finger protein 552
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816
ZNF84 zinc finger protein 84
ZW10 zw10 kinetochore protein