phosphatidylinositol 3-kinase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. (Gene Ontology, GO_0005942)
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129 proteins co-occuring with the phosphatidylinositol 3-kinase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.97698
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.95934
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.93832
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.89523
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.69522
BECN1 beclin 1, autophagy related 1.63539
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.52371
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.34338
UVRAG UV radiation resistance associated 1.24393
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.2387
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.23036
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.0812
PTEN phosphatase and tensin homolog 1.0812
INO80D INO80 complex subunit D 1.07461
ATG14 autophagy related 14 1.06144
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 0.920918
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.815322
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.798811
TNS1 tensin 1 0.749094
KIAA0226 KIAA0226 0.739614
AMBRA1 autophagy/beclin-1 regulator 1 0.721688
ATG5 autophagy related 5 0.669858
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.650439
VMP1 vacuole membrane protein 1 0.638005
NRBF2 nuclear receptor binding factor 2 0.603174
GRB2 growth factor receptor-bound protein 2 0.594753
IRS1 insulin receptor substrate 1 0.589295
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.58134
IRS2 insulin receptor substrate 2 0.557629
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 0.552251
PLEK pleckstrin 0.550186
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.537416
CSF1R colony stimulating factor 1 receptor 0.529618
ATG12 autophagy related 12 0.51694
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.498636
DAB2IP DAB2 interacting protein 0.495395
ATG9A autophagy related 9A 0.490135
INS insulin 0.463997
ATG7 autophagy related 7 0.460401
FYN FYN proto-oncogene, Src family tyrosine kinase 0.455214
EGFR epidermal growth factor receptor 0.448054
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 0.446862
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.444482
GAB2 GRB2-associated binding protein 2 0.440916
INPP5J inositol polyphosphate-5-phosphatase J 0.430647
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.415728
ZFYVE26 zinc finger, FYVE domain containing 26 0.401693
RRAGB Ras-related GTP binding B 0.398199
CCNF cyclin F 0.398199
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.39626
CSF1 colony stimulating factor 1 (macrophage) 0.386208
PI3 peptidase inhibitor 3, skin-derived 0.382739
ZFPM2 zinc finger protein, FOG family member 2 0.374666
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.359371
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.358228
TLR4 toll-like receptor 4 0.341907
MYD88 myeloid differentiation primary response 88 0.337373
RAB21 RAB21, member RAS oncogene family 0.314465
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.30254
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.294748
RILP Rab interacting lysosomal protein 0.292897
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.291787
ATG4C autophagy related 4C, cysteine peptidase 0.284769
RNF2 ring finger protein 2 0.282189
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.280349
ZFYVE1 zinc finger, FYVE domain containing 1 0.272633
RNPS1 RNA binding protein S1, serine-rich domain 0.267871
SYK spleen tyrosine kinase 0.251476
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.24894
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.248578
IMMT inner membrane protein, mitochondrial 0.238119
RHEB Ras homolog enriched in brain 0.236683
VAV1 vav 1 guanine nucleotide exchange factor 0.236324
SGK1 serum/glucocorticoid regulated kinase 1 0.234891
ULK1 unc-51 like autophagy activating kinase 1 0.234891
CSH2 chorionic somatomammotropin hormone 2 0.231672
KHSRP KH-type splicing regulatory protein 0.230601
VAV3 vav 3 guanine nucleotide exchange factor 0.225267
IL24 interleukin 24 0.221025
MAP1S microtubule-associated protein 1S 0.219265
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 0.218563
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.216111
LRPPRC leucine-rich pentatricopeptide repeat containing 0.202684
RAG2 recombination activating gene 2 0.198991
DAPK1 death-associated protein kinase 1 0.196999
RB1CC1 RB1-inducible coiled-coil 1 0.19601
GRB7 growth factor receptor-bound protein 7 0.193719
CD19 CD19 molecule 0.1921
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.18859
BANF1 barrier to autointegration factor 1 0.186087
BTK Bruton agammaglobulinemia tyrosine kinase 0.184853
ERBB3 erb-b2 receptor tyrosine kinase 3 0.181227
INSR insulin receptor 0.180045
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.171937
SNAI2 snail family zinc finger 2 0.170888
INPPL1 inositol polyphosphate phosphatase-like 1 0.16935
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.164542
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.158315
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.157943
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.157218
SNORA29 small nucleolar RNA, H/ACA box 29 0.134678
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.127906
CCL11 chemokine (C-C motif) ligand 11 0.126978
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.117246
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.116809
DAP death-associated protein 0.115691
MAP4 microtubule-associated protein 4 0.112959
A1BG alpha-1-B glycoprotein 0.112437
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.111702
VAV2 vav 2 guanine nucleotide exchange factor 0.111442
NF1 neurofibromin 1 0.11112
TLR6 toll-like receptor 6 0.11031
PLD1 phospholipase D1, phosphatidylcholine-specific 0.110125
CYBB cytochrome b-245, beta polypeptide 0.109344
EPHB2 EPH receptor B2 0.109024
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.108042
IL13 interleukin 13 0.106283
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.10607
PNPLA2 patatin-like phospholipase domain containing 2 0.105454
C5AR1 complement component 5a receptor 1 0.105049
CAPNS1 calpain, small subunit 1 0.105012
MAP2 microtubule-associated protein 2 0.104376
TBK1 TANK-binding kinase 1 0.103958
MAPT microtubule-associated protein tau 0.103183
TAT tyrosine aminotransferase 0.10235
TLR1 toll-like receptor 1 0.10104
SELE selectin E 0.100874
MAPK14 mitogen-activated protein kinase 14 0.100538
CCND2 cyclin D2 0.099512