phosphatidylinositol 3-kinase complex, class ia Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. (Gene Ontology, GO_0005943)
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47 proteins co-occuring with the phosphatidylinositol 3-kinase complex, class ia cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.21415
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.18447
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.16101
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.86831
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.45421
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.25232
PTEN phosphatase and tensin homolog 1.04532
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 1.00843
CSF1R colony stimulating factor 1 receptor 0.54771
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.54606
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.544
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.521841
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.520615
CSF1 colony stimulating factor 1 (macrophage) 0.477233
INS insulin 0.476831
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.4608
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.452427
RILP Rab interacting lysosomal protein 0.450438
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.403248
CSH2 chorionic somatomammotropin hormone 2 0.384665
IRS2 insulin receptor substrate 2 0.371599
RAG2 recombination activating gene 2 0.348725
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.333979
BTK Bruton agammaglobulinemia tyrosine kinase 0.332095
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.315212
SNAI2 snail family zinc finger 2 0.314091
INPPL1 inositol polyphosphate phosphatase-like 1 0.311478
TNS1 tensin 1 0.298826
A1BG alpha-1-B glycoprotein 0.278877
GAB2 GRB2-associated binding protein 2 0.278141
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.269335
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.267139
VAV2 vav 2 guanine nucleotide exchange factor 0.266042
NF1 neurofibromin 1 0.262025
TLR6 toll-like receptor 6 0.252202
SYK spleen tyrosine kinase 0.239557
EGFR epidermal growth factor receptor 0.233817
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.226686
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.197993
CAPNS1 calpain, small subunit 1 0.196999
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.194045
PLEK pleckstrin 0.182122
TAT tyrosine aminotransferase 0.175745
TLR1 toll-like receptor 1 0.167366
MAPK14 mitogen-activated protein kinase 14 0.164542
IRS1 insulin receptor substrate 1 0.161068
CCND2 cyclin D2 0.159462