phentolamine-3971 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the phentolamine-3971 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADAM22 ADAM metallopeptidase domain 22
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ART1 ADP-ribosyltransferase 1
ATXN3 ataxin 3
C10ORF10 chromosome 10 open reading frame 10
C1ORF54 chromosome 1 open reading frame 54
C7ORF69 chromosome 7 open reading frame 69
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CARD10 caspase recruitment domain family, member 10
CCL5 chemokine (C-C motif) ligand 5
CD58 CD58 molecule
CD6 CD6 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD86 CD86 molecule
CD96 CD96 molecule
CDK19 cyclin-dependent kinase 19
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CPN2 carboxypeptidase N, polypeptide 2
CPQ carboxypeptidase Q
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYSLTR2 cysteinyl leukotriene receptor 2
DAAM2 dishevelled associated activator of morphogenesis 2
DFNB31 deafness, autosomal recessive 31
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
ERCC2 excision repair cross-complementation group 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM13C family with sequence similarity 13, member C
FAM65B family with sequence similarity 65, member B
FBLN1 fibulin 1
FLNC filamin C, gamma
FXYD7 FXYD domain containing ion transport regulator 7
GAP43 growth associated protein 43
GH1 growth hormone 1
GJD2 gap junction protein, delta 2, 36kDa
GLRA1 glycine receptor, alpha 1
HOXD3 homeobox D3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ITGB6 integrin, beta 6
IZUMO4 IZUMO family member 4
KLF1 Kruppel-like factor 1 (erythroid)
KLHL22 kelch-like family member 22
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRIT1 KRIT1, ankyrin repeat containing
KRT14 keratin 14, type I
LAMA4 laminin, alpha 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOXL2 lysyl oxidase-like 2
LUZP4 leucine zipper protein 4
MAGEC1 melanoma antigen family C1
MTL5 metallothionein-like 5, testis-specific (tesmin)
MYCNOS MYCN opposite strand
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NYNRIN NYN domain and retroviral integrase containing
PARVB parvin, beta
PAX1 paired box 1
PER1 period circadian clock 1
PLAT plasminogen activator, tissue
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXDC1 plexin domain containing 1
PQLC2 PQ loop repeat containing 2
PRB1 proline-rich protein BstNI subfamily 1
PRDX2 peroxiredoxin 2
RANBP3 RAN binding protein 3
REEP2 receptor accessory protein 2
RFPL1 ret finger protein-like 1
RFPL2 ret finger protein-like 2
RHAG Rh-associated glycoprotein
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCN10A sodium channel, voltage gated, type X alpha subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SIM2 single-minded family bHLH transcription factor 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SOX18 SRY (sex determining region Y)-box 18
SPN sialophorin
SPRR2B small proline-rich protein 2B
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STOML1 stomatin (EPB72)-like 1
STS steroid sulfatase (microsomal), isozyme S
SYT11 synaptotagmin XI
TAS2R4 taste receptor, type 2, member 4
TCF4 transcription factor 4
TDRD12 tudor domain containing 12
VPREB3 pre-B lymphocyte 3
ZNF154 zinc finger protein 154
ZNF440 zinc finger protein 440
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
AMPD1 adenosine monophosphate deaminase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
B9D2 B9 protein domain 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L2 BCL2-like 2
BMP10 bone morphogenetic protein 10
BRAF B-Raf proto-oncogene, serine/threonine kinase
C11ORF63 chromosome 11 open reading frame 63
C14ORF79 chromosome 14 open reading frame 79
C1ORF159 chromosome 1 open reading frame 159
C1QB complement component 1, q subcomponent, B chain
C8ORF44 chromosome 8 open reading frame 44
CCNK cyclin K
CES3 carboxylesterase 3
CFHR4 complement factor H-related 4
CHML choroideremia-like (Rab escort protein 2)
CLDN11 claudin 11
CLEC4E C-type lectin domain family 4, member E
COPZ2 coatomer protein complex, subunit zeta 2
CUZD1 CUB and zona pellucida-like domains 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DOCK4 dedicator of cytokinesis 4
DPY19L1P1 DPY19L1 pseudogene 1
DUSP9 dual specificity phosphatase 9
EGLN3 egl-9 family hypoxia-inducible factor 3
ELSPBP1 epididymal sperm binding protein 1
ETV6 ets variant 6
FAM110B family with sequence similarity 110, member B
FAM131A family with sequence similarity 131, member A
FAM155A family with sequence similarity 155, member A
FAM76A family with sequence similarity 76, member A
FBXL8 F-box and leucine-rich repeat protein 8
FFAR2 free fatty acid receptor 2
GAST gastrin
GATA4 GATA binding protein 4
HDAC11 histone deacetylase 11
HIRA histone cell cycle regulator
HIST1H4A histone cluster 1, H4a
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HMOX1 heme oxygenase 1
HOXC8 homeobox C8
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0125 KIAA0125
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT83 keratin 83, type II
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MFSD6 major facilitator superfamily domain containing 6
MMP3 matrix metallopeptidase 3
MRPL41 mitochondrial ribosomal protein L41
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDE1 nudE neurodevelopment protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPTX1 neuronal pentraxin I
PADI3 peptidyl arginine deiminase, type III
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PODNL1 podocan-like 1
POMT2 protein-O-mannosyltransferase 2
PRKCE protein kinase C, epsilon
QSER1 glutamine and serine rich 1
RIBC2 RIB43A domain with coiled-coils 2
RIN1 Ras and Rab interactor 1
SENP7 SUMO1/sentrin specific peptidase 7
SLC16A4 solute carrier family 16, member 4
SLC41A3 solute carrier family 41, member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLPI secretory leukocyte peptidase inhibitor
SPRR1B small proline-rich protein 1B
SRD5A3 steroid 5 alpha-reductase 3
SYNC syncoilin, intermediate filament protein
TBC1D19 TBC1 domain family, member 19
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM21 tripartite motif containing 21
TRIM36 tripartite motif containing 36
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSC22D4 TSC22 domain family, member 4
VN1R1 vomeronasal 1 receptor 1
XYLT2 xylosyltransferase II
ZBTB33 zinc finger and BTB domain containing 33
ZBTB44 zinc finger and BTB domain containing 44
ZFHX2 zinc finger homeobox 2
ZNF230 zinc finger protein 230
ZNF286A zinc finger protein 286A
ZNF34 zinc finger protein 34
ZNF446 zinc finger protein 446
ZNF484 zinc finger protein 484
ZNF506 zinc finger protein 506
ZNF862 zinc finger protein 862