phentolamine-2323 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the phentolamine-2323 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAM23 ADAM metallopeptidase domain 23
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AIRE autoimmune regulator
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALOX12B arachidonate 12-lipoxygenase, 12R type
ANAPC13 anaphase promoting complex subunit 13
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APC adenomatous polyposis coli
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASB1 ankyrin repeat and SOCS box containing 1
CA9 carbonic anhydrase IX
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC88A coiled-coil domain containing 88A
CCR8 chemokine (C-C motif) receptor 8
CD58 CD58 molecule
CLCA1 chloride channel accessory 1
CLTA clathrin, light chain A
CNN1 calponin 1, basic, smooth muscle
CTRB2 chymotrypsinogen B2
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR4 chemokine (C-X-C motif) receptor 4
DGAT1 diacylglycerol O-acyltransferase 1
DGCR8 DGCR8 microprocessor complex subunit
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNALI1 dynein, axonemal, light intermediate chain 1
DST dystonin
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELN elastin
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
FGFR1 fibroblast growth factor receptor 1
FH fumarate hydratase
FHL1 four and a half LIM domains 1
GP5 glycoprotein V (platelet)
GRM8 glutamate receptor, metabotropic 8
HFE hemochromatosis
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HNF1B HNF1 homeobox B
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL1A interleukin 1, alpha
IRF4 interferon regulatory factor 4
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIF25 kinesin family member 25
KREMEN2 kringle containing transmembrane protein 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOXL3 lysyl oxidase-like 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK8 mitogen-activated protein kinase 8
MCTP1 multiple C2 domains, transmembrane 1
MOGAT2 monoacylglycerol O-acyltransferase 2
MRC2 mannose receptor, C type 2
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEU3 sialidase 3 (membrane sialidase)
NEURL1 neuralized E3 ubiquitin protein ligase 1
NNAT neuronatin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUMA1 nuclear mitotic apparatus protein 1
NUP54 nucleoporin 54kDa
PARVB parvin, beta
PCDHGA8 protocadherin gamma subfamily A, 8
POMT2 protein-O-mannosyltransferase 2
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PTCRA pre T-cell antigen receptor alpha
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11B RAB11B, member RAS oncogene family
RNF126P1 ring finger protein 126 pseudogene 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SCNN1B sodium channel, non voltage gated 1 beta subunit
SELL selectin L
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SMG7-AS1 SMG7 antisense RNA 1
SNCAIP synuclein, alpha interacting protein
SPRED2 sprouty-related, EVH1 domain containing 2
SRCAP Snf2-related CREBBP activator protein
SSX3 synovial sarcoma, X breakpoint 3
TBL2 transducin (beta)-like 2
TGM2 transglutaminase 2
THBS4 thrombospondin 4
TNS1 tensin 1
TPSG1 tryptase gamma 1
TRIB2 tribbles pseudokinase 2
TRIM29 tripartite motif containing 29
TRIM38 tripartite motif containing 38
TSC22D4 TSC22 domain family, member 4
TTC38 tetratricopeptide repeat domain 38
VIPR1 vasoactive intestinal peptide receptor 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WNT5A wingless-type MMTV integration site family, member 5A
ZC3H7B zinc finger CCCH-type containing 7B
ZNF177 zinc finger protein 177
ZNF197 zinc finger protein 197
ZNF646 zinc finger protein 646
ZNF750 zinc finger protein 750
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACBD4 acyl-CoA binding domain containing 4
AMPD1 adenosine monophosphate deaminase 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARRB2 arrestin, beta 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP10 bone morphogenetic protein 10
C11ORF63 chromosome 11 open reading frame 63
C14ORF93 chromosome 14 open reading frame 93
C1ORF105 chromosome 1 open reading frame 105
C1ORF56 chromosome 1 open reading frame 56
C3 complement component 3
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDKL3 cyclin-dependent kinase-like 3
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CLDND1 claudin domain containing 1
CLSPN claspin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRLF1 cytokine receptor-like factor 1
CST6 cystatin E/M
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DOCK4 dedicator of cytokinesis 4
DPY19L1P1 DPY19L1 pseudogene 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELOVL4 ELOVL fatty acid elongase 4
ETAA1 Ewing tumor-associated antigen 1
FBXO2 F-box protein 2
FRK fyn-related Src family tyrosine kinase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR157 G protein-coupled receptor 157
GPR21 G protein-coupled receptor 21
GSTM5 glutathione S-transferase mu 5
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IL4R interleukin 4 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0319L KIAA0319-like
LNPEP leucyl/cystinyl aminopeptidase
MAL mal, T-cell differentiation protein
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED15 mediator complex subunit 15
MFSD11 major facilitator superfamily domain containing 11
MUC3A mucin 3A, cell surface associated
NDE1 nudE neurodevelopment protein 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NSD1 nuclear receptor binding SET domain protein 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
PADI1 peptidyl arginine deiminase, type I
PARP16 poly (ADP-ribose) polymerase family, member 16
PER3 period circadian clock 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RFTN1 raftlin, lipid raft linker 1
RLN1 relaxin 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SAV1 salvador family WW domain containing protein 1
SCAI suppressor of cancer cell invasion
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SKI SKI proto-oncogene
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD8 StAR-related lipid transfer (START) domain containing 8
TBKBP1 TBK1 binding protein 1
TLR2 toll-like receptor 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM25 tripartite motif containing 25
TSPYL2 TSPY-like 2
ULBP2 UL16 binding protein 2
VPS9D1 VPS9 domain containing 1
WDR91 WD repeat domain 91
WLS wntless Wnt ligand secretion mediator
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34
ZNF365 zinc finger protein 365
ZNF573 zinc finger protein 573
ZNF816 zinc finger protein 816