phenoxybenzamine-4652 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the phenoxybenzamine-4652 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ADM adrenomedullin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C2CD2L C2CD2-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
COPE coatomer protein complex, subunit epsilon
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOC2B double C2-like domains, beta
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM46A family with sequence similarity 46, member A
FGF18 fibroblast growth factor 18
FICD FIC domain containing
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GRIK3 glutamate receptor, ionotropic, kainate 3
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2AL histone cluster 1, H2al
HMOX1 heme oxygenase 1
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL2 interleukin 2
IL7R interleukin 7 receptor
JMJD6 jumonji domain containing 6
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL24 kelch-like family member 24
LOC1720 dihydrofolate reductase pseudogene
LYRM9 LYR motif containing 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MMP11 matrix metallopeptidase 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRAS muscle RAS oncogene homolog
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP88 nucleoporin 88kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
OSR2 odd-skipped related transciption factor 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PGF placental growth factor
PLA2G3 phospholipase A2, group III
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM2 PR domain containing 2, with ZNF domain
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RAI2 retinoic acid induced 2
RFPL2 ret finger protein-like 2
RFPL3 ret finger protein-like 3
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RPL31 ribosomal protein L31
RUNDC3A RUN domain containing 3A
SAP18 Sin3A-associated protein, 18kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SLA Src-like-adaptor
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX30 SRY (sex determining region Y)-box 30
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIB3 tribbles pseudokinase 3
TSPYL2 TSPY-like 2
XBP1 X-box binding protein 1
ZBTB43 zinc finger and BTB domain containing 43
ZNF165 zinc finger protein 165
ZNF419 zinc finger protein 419

decreased expression

Symbol Name
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGAP32 Rho GTPase activating protein 32
ARL14 ADP-ribosylation factor-like 14
ATAD2B ATPase family, AAA domain containing 2B
B3GNT1
BCL7A B-cell CLL/lymphoma 7A
BNC2 basonuclin 2
CDCA4 cell division cycle associated 4
CEP112 centrosomal protein 112kDa
CHST10 carbohydrate sulfotransferase 10
CLCN5 chloride channel, voltage-sensitive 5
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTSF cathepsin F
DENND1B DENN/MADD domain containing 1B
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
E2F8 E2F transcription factor 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM120C family with sequence similarity 120C
FZD4 frizzled class receptor 4
FZD8 frizzled class receptor 8
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLI3 GLI family zinc finger 3
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPHN gephyrin
GPR87 G protein-coupled receptor 87
GRAMD1B GRAM domain containing 1B
GRHL2 grainyhead-like 2 (Drosophila)
GRPR gastrin-releasing peptide receptor
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HJURP Holliday junction recognition protein
HOXA10 homeobox A10
HOXB13 homeobox B13
HOXC8 homeobox C8
HPS6 Hermansky-Pudlak syndrome 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGSF3 immunoglobulin superfamily, member 3
INHBB inhibin, beta B
KIAA0922 KIAA0922
KIF15 kinesin family member 15
KIFC1 kinesin family member C1
KLF7 Kruppel-like factor 7 (ubiquitous)
LMNB1 lamin B1
LOC100272216 uncharacterized LOC100272216
MKL2 MKL/myocardin-like 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MSL1 male-specific lethal 1 homolog (Drosophila)
MTCL1 microtubule crosslinking factor 1
MUC3B mucin 3B, cell surface associated
MXD3 MAX dimerization protein 3
MYO1E myosin IE
NDP Norrie disease (pseudoglioma)
NOL12 nucleolar protein 12
NR3C2 nuclear receptor subfamily 3, group C, member 2
NSD1 nuclear receptor binding SET domain protein 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PALMD palmdelphin
PBX3 pre-B-cell leukemia homeobox 3
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PID1 phosphotyrosine interaction domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPARG peroxisome proliferator-activated receptor gamma
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRSS8 protease, serine, 8
PSD3 pleckstrin and Sec7 domain containing 3
PSRC1 proline/serine-rich coiled-coil 1
RBM12 RNA binding motif protein 12
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SETD8 SET domain containing (lysine methyltransferase) 8
SGMS1 sphingomyelin synthase 1
SHROOM2 shroom family member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLITRK5 SLIT and NTRK-like family, member 5
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SYNPO synaptopodin
SYTL2 synaptotagmin-like 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TASP1 taspase, threonine aspartase, 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNRC6B trinucleotide repeat containing 6B
TOR4A torsin family 4, member A
TSKU tsukushi, small leucine rich proteoglycan
VANGL1 VANGL planar cell polarity protein 1
WDR7 WD repeat domain 7
WDR76 WD repeat domain 76
ZNF365 zinc finger protein 365