pheniramine-4130 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pheniramine-4130 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAM29 ADAM metallopeptidase domain 29
ADGRL1 adhesion G protein-coupled receptor L1
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AHNAK2 AHNAK nucleoprotein 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANGPTL2 angiopoietin-like 2
ANXA2P3 annexin A2 pseudogene 3
APOM apolipoprotein M
ATF6B activating transcription factor 6 beta
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAIAP3 BAI1-associated protein 3
BIRC3 baculoviral IAP repeat containing 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CELP carboxyl ester lipase pseudogene
CFAP70 cilia and flagella associated protein 70
CHN2 chimerin 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN4 chloride channel, voltage-sensitive 4
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL7A1 collagen, type VII, alpha 1
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DAPK1 death-associated protein kinase 1
DAPK3 death-associated protein kinase 3
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DIAPH2-AS1 DIAPH2 antisense RNA 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ELAC2 elaC ribonuclease Z 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GIMAP6 GTPase, IMAP family member 6
H2AFX H2A histone family, member X
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HEMK1 HemK methyltransferase family member 1
HIST1H2BM histone cluster 1, H2bm
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IDS iduronate 2-sulfatase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL17RC interleukin 17 receptor C
IL1RAP interleukin 1 receptor accessory protein
INHBA inhibin, beta A
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
LEPR leptin receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAL mal, T-cell differentiation protein
MED16 mediator complex subunit 16
MSI1 musashi RNA-binding protein 1
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MX1 MX dynamin-like GTPase 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NF2 neurofibromin 2 (merlin)
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
OMG oligodendrocyte myelin glycoprotein
OXCT2 3-oxoacid CoA transferase 2
PLAC4 placenta-specific 4
PLLP plasmolipin
PRPH2 peripherin 2 (retinal degeneration, slow)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASA3 RAS p21 protein activator 3
RASIP1 Ras interacting protein 1
REC8 REC8 meiotic recombination protein
RGS10 regulator of G-protein signaling 10
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETBP1 SET binding protein 1
SHARPIN SHANK-associated RH domain interactor
SLC35E2 solute carrier family 35, member E2
SLC6A16 solute carrier family 6, member 16
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
STS steroid sulfatase (microsomal), isozyme S
SYNJ2 synaptojanin 2
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D2 TBC1 domain family, member 2
TBC1D22A TBC1 domain family, member 22A
TCF3 transcription factor 3
TDRD12 tudor domain containing 12
TEK TEK tyrosine kinase, endothelial
TIMP3 TIMP metallopeptidase inhibitor 3
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSPAN9 tetraspanin 9
TUBA4B tubulin, alpha 4b
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WNT10B wingless-type MMTV integration site family, member 10B
ZFP64 ZFP64 zinc finger protein
ZNF682 zinc finger protein 682
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMH anti-Mullerian hormone
AMPH amphiphysin
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARPIN actin-related protein 2/3 complex inhibitor
ATAT1 alpha tubulin acetyltransferase 1
BAHCC1 BAH domain and coiled-coil containing 1
BAHD1 bromo adjacent homology domain containing 1
C19ORF40 chromosome 19 open reading frame 40
C7ORF69 chromosome 7 open reading frame 69
C8ORF44 chromosome 8 open reading frame 44
CCDC71 coiled-coil domain containing 71
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CD83 CD83 molecule
CEL carboxyl ester lipase
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLIP4 CAP-GLY domain containing linker protein family, member 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPED1 cadherin-like and PC-esterase domain containing 1
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DEFA4 defensin, alpha 4, corticostatin
DGAT1 diacylglycerol O-acyltransferase 1
DSCAM Down syndrome cell adhesion molecule
DUSP9 dual specificity phosphatase 9
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FAM120C family with sequence similarity 120C
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GLB1L galactosidase, beta 1-like
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HOXC5 homeobox C5
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPB6 heat shock protein, alpha-crystallin-related, B6
IBSP integrin-binding sialoprotein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL2RG interleukin 2 receptor, gamma
IQSEC2 IQ motif and Sec7 domain 2
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCTD7 potassium channel tetramerization domain containing 7
LEFTY1 left-right determination factor 1
LEFTY2 left-right determination factor 2
LGALS4 lectin, galactoside-binding, soluble, 4
LIF leukemia inhibitory factor
LRRC48 leucine rich repeat containing 48
LTC4S leukotriene C4 synthase
MYO15A myosin XVA
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEUROD1 neuronal differentiation 1
NIPAL2 NIPA-like domain containing 2
NLRX1 NLR family member X1
NOTCH4 notch 4
NPFFR1 neuropeptide FF receptor 1
NPY4R neuropeptide Y receptor Y4
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHGB6 protocadherin gamma subfamily B, 6
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAC1 placenta-specific 1
POPDC3 popeye domain containing 3
PPARG peroxisome proliferator-activated receptor gamma
PRKCE protein kinase C, epsilon
PTDSS2 phosphatidylserine synthase 2
RAB30 RAB30, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RCAN3 RCAN family member 3
RHOBTB2 Rho-related BTB domain containing 2
RNF122 ring finger protein 122
RUSC2 RUN and SH3 domain containing 2
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNTA1 syntrophin, alpha 1
STAG3 stromal antigen 3
TBX19 T-box 19
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN2 tectonic family member 2
TEP1 telomerase-associated protein 1
TNS2 tensin 2
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM21 tripartite motif containing 21
UNC119 unc-119 homolog (C. elegans)
USP19 ubiquitin specific peptidase 19
XDH xanthine dehydrogenase
ZNF219 zinc finger protein 219
ZNF230 zinc finger protein 230
ZNF280A zinc finger protein 280A
ZNF304 zinc finger protein 304