phenformin-4283 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the phenformin-4283 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAM8 ADAM metallopeptidase domain 8
AMDHD2 amidohydrolase domain containing 2
AMPD3 adenosine monophosphate deaminase 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARNT aryl hydrocarbon receptor nuclear translocator
BAIAP3 BAI1-associated protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCND2 cyclin D2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTNND2 catenin (cadherin-associated protein), delta 2
CUL7 cullin 7
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK3 death-associated protein kinase 3
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGCR2 DiGeorge syndrome critical region gene 2
DMRT1 doublesex and mab-3 related transcription factor 1
DPF3 D4, zinc and double PHD fingers, family 3
EDA ectodysplasin A
EDN1 endothelin 1
ELOVL2 ELOVL fatty acid elongase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FCAR Fc fragment of IgA receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOSL2 FOS-like antigen 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPNMB glycoprotein (transmembrane) nmb
GPR12 G protein-coupled receptor 12
GPR17 G protein-coupled receptor 17
GRB7 growth factor receptor-bound protein 7
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
IL1RAP interleukin 1 receptor accessory protein
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF4 interferon regulatory factor 4
JUND jun D proto-oncogene
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LIME1 Lck interacting transmembrane adaptor 1
LOXL2 lysyl oxidase-like 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MBTPS2 membrane-bound transcription factor peptidase, site 2
MIP major intrinsic protein of lens fiber
MLXIP MLX interacting protein
MOCS1 molybdenum cofactor synthesis 1
MT1F metallothionein 1F
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PCDHB12 protocadherin beta 12
PIDD1 p53-induced death domain protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKP3 plakophilin 3
PLXND1 plexin D1
PML promyelocytic leukemia
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP1GAP RAP1 GTPase activating protein
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RIBC2 RIB43A domain with coiled-coils 2
RIN1 Ras and Rab interactor 1
RNF208 ring finger protein 208
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RUNDC3A RUN domain containing 3A
RXRB retinoid X receptor, beta
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH2D1A SH2 domain containing 1A
SH3BP2 SH3-domain binding protein 2
SH3D21 SH3 domain containing 21
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMO smoothened, frizzled class receptor
SPN sialophorin
STOML1 stomatin (EPB72)-like 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TET3 tet methylcytosine dioxygenase 3
TMEM180 transmembrane protein 180
TMEM63A transmembrane protein 63A
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
TTLL1 tubulin tyrosine ligase-like family member 1
USP19 ubiquitin specific peptidase 19
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VARS valyl-tRNA synthetase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZFPL1 zinc finger protein-like 1
ZMAT4 zinc finger, matrin-type 4
ZNF44 zinc finger protein 44
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKRD36 ankyrin repeat domain 36
ANKRD36B ankyrin repeat domain 36B
ASAP1-IT1 ASAP1 intronic transcript 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BEX1 brain expressed, X-linked 1
C4ORF29 chromosome 4 open reading frame 29
CCDC106 coiled-coil domain containing 106
CCDC85C coiled-coil domain containing 85C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDH7 cadherin 7, type 2
CEP295 centrosomal protein 295kDa
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
DCAF13 DDB1 and CUL4 associated factor 13
DENND5B DENN/MADD domain containing 5B
DEPDC1 DEP domain containing 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELP6 elongator acetyltransferase complex subunit 6
FAM169A family with sequence similarity 169, member A
FAM204A family with sequence similarity 204, member A
FGF23 fibroblast growth factor 23
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXN2 forkhead box N2
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
H2AFJ H2A histone family, member J
HAUS2 HAUS augmin-like complex, subunit 2
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HOXC8 homeobox C8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
KIAA0319L KIAA0319-like
KIRREL kin of IRRE like (Drosophila)
KLF13 Kruppel-like factor 13
KLHL28 kelch-like family member 28
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LPPR4 lipid phosphate phosphatase-related protein type 4
MBTD1 mbt domain containing 1
MFSD11 major facilitator superfamily domain containing 11
MGC12488
MIS18BP1 MIS18 binding protein 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
PACS1 phosphofurin acidic cluster sorting protein 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PODNL1 podocan-like 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRR14L proline rich 14-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PWAR5 Prader Willi/Angelman region RNA 5
RBBP5 retinoblastoma binding protein 5
RFWD3 ring finger and WD repeat domain 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL13P5 ribosomal protein L13 pseudogene 5
SCAI suppressor of cancer cell invasion
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SP4 Sp4 transcription factor
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAOK1 TAO kinase 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEP1 telomerase-associated protein 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TMEM209 transmembrane protein 209
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUBA3D tubulin, alpha 3d
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBQLN4 ubiquilin 4
UNKL unkempt family zinc finger-like
USB1 U6 snRNA biogenesis 1
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VEZT vezatin, adherens junctions transmembrane protein
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZNF124 zinc finger protein 124
ZNF136 zinc finger protein 136
ZNF160 zinc finger protein 160
ZNF264 zinc finger protein 264
ZNF286A zinc finger protein 286A
ZNF562 zinc finger protein 562
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF667 zinc finger protein 667
ZNF721 zinc finger protein 721