phenformin-3622 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the phenformin-3622 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AATK apoptosis-associated tyrosine kinase
ADRB2 adrenoceptor beta 2, surface
AKAP13 A kinase (PRKA) anchor protein 13
ALX4 ALX homeobox 4
ANGPTL2 angiopoietin-like 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATAT1 alpha tubulin acetyltransferase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
BAX BCL2-associated X protein
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALML3 calmodulin-like 3
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CD82 CD82 molecule
CLCF1 cardiotrophin-like cytokine factor 1
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CORO7 coronin 7
CSF1 colony stimulating factor 1 (macrophage)
CTIF CBP80/20-dependent translation initiation factor
DAPK2 death-associated protein kinase 2
DENND1C DENN/MADD domain containing 1C
DKFZP434C153 DKFZP434C153 protein
DLL3 delta-like 3 (Drosophila)
DRD1 dopamine receptor D1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EMILIN2 elastin microfibril interfacer 2
EPPIN epididymal peptidase inhibitor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV6 ets variant 6
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FLOT1 flotillin 1
FN1 fibronectin 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GGT1 gamma-glutamyltransferase 1
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GYG2 glycogenin 2
HTN1 histatin 1
IFI6 interferon, alpha-inducible protein 6
IGSF6 immunoglobulin superfamily, member 6
IL11RA interleukin 11 receptor, alpha
IL1RN interleukin 1 receptor antagonist
JAK3 Janus kinase 3
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KHK ketohexokinase (fructokinase)
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOC100130331 POTE ankyrin domain family, member F pseudogene
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA6 melanoma antigen family A6
MAGOH2P mago-nashi homolog 2, pseudogene
MARK4 MAP/microtubule affinity-regulating kinase 4
MEF2D myocyte enhancer factor 2D
MKL1 megakaryoblastic leukemia (translocation) 1
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYO9B myosin IXB
NF1 neurofibromin 1
NOL12 nucleolar protein 12
NRF1 nuclear respiratory factor 1
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OXCT2 3-oxoacid CoA transferase 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PIPOX pipecolic acid oxidase
PLXNB1 plexin B1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RASIP1 Ras interacting protein 1
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RSU1 Ras suppressor protein 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLIT1 slit homolog 1 (Drosophila)
SSTR5 somatostatin receptor 5
STS steroid sulfatase (microsomal), isozyme S
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRB thyroid hormone receptor, beta
TMOD1 tropomodulin 1
TTLL7 tubulin tyrosine ligase-like family member 7
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
WIPF1 WAS/WASL interacting protein family, member 1
WNT16 wingless-type MMTV integration site family, member 16
WSCD1 WSC domain containing 1
ZFAND5 zinc finger, AN1-type domain 5
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF304 zinc finger protein 304

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAP2 ArfGAP with dual PH domains 2
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AHSP alpha hemoglobin stabilizing protein
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARPIN actin-related protein 2/3 complex inhibitor
ATG10 autophagy related 10
BEGAIN brain-enriched guanylate kinase-associated
BMP10 bone morphogenetic protein 10
C11ORF80 chromosome 11 open reading frame 80
C17ORF53 chromosome 17 open reading frame 53
C1ORF105 chromosome 1 open reading frame 105
C5AR1 complement component 5a receptor 1
CD53 CD53 molecule
CEND1 cell cycle exit and neuronal differentiation 1
CNPY4 canopy FGF signaling regulator 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPA4 carboxypeptidase A4
CTRL chymotrypsin-like
DAGLA diacylglycerol lipase, alpha
DCAF13 DDB1 and CUL4 associated factor 13
DEPDC5 DEP domain containing 5
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DOK2 docking protein 2, 56kDa
EGFL7 EGF-like-domain, multiple 7
EMP3 epithelial membrane protein 3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPN1 epsin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV7 ets variant 7
FAM212B family with sequence similarity 212, member B
FAM76A family with sequence similarity 76, member A
FAT4 FAT atypical cadherin 4
FBXO31 F-box protein 31
GLDC glycine dehydrogenase (decarboxylating)
GPATCH2L G patch domain containing 2-like
GRB7 growth factor receptor-bound protein 7
HIST1H2BM histone cluster 1, H2bm
HLA-DMB major histocompatibility complex, class II, DM beta
HOXA4 homeobox A4
IBSP integrin-binding sialoprotein
IFNA17 interferon, alpha 17
KCNIP1 Kv channel interacting protein 1
LIF leukemia inhibitory factor
LIME1 Lck interacting transmembrane adaptor 1
LINC01587 long intergenic non-protein coding RNA 1587
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
LRRC14 leucine rich repeat containing 14
MAGEA5 melanoma antigen family A5
MAOB monoamine oxidase B
MBTD1 mbt domain containing 1
MEFV Mediterranean fever
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMRN2 multimerin 2
MRPL41 mitochondrial ribosomal protein L41
MYOZ3 myozenin 3
NDE1 nudE neurodevelopment protein 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPTX2 neuronal pentraxin II
ONECUT1 one cut homeobox 1
ONECUT2 one cut homeobox 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RECQL4 RecQ protein-like 4
RELN reelin
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RNF2 ring finger protein 2
RPL10L ribosomal protein L10-like
SCD5 stearoyl-CoA desaturase 5
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SP1 Sp1 transcription factor
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TEX40 testis expressed 40
TMEM209 transmembrane protein 209
TWF2 twinfilin actin binding protein 2
UPK2 uroplakin 2
VASH2 vasohibin 2
WDR76 WD repeat domain 76
ZNF280A zinc finger protein 280A
ZNF721 zinc finger protein 721
ZSCAN2 zinc finger and SCAN domain containing 2