phenformin-2312 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the phenformin-2312 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACPP acid phosphatase, prostate
ADGRG1 adhesion G protein-coupled receptor G1
AHNAK2 AHNAK nucleoprotein 2
ANGPTL2 angiopoietin-like 2
ANKRD55 ankyrin repeat domain 55
ARC activity-regulated cytoskeleton-associated protein
ATG10 autophagy related 10
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C19ORF66 chromosome 19 open reading frame 66
C1ORF68 chromosome 1 open reading frame 68
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH19 cadherin 19, type 2
CDH8 cadherin 8, type 2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
CNR2 cannabinoid receptor 2 (macrophage)
CRP C-reactive protein, pentraxin-related
CTNS cystinosin, lysosomal cystine transporter
CTSZ cathepsin Z
CXXC4 CXXC finger protein 4
DGAT1 diacylglycerol O-acyltransferase 1
DNASE2B deoxyribonuclease II beta
DOC2B double C2-like domains, beta
EPHB2 EPH receptor B2
FCMR Fc fragment of IgM receptor
FLRT2 fibronectin leucine rich transmembrane protein 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GJA8 gap junction protein, alpha 8, 50kDa
GLRA1 glycine receptor, alpha 1
GLS glutaminase
GPR1 G protein-coupled receptor 1
HIST1H3I histone cluster 1, H3i
HRH2 histamine receptor H2
ICOSLG inducible T-cell co-stimulator ligand
IFI6 interferon, alpha-inducible protein 6
IGHMBP2 immunoglobulin mu binding protein 2
IGL immunoglobulin lambda locus
ITGA7 integrin, alpha 7
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD17 potassium channel tetramerization domain containing 17
KIDINS220 kinase D-interacting substrate, 220kDa
KLHL22 kelch-like family member 22
KRT83 keratin 83, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LECT1 leukocyte cell derived chemotaxin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGOH2P mago-nashi homolog 2, pseudogene
MAP1B microtubule-associated protein 1B
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MIER2 mesoderm induction early response 1, family member 2
MKL1 megakaryoblastic leukemia (translocation) 1
MMP11 matrix metallopeptidase 11
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC3B mucin 3B, cell surface associated
NIPAL3 NIPA-like domain containing 3
NME5 NME/NM23 family member 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PHF1 PHD finger protein 1
PLTP phospholipid transfer protein
POMT2 protein-O-mannosyltransferase 2
PRB4 proline-rich protein BstNI subfamily 4
PTPRO protein tyrosine phosphatase, receptor type, O
PXN paxillin
RAB11B RAB11B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RGS14 regulator of G-protein signaling 14
RRAGB Ras-related GTP binding B
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERHL2 serine hydrolase-like 2
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35G2 solute carrier family 35, member G2
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTB spectrin, beta, erythrocytic
STXBP6 syntaxin binding protein 6 (amisyn)
TCF3 transcription factor 3
TGM2 transglutaminase 2
TIGD6 tigger transposable element derived 6
TPM3 tropomyosin 3
UGT8 UDP glycosyltransferase 8
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VIPR1 vasoactive intestinal peptide receptor 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZNF137P zinc finger protein 137, pseudogene
ZNF175 zinc finger protein 175
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABHD17B abhydrolase domain containing 17B
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACBD4 acyl-CoA binding domain containing 4
AFAP1 actin filament associated protein 1
AGMAT agmatine ureohydrolase (agmatinase)
AHR aryl hydrocarbon receptor
ALS2CL ALS2 C-terminal like
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAHCC1 BAH domain and coiled-coil containing 1
BCORL1 BCL6 corepressor-like 1
BPGM 2,3-bisphosphoglycerate mutase
C4ORF29 chromosome 4 open reading frame 29
CAPN15 calpain 15
CCDC132 coiled-coil domain containing 132
CCNO cyclin O
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPJ centromere protein J
CHML choroideremia-like (Rab escort protein 2)
CRY2 cryptochrome circadian clock 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPY19L1P1 DPY19L1 pseudogene 1
DUSP13 dual specificity phosphatase 13
DVL1 dishevelled segment polarity protein 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPPK1 epiplakin 1
EXD3 exonuclease 3'-5' domain containing 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM131A family with sequence similarity 131, member A
FBXO2 F-box protein 2
FKBP14 FK506 binding protein 14, 22 kDa
FOXI1 forkhead box I1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GSTM5 glutathione S-transferase mu 5
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HIST1H2AJ histone cluster 1, H2aj
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOOK1 hook microtubule-tethering protein 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFT140 intraflagellar transport 140
IL4R interleukin 4 receptor
ITGA10 integrin, alpha 10
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KEL Kell blood group, metallo-endopeptidase
LIG3 ligase III, DNA, ATP-dependent
MBTD1 mbt domain containing 1
MCC mutated in colorectal cancers
MCOLN1 mucolipin 1
MUC3A mucin 3A, cell surface associated
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMU neuromedin U
OLFML3 olfactomedin-like 3
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA6 protocadherin alpha 6
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POLL polymerase (DNA directed), lambda
PRAF2 PRA1 domain family, member 2
RARS arginyl-tRNA synthetase
RFTN1 raftlin, lipid raft linker 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF39 ring finger protein 39
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SNAI2 snail family zinc finger 2
SPON2 spondin 2, extracellular matrix protein
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STAG3 stromal antigen 3
STK25 serine/threonine kinase 25
TBC1D17 TBC1 domain family, member 17
TMEM180 transmembrane protein 180
TMEM53 transmembrane protein 53
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM21 tripartite motif containing 21
TSPYL2 TSPY-like 2
TTC17 tetratricopeptide repeat domain 17
UBQLN4 ubiquilin 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
WDR91 WD repeat domain 91
WLS wntless Wnt ligand secretion mediator
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBED1 zinc finger, BED-type containing 1
ZNF10 zinc finger protein 10
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF862 zinc finger protein 862