personality disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. (Human Disease Ontology, DOID_1510)
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Genes

170 genes co-occuring with the disease personality disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ZAN zonadhesin (gene/pseudogene) 2.07259
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.93186
MAOA monoamine oxidase A 1.85729
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.74869
CLPS colipase, pancreatic 1.48648
FLNA filamin A, alpha 1.45485
TPH1 tryptophan hydroxylase 1 1.42279
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.36684
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.3481
TMPRSS9 transmembrane protease, serine 9 1.29833
GOLPH3 golgi phosphoprotein 3 (coat-protein) 1.28654
CGA glycoprotein hormones, alpha polypeptide 1.27781
DRD2 dopamine receptor D2 1.27519
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 1.18066
COMT catechol-O-methyltransferase 1.17464
ANKK1 ankyrin repeat and kinase domain containing 1 1.16307
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 1.14178
DRD4 dopamine receptor D4 1.11898
GAN gigaxonin 1.10636
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.08831
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.06018
OXT oxytocin/neurophysin I prepropeptide 1.00499
TXLNG taxilin gamma 0.941611
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.941196
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.934556
TRH thyrotropin-releasing hormone 0.926692
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.916787
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.897051
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.89623
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.878605
COL25A1 collagen, type XXV, alpha 1 0.847488
NXF5 nuclear RNA export factor 5 0.838885
GRIK3 glutamate receptor, ionotropic, kainate 3 0.805257
ATG4C autophagy related 4C, cysteine peptidase 0.78066
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.770435
NXF1 nuclear RNA export factor 1 0.765535
SPAG5 sperm associated antigen 5 0.761047
PEG10 paternally expressed 10 0.743141
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.741517
AVEN apoptosis, caspase activation inhibitor 0.736243
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.723694
NXF2B nuclear RNA export factor 2B 0.717635
NXF2 nuclear RNA export factor 2 0.717635
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.717635
TENM4 teneurin transmembrane protein 4 0.716425
NPAS4 neuronal PAS domain protein 4 0.709572
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.69751
MRPL49 mitochondrial ribosomal protein L49 0.694301
MAOB monoamine oxidase B 0.688692
NPS neuropeptide S 0.677903
AVPR1A arginine vasopressin receptor 1A 0.656837
NINJ2 ninjurin 2 0.653276
BDNF brain-derived neurotrophic factor 0.646953
POMC proopiomelanocortin 0.63907
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.633563
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.627672
FOXJ2 forkhead box J2 0.624143
NRXN3 neurexin 3 0.619442
SLITRK1 SLIT and NTRK-like family, member 1 0.613965
OXTR oxytocin receptor 0.612011
SULT4A1 sulfotransferase family 4A, member 1 0.603811
FDXR ferredoxin reductase 0.588222
PNP purine nucleoside phosphorylase 0.581996
KNTC1 kinetochore associated 1 0.577716
LBR lamin B receptor 0.577716
DRD3 dopamine receptor D3 0.571495
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.569552
ARHGAP32 Rho GTPase activating protein 32 0.561392
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.557509
AMY1C amylase, alpha 1C (salivary) 0.529994
AMY1A amylase, alpha 1A (salivary) 0.529994
AMY1B amylase, alpha 1B (salivary) 0.529994
SNAP25 synaptosomal-associated protein, 25kDa 0.524974
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.521888
CRH corticotropin releasing hormone 0.517649
TPH2 tryptophan hydroxylase 2 0.51188
CORT cortistatin 0.495793
SHB Src homology 2 domain containing adaptor protein B 0.469197
PSAT1 phosphoserine aminotransferase 1 0.455224
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.45447
ZNF804A zinc finger protein 804A 0.452962
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.446558
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.443171
DRD5 dopamine receptor D5 0.442418
STOM stomatin 0.437154
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.433772
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.420266
SLC45A2 solute carrier family 45, member 2 0.401199
ARHGAP1 Rho GTPase activating protein 1 0.386679
PRL prolactin 0.385565
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.371847
NPEPPS aminopeptidase puromycin sensitive 0.369997
CLOCK clock circadian regulator 0.362239
ADAR adenosine deaminase, RNA-specific 0.358551
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.356709
HOXD13 homeobox D13 0.354868
MRI1 methylthioribose-1-phosphate isomerase 1 0.354499
AGPS alkylglycerone phosphate synthase 0.353763
SRPX2 sushi-repeat containing protein, X-linked 2 0.353763
BCO1 beta-carotene oxygenase 1 0.347879
LPP LIM domain containing preferred translocation partner in lipoma 0.338341
BMP2K BMP2 inducible kinase 0.337242
APP amyloid beta (A4) precursor protein 0.331025
CHRM2 cholinergic receptor, muscarinic 2 0.327375
FGD1 FYVE, RhoGEF and PH domain containing 1 0.317182
FKBP5 FK506 binding protein 5 0.312827
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.312102
IPP intracisternal A particle-promoted polypeptide 0.307395
MCF2 MCF.2 cell line derived transforming sequence 0.300173
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.294413
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.285802
GLS2 glutaminase 2 (liver, mitochondrial) 0.284728
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.283655
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.282225
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.280439
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.279367
ADCY2 adenylate cyclase 2 (brain) 0.258417
CHD7 chromodomain helicase DNA binding protein 7 0.255241
TXNL4B thioredoxin-like 4B 0.253831
RXFP3 relaxin/insulin-like family peptide receptor 3 0.242595
OPRM1 opioid receptor, mu 1 0.237009
CRLF1 cytokine receptor-like factor 1 0.235616
CCKAR cholecystokinin A receptor 0.231102
NCR3 natural cytotoxicity triggering receptor 3 0.216332
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.210589
NTSR1 neurotensin receptor 1 (high affinity) 0.206248
ARRB1 arrestin, beta 1 0.203933
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.200982
GAS6 growth arrest-specific 6 0.1936
TPT1 tumor protein, translationally-controlled 1 0.190168
FMR1 fragile X mental retardation 1 0.189551
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.184424
LEP leptin 0.173314
MFGE8 milk fat globule-EGF factor 8 protein 0.166319
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.163317
IL6 interleukin 6 0.161139
SCN3A sodium channel, voltage gated, type III alpha subunit 0.158097
HMBS hydroxymethylbilane synthase 0.13347
IDS iduronate 2-sulfatase 0.127117
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.12397
MAEA macrophage erythroblast attacher 0.12349
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.123342
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.123149
CTSB cathepsin B 0.118962
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.112203
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.102335
PRSS3 protease, serine, 3 0.101708
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.099854
MCM8 minichromosome maintenance complex component 8 0.099789
NOG noggin 0.096812
SHBG sex hormone-binding globulin 0.094655
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.094334
MMP12 matrix metallopeptidase 12 0.092136
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.091361
C10ORF2 chromosome 10 open reading frame 2 0.090207
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.089944
F2 coagulation factor II (thrombin) 0.089569
DNAH8 dynein, axonemal, heavy chain 8 0.089569
ILK integrin-linked kinase 0.088581
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.088543
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.088275
KMT2A lysine (K)-specific methyltransferase 2A 0.088199
C6ORF25 chromosome 6 open reading frame 25 0.087391
ATXN3 ataxin 3 0.087314
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.087004
TACR1 tachykinin receptor 1 0.086577
GATA4 GATA binding protein 4 0.084533
PYY peptide YY 0.084493
TNF tumor necrosis factor 0.084414
CA2 carbonic anhydrase II 0.083497