peripheral vascular disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain. (Human Disease Ontology, DOID_341)
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Genes

127 genes associated with the disease peripheral vascular disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FGG fibrinogen gamma chain 2.66306
FGA fibrinogen alpha chain 2.54174
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.41711
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.33658
APOC1 apolipoprotein C-I 2.26733
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.08132
CCND3 cyclin D3 2.05106
FGB fibrinogen beta chain 2.0208
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.0208
PROCR protein C receptor, endothelial 1.93741
PLRG1 pleiotropic regulator 1 1.92766
ITFG3 integrin alpha FG-GAP repeat containing 3 1.909
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.88852
MMP3 matrix metallopeptidase 3 1.86151
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 1.51016
ICAM1 intercellular adhesion molecule 1 1.49392
ODF3B outer dense fiber of sperm tails 3B 1.48894
ZFPM2 zinc finger protein, FOG family member 2 1.48894
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 1.4851
STXBP5 syntaxin binding protein 5 (tomosyn) 1.47477
PHACTR1 phosphatase and actin regulator 1 1.45255
BLK BLK proto-oncogene, Src family tyrosine kinase 1.40325
TFR2 transferrin receptor 2 1.37597
HK1 hexokinase 1 1.35663
SYCE2 synaptonemal complex central element protein 2 1.341
RCL1 RNA terminal phosphate cyclase-like 1 1.33613
PRKCE protein kinase C, epsilon 1.31515
SH2B3 SH2B adaptor protein 3 1.30954
TFRC transferrin receptor 1.29735
PDGFD platelet derived growth factor D 1.27521
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 1.24299
PLG plasminogen 1.2206
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase 1.14929
LPA lipoprotein, Lp(a) 1.14929
OR10Z1 olfactory receptor, family 10, subfamily Z, member 1 1.12703
THRB thyroid hormone receptor, beta 1.1139
HBS1L HBS1-like translational GTPase 1.09588
PSRC1 proline/serine-rich coiled-coil 1 1.06123
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.03105
G6PD glucose-6-phosphate dehydrogenase 1.02486
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.945428
FBXO7 F-box protein 7 0.932337
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.932337
RBM38 RNA binding motif protein 38 0.923046
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.923046
TMPRSS6 transmembrane protease, serine 6 0.894262
C5ORF56 chromosome 5 open reading frame 56 0.894262
DCHS2 dachsous cadherin-related 2 0.872896
CHURC1 churchill domain containing 1 0.872896
MAX MYC associated factor X 0.872896
ITPKC inositol-trisphosphate 3-kinase C 0.872896
CCND2 cyclin D2 0.825265
IL6R interleukin 6 receptor 0.790827
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 0.790827
LDLR low density lipoprotein receptor 0.774217
ACOXL acyl-CoA oxidase-like 0.7623
RASA2 RAS p21 protein activator 2 0.7623
HLA-DOB major histocompatibility complex, class II, DO beta 0.752991
KITLG KIT ligand 0.745324
SYK spleen tyrosine kinase 0.738873
LIPC lipase, hepatic 0.738873
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.738873
RAB37 RAB37, member RAS oncogene family 0.73332
CD300LF CD300 molecule-like family member f 0.73332
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 0.724323
NKX2-3 NK2 homeobox 3 0.724323
CBS cystathionine-beta-synthase 0.682635
HEYL hes-related family bHLH transcription factor with YRPW motif-like 0.682635
NRG4 neuregulin 4 0.682635
MIA melanoma inhibitory activity 0.670996
TRIM58 tripartite motif containing 58 0.661797
PCCB propionyl CoA carboxylase, beta polypeptide 0.65413
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.641775
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.63666
SMOC1 SPARC related modular calcium binding 1 0.63207
HFE hemochromatosis 0.58494
DENND4A DENN/MADD domain containing 4A 0.58494
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.58494
VMP1 vacuole membrane protein 1 0.58494
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.572184
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.561725
OR51V1 olfactory receptor, family 51, subfamily V, member 1 0.561725
MYB v-myb avian myeloblastosis viral oncogene homolog 0.552621
PTPRC protein tyrosine phosphatase, receptor type, C 0.537125
NLRP3 NLR family, pyrin domain containing 3 0.52461
CCDC162P coiled-coil domain containing 162, pseudogene 0.52461
SCARB1 scavenger receptor class B, member 1 0.52461
CETP cholesteryl ester transfer protein, plasma 0.464771
NUP205 nucleoporin 205kDa 0.464771
CENPU centromere protein U 0.464771
ZPR1 ZPR1 zinc finger 0.449873
CD40 CD40 molecule, TNF receptor superfamily member 5 0.438544
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.438544
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene 0.438544
COL4A1 collagen, type IV, alpha 1 0.438544
APOB apolipoprotein B 0.368757
TECRL trans-2,3-enoyl-CoA reductase-like 0.345945
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.345945
ABI2 abl-interactor 2 0.327313
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.327313
MED30 mediator complex subunit 30 0.311576
COL4A2 collagen, type IV, alpha 2 0.264872
BARHL2 BarH-like homeobox 2 0.256228
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.256228
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.256228
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.256228
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.256228
WDFY4 WDFY family member 4 0.197766
PELI1 pellino E3 ubiquitin protein ligase 1 0.197766
ZFHX3 zinc finger homeobox 3 0.197766
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 0.197766
PCSK2 proprotein convertase subtilisin/kexin type 2 0.15771
RNF213 ring finger protein 213 0.15771
CDK14 cyclin-dependent kinase 14 0.126165
C20ORF196 chromosome 20 open reading frame 196 0.126165
LPAR3 lysophosphatidic acid receptor 3 0.126165
GCKR glucokinase (hexokinase 4) regulator 0.100789
DNAH5 dynein, axonemal, heavy chain 5 0.100789
RNF157 ring finger protein 157 0.100789
NUMB numb homolog (Drosophila) 0.080593
BTBD1 BTB (POZ) domain containing 1 0.064973
IGHV2-70 immunoglobulin heavy variable 2-70 0.064973
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.064973
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.064973
MRPS22 mitochondrial ribosomal protein S22 0.052255
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.043246
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.043246